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Philippe Renaud

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Related publications (301)

Synergistic NGF/B27 Gradients Position Synapses Heterogeneously in 3D Micropatterned Neural Cultures

Philippe Renaud, Dominique Zosso, Anja Kunze, Ana Valero

Native functional brain circuits show different numbers of synapses (synaptic densities) in the cerebral cortex. Until now, different synaptic densities could not be studied in vitro using current cell culture methods for primary neurons. Herein, we presen ...

Public Library of Science2011

Low material budget microfabricated cooling devices for particle detectors and front-end electronics

Philippe Renaud, Harald Van Lintel, Alessandro Mapelli

Novel cooling systems with very low material budget are being fabricated and studied. They consist of silicon wafers in which microchannels are etched and closed by bonding another wafer. This cooling option is being considered for future HEP detectors of ...

2011

Simulation of epiretinal prostheses - Evaluation of geometrical factors affecting stimulation thresholds

Philippe Renaud, Grégoire Cosendai, Arnaud Bertsch, Sri Harsha Kasi Raj, Willyan Hasenkamp Carreira

Background An accurate understanding of the electrical interaction between retinal prostheses and retinal tissue is important to design effective devices. Previous studies have used modelling approaches to simulate electric fields generated by epiretinal p ...

BioMed Central2011

Micropatterning neural cell cultures in 3D with a multi-layered scaffold

Philippe Renaud, Anja Kunze, Michele Giugliano, Ana Valero

Cortical neurons, in their native state, are organized in six different cell layers; and the thickness of the cell layer ranges from 0.12 mm to 0.4 mm. The structure of cell layers plays an important role in neurodegenerative diseases or corticogenesis. We ...

2011

Continuous and label-free toxicity screening of human hepatocytes on chip reveals frequency-dependant impedance profiles

Philippe Renaud, Robert Meissner, Bilge Eker

We present an electrical impedance based biosensor on a microfluidic cell culture platform that enables label-free and re- al-time investigation of drug toxicity-induced effects on hepatocytes. The temporal evolution of the impedance at different frequenci ...

2011

Synapse distribution in a 2D-3D micropatterned neural cell culture

Philippe Renaud, Anja Kunze

2011

Miniaturized bacterial biosensor system for arsenic detection holds great promise for making integrated measurement device

Philippe Renaud, Harald Van Lintel, Nina Buffi

Combining bacterial bioreporters with microfluidics systems holds great promise for in-field detection of chemical or toxicity targets. Recently we showed how Escherichia coli cells engineered to produce a variant of green fluorescent protein after contact ...

2011

Link between Alginate Reaction Front Propagation and General Reaction Diffusion Theory

Philippe Renaud, Jürgen Brugger, Thomas Michael Braschler, Kristopher Pataky, Ana Valero, Ludovica Colella

We provide a common theoretical framework reuniting specific models for the Ca2+-alginate system and general reaction diffusion theory along with experimental validation on a microfluidic chip. As a starting point, we use a set of nonlinear, partial differ ...

2011

Implantable neurological probe for identifying location of neurological target e.g. neurons, has stylet provided in internal lumen and configured to contact support cylinder to selectively extend shafts during implantation

Philippe Renaud, André Mercanzini

The probe has support cylinder (214) that is slidingly provided in distal portion of internal lumen. Several shafts coupled to support cylinder and arranged to be selectively extended from distal end of elongated shaft. Several conductive traces provided o ...

2011

Co-pathological states of tau proteins in a 3D micropatterned neural cell culture

Philippe Renaud, Anja Kunze, Robert Meissner, Serena Brando

In vitro studies of Alzheimer’s disease are based on homogenously seeded neural cells. These studies reveal molecular pathway mechanism related to neurite degeneration, but they cannot analyze interactions between diseased and healthy cells. Furthermore, t ...

2011

Distinguishing drug-induced minor morphological changes from major cellular damage via label-free impedimetric toxicity screening

Philippe Renaud, Arnaud Bertsch, Sri Harsha Kasi Raj, Robert Meissner, Bilge Eker

We present a novel perfusion-based microfluidic platform for label-free drug toxicity screening which can single out non-lethal morphological changes from cellular death using electrical impedance spectroscopy. Minor cellular changes such as cell-cell cont ...

2011

Polyimide foam-like microstructures: technology and mechanical properties

Philippe Renaud, Martinus Gijs, Sébastien Jiguet, Pierre Joris, Jagoda Anna Dobrzynska

We report a process for the realization of polyimide films with custom-designed microporosity based on the heat-induced depolymerization of polyimide-embedded polypropylene carbonate microstructures. The foam-like microstructures are up to 40 µm thick and ...

Institute of Physics2011

Development of a microfluidics biosensor for agarose-bead immobilized Escherichia coli bioreporter cells for arsenite detection in aqueous samples

Philippe Renaud, Harald Van Lintel, Nina Buffi

Contamination with arsenic is a recurring problem in both industrialized and developing countries. Drinking water supplies for large populations can have concentrations much higher than the permissible levels (for most European countries and the United Sta ...

2011

Co-Pathological Connected Primary Neurons in a Microfluidic Device for Alzheimer Studies

Philippe Renaud, Anja Kunze, Robert Meissner, Serena Brando

This communication presents a novel experi- mental model for Alzheimer studies, where connected pri- mary neurons were set into subtend, co-pathological states. Cortical neurons were cultured in two separated cell com- partments in a microfluidic device. A ...

Wiley-Blackwell2011

Synthesis of Unusual Oxime Ethers by Reaction of Tetranitromethane with B-Alkylcatecholboranes

Philippe Renaud, Kurt Schenk

The reaction of tetranitromethane with B-alkylcatecholboranes leads to the formation of unusual dinitrooxime ethers. A tentative mechanism is provided, which suggests the involvement of extremely fast addition of alkyl radicals to tetranitromethane. The su ...

2010

A Ca2+ ion selective electrode biosensor in microfluidics to monitor hepatocyte’s activities

Philippe Renaud, Harald Van Lintel, Robert Meissner

Ca2+ plays a crucial role in cell communication. For example, periodical changes in Ca2+ concentration act as cell sig- nals. Intracellular Ca2+ signals have been measured by Ca2+ sensitive fluorescent dye [1]. In this study, extracellular Ca2+ variation w ...

2010

A unified approach to dielectric single cell analysis: Impedance and dielectrophoretic force spectroscopy

Philippe Renaud, Thomas Michael Braschler, Ana Valero

In this review we present a unified approach for single cell dielectric spectroscopy. Impedance spectroscopy and dielectrophoretic cell sorting, current microtechnologies applied in electrical analysis of single cells are discussed based on their closely r ...

Royal Society of Chemistry2010

Stimulating apparatus for stimulating neurological target of live animal has stimulation source in communication with at least one micro-electrode to stimulate neurological target at respective preferred frequency

Philippe Renaud, André Mercanzini

A preferred frequency is identified, being usable to stimulate a neurological target within a mammalian body using at least one microelectrode positioned at or near the target. To establish efficient and effective stimulation, an impedance analyzer is prov ...

2010

Controlled release nanoparticle-embedded coatings reduce the tissue reaction to neuroprostheses

Philippe Renaud, Jeffrey Alan Hubbell, André Mercanzini, Philippe Colin, Jean-Charles Bensadoun, Sai Reddy

Controlled release coatings were developed for neuroprostheses with the aim of combating the tissue reaction following implantation in the brain. The coatings consist of poly(propylene sulfide) drug-eluting nanoparticles embedded in a poly(ethylene oxide) ...

Elsevier2010

Fluidic microstructuring of alginate hydrogels for the single cell niche

Philippe Renaud, Jürgen Brugger, Thomas Michael Braschler, Kristopher Pataky, Ana Valero, Ludovica Colella

Controlling alginate gel formation by diffusion of Ca2+ ions through a filter barrier, a layer-by-layer deposition technique with resolution on the size scale of a single cell is presented. It offers the possibility of exposing cells under biocompatible co ...

Royal Society of Chemistry2010

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