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Philippe Renaud

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Related publications (301)

Very High Throughput Electrical Cell Lysis and Extraction of Intracellular Compounds Using 3D Carbon Electrodes in Lab-on-a-Chip Devices

Philippe Renaud, Freddy Radtke, Rajwinder Lehal, Rodrigo Martinez Duarte

Here we present an electrical lysis throughput of 600 microliters per minute at high cell density (108 yeast cells per ml) with 90% efficiency, thus improving the current common throughput of one microliter per minute. We also demonstrate the extraction of ...

2012

Micro-channel cooling for high-energy physics particle detectors and electronics

Philippe Renaud, Alessandro Mapelli

Micro-channel cooling is gaining considerable attention as an alternative technique for cooling of High-Energy Physics (HEP) detectors and Front-End (FE) electronics. This technology is being evaluated for future tracking devices, where material budget lim ...

IEEE2012

Migration dynamics of breast cancer cells in a tunable 3D interstitial flow chamber

Philippe Renaud, Melody Swartz, Ulrike Haessler, Jeremy Teo

The migration of cells such as leukocytes, tumor cells, and fibroblasts through 3D matrices is critical for regulating homeostasis and immunity and for driving pathogenesis. Interstitial flow through the extracellular matrix, which can substantially increa ...

2012

Facile fabrication of nanofluidic diode membranes using anodic aluminium oxide

Philippe Renaud, Arnaud Bertsch, Jürgen Brugger, Fabien Patrick Wildhaber, Oscar Vazquez Mena, Songmei Wu

Active control of ion transport plays important roles in chemical and biological analytical processes. Nanofluidic systems hold the promise for such control through electrostatic interaction between ions and channel surfaces. Most existing experiments rely ...

Royal Soc Chemistry2012

Multiple-frequency impedance measurements in continuous flow for automated evaluation of yeast cell lysis

Philippe Renaud, Niccolo Piacentini, Willyan Hasenkamp Carreira

This paper reports on an electrical lysis device integrating multiple-frequency impedance measurements for automated evaluation of the lysis efficiency and counting of the lysed cells. Conventional techniques use chemical reagents to dissolve the cell memb ...

Elsevier2012

Microelectrode-based dielectric spectroscopy of glucose effect on erythrocytes

Philippe Renaud, Ludovica Colella

The dielectric response of biconcave erythrocytes exposed to D-glucose and I.-glucose has been investigated using a double array of planar interdigitated microelectrodes on a glass microchip. Erythrocytes are analyzed under physiological conditions suspend ...

2012

Microfluidic synthesis of chitosan-based nanoparticles for fuel cell applications

Philippe Renaud, Arnaud Bertsch, Fatemeh Sadat Majedi, Mohammad Mahdi Hasani-Sadrabadi, Mojtaba Taghipoor

A microfluidic platform is developed for the synthesis of monodisperse, 100 nm, chitosan based nanoparticles using nanogelation with ATP. The resulting nanoparticles tuned and enhanced transport and electrochemical properties of Nafion based nanocomposite ...

Royal Society of Chemistry2012

Portable Technologies for Self-Monitoring of Coagulation Time: A Review

Philippe Renaud, Lynda Metref

Anti-coagulation treatments are required for medical conditions that become more and more frequent with the ageing of the population in developed countries (atrial fibrillation, deep-venous thrombosis, heart prosthetic valves, etc.). These treatments gener ...

2012

Materials for neural interfaces

Philippe Renaud

The treatment of disorders of the nervous system poses a major clinical challenge. Development of neuromodulation (i.e., interfacing electronics to nervous tissue to modulate its function) has provided patients with neuronal-related deficits a new tool to ...

2012

Preparation of 5-Membered Rings via Radical Addition-Translocation-Cyclization (RATC) Processes Mediated by Diethyl Thiophosphites

Philippe Renaud, Kurt Schenk

A practical method for the formation of thiophosphonates bearing functionalized monocyclic, fused bicyclic and spirocyclic residues is presented. The procedure requires the easily available terminal alkynes as starting materials as well as commercially and ...

Wiley2011

Total Synthesis of (+/-)-Cylindricine C

Philippe Renaud, Kurt Schenk

A concise synthesis of (+/-)-cylindricine C and its C(13)-epimer is described. Starting from 1-octyne, cylindricine C and 13-epi-cylindricine C were prepared in 11% and 15% yields, respectively. The synthesis involves the preparation of the central tricycl ...

2011

Concise Synthesis of Pyrrolidine and Indolizidine Alkaloids by a Highly Convergent Three-Component Reaction

Philippe Renaud, Kurt Schenk

The synthesis of pyrrolidine and indolizidine derivatives through radical carboazidation of alkenes with alpha-iodoketones, followed by reductive amination, is described. When properly substituted, further lactamization afforded pyrrolizidinones in good yi ...

2011

A novel approach to dielectrophoresis using carbon electrodes

Philippe Renaud, Rodrigo Martinez Duarte

Carbon-electrode dielectrophoresis (carbon-DEP) is demonstrated here as an alternative to more traditional DEP techniques. Carbon-DEP combines advantages of metal-electrode and insulator-based DEP by using low-cost fabrication techniques and low voltages f ...

Wiley-Blackwell2011

Simulations to study spatial extent of stimulation and effect of electrode–tissue gap in subretinal implants

Philippe Renaud, Arnaud Bertsch, Sri Harsha Kasi Raj

We present a finite element based simulation and analysis method to describe the spatial extent of stimulation and the effects of electrode–tissue interactions in subretinal prostheses. In particular, we estimate the threshold stimulation current needed to ...

Elsevier2011

Implantable neurological probe for performing physiological measurement of patient, has microelectrode element that is arranged along the protrusion extended away from surface of supportive backing layer

Philippe Renaud, André Mercanzini

Described herein are microelectrode array devices, and methods of fabrication and use of the same, to provide highly localized and efficient electrical stimulation of a neurological target. The device includes multiple microelectrode elements arranged alon ...

2011

Tracking and synchronization of the yeast cell cycle using dielectrophoretic opacity

Philippe Renaud, Nicolas Demierre, Thomas Michael Braschler, Ana Valero

Cell cycle synchronization is an important tool for the study of the cell division stages and signalling. It provides homogeneous cell cultures that are of importance to develop and improve processes such as protein synthesis and drug screening. The main a ...

Royal Society of Chemistry2011

Cell viability assessment by flow cytometry using yeast as cell model

Philippe Renaud, Raphaël Tornay, Nina Buffi, Niccolo Piacentini

This paper reports the new combination of cell sorting and counting capabilities on a single device. Most state-of-the-art devices combining these technologies use optical techniques requiring complicated experimental setups and labeled samples. The use of ...

2011

Instrumented Prosthesis for Knee Implants Monitoring

Steve Tanner, Kamiar Aminian, Philippe Renaud, Catherine Dehollain, Arnaud Bertsch, Peter Ryser, Eric Meurville, Hooman Dejnabadi, Pierre-André Farine, Oguz Atasoy, Brigitte Jolles-Haeberli, Arash Arami, Willyan Hasenkamp Carreira, Shafqat Ali, Matteo Simoncini

In this work we present an instrumented smart knee prosthesis for in-vivo measurement of forces and kinematics. Studying the constraints, we designed minimal sensory systems to be placed in the polyethylene part of the prosthesis. The magnetic sensors and ...

IEEE2011

Separation of platelets from other blood cells in continuous-flow by dielectrophoresis field-flow-fractionation

Philippe Renaud, Raphaël Tornay, Niccolo Piacentini

We present a microfluidic device capable of separating platelets from other blood cells in continuous flow using dielectrophoresis field-flow-fractionation. The use of hydrodynamic focusing in combination with the application of a dielectrophoretic force a ...

American Institute of Physics2011

Development and Studies of Novel Microfabricated Radiation Hard Scintillation Detectors With High Spatial Resolution

Philippe Renaud, Alessandro Mapelli, Sébastien Jiguet, Noelia Vico Triviño

A new type of scintillation detector is being developed with standard microfabrication techniques. It consists of a dense array of scintillating waveguides obtained by coupling microfluidic channels filled with a liquid scintillator to photodetectors. Easy ...

Institute of Electrical and Electronics Engineers2011

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