Publication

On-chip impedance-spectroscopy for flow-cytometry using a differential electrode sensor

Philippe Renaud
2001
Conference Papers

Abstract

On-chip cell handling and analysis is given more and more interest, as new cytometry devices can be realised or efficiently combined and integrated. The developed sensor presents several improvements compared to other integrated flow cytometers. It is aimed at diagnostic applications for cell counting and separation in hematology and allows fast cell screening using simultaneous multi-frequency measurements. One major improvement is that the sensor sensitivity to the electrode properties is eliminated by a differential electrode measurement. Negative dielectrophoretic forces can be used to realize a subsequent cell-sorting device.

Official source

https://infoscience.epfl.ch/entities/publication/5d77c82f-744f-41fd-9b63-1c48e5d8b1fb

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Philippe Renaud
2001
Conference Papers

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/5d77c82f-744f-41fd-9b63-1c48e5d8b1fb

About this result

Related concepts (32)

Flow cytometry

Flow cytometry (FC) is a technique used to detect and measure physical and chemical characteristics of a population of cells or particles. In this process, a sample containing cells or particles is suspended in a fluid and injected into the flow cytometer instrument. The sample is focused to ideally flow one cell at a time through a laser beam, where the light scattered is characteristic to the cells and their components. Cells are often labeled with fluorescent markers so light is absorbed and then emitted in a band of wavelengths.

Lab-on-a-chip

A lab-on-a-chip (LOC) is a device that integrates one or several laboratory functions on a single integrated circuit (commonly called a "chip") of only millimeters to a few square centimeters to achieve automation and high-throughput screening. LOCs can handle extremely small fluid volumes down to less than pico-liters. Lab-on-a-chip devices are a subset of microelectromechanical systems (MEMS) devices and sometimes called "micro total analysis systems" (μTAS). LOCs may use microfluidics, the physics, manipulation and study of minute amounts of fluids.

Cytometry

Cytometry is the measurement of number and characteristics of cells. Variables that can be measured by cytometric methods include cell size, cell count, cell morphology (shape and structure), cell cycle phase, DNA content, and the existence or absence of specific proteins on the cell surface or in the cytoplasm. Cytometry is used to characterize and count blood cells in common blood tests such as the complete blood count.

Related publications (1)

On-chip impedance-spectroscopy for flow-cytometry using a differential electrode sensor

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