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Horst Vogel

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Related publications (116)

Micropositioning and microscopic observation of individual picoliter-sized containers within SU-8 microchannels

Horst Vogel, Christoph Schreiter, Jürgen Brugger

We describe the fabrication and application of a bioanalytical chip, made of SU-8 photoresist, comprising integrated, high aspect-ratio microfluidic channels, suitable to manipulate and investigate vesicles, cell fragments and biological cells. A central m ...

2007

A FRET map of membrane anchors suggests distinct microdomains of heterotrimeric G proteins

Horst Vogel

Company of Biologists2007

Analysis of the π+ π- π+ π- and π+ π0 π- π0 final states in quasi-real two-photon collisions at LEP

Eduardo Sanchez, Horst Vogel, Aurelio Bay, Jian Zhao, Liang Sun, Qian Wang, Zhirui Xu, Matthias Weber, Ji Hyun Kim, Werner Lustermann, Xiao Wang, Zheng Wang

The reactions γ γ → π+ π- π+ π- and γ γ → π+ π0 π- π0 are studied with the L3 detector at LEP in a data sample collected at centre-of-mass energies from 161 GeV to 209 GeV with a total integrated luminosity of 698 pb-1. A spin-parity-helicity analysis of t ...

2006

A search for flaring very-high-energy cosmic gamma-ray sources with the L3+C muon spectrometer

Eduardo Sanchez, Horst Vogel, Aurelio Bay, Yu Lei, Jian Zhao, Camille Haller, Liang Sun, Qian Wang, Zhirui Xu, Matthias Weber, Ji Hyun Kim, Werner Lustermann, Xiao Wang, Yifei Guo, Xuan Yang, Zheng Wang

The L3+C muon detector at the CERN electron-positron collider, LEP, is used for the detection of very-high-energy cosmic gamma-ray sources through the observation of muons of energies above 20, 30, 50 and 100 GeV. Daily or monthly excesses in the rate of s ...

Elsevier2006

Search for neutral MSSM Higgs bosons at LEP

André Rouge, Eduardo Sanchez, Horst Vogel, Aurelio Bay, Jian Zhao, Bénédicte Marie Maréchal, Frédéric Teubert, Rémy Teuscher, Liang Sun, Shan Jin, Songmei Wu, Qian Wang, Greig Alan Cowan, Csaba Hajdu, Zhirui Xu, Francesco Cerutti, Mark Tobin, Peter Hansen, Lei Zhang, John Wilson, Paolo Ronchese, Matthias Weber, Ji Hyun Kim, Georgios Anagnostou, Simone Campana, Werner Lustermann, Xiao Wang, Zheng Wang

2006

Visualizing odorant receptor trafficking in living cells down to the single-molecule level

Horst Vogel, Horst Pick, Valérie Jacquier, Jean-Manuel Segura

Despite the importance of trafficking for regulating G protein-coupled receptor signaling, for many members of the seven transmembrane helix protein family, such as odorant receptors, little is known about this process in live cells. Here, the complete lif ...

National Academy of Sciences2006

Cell Membranes Suspended Across Nanoaperture Arrays

Jean-Baptiste Perez, Horst Vogel, Christian Santschi, Jürgen Brugger, Christophe Danelon

The authors present a method for spreading large (> 100 mm2) cell membrane fragments across nanoapertures in planar supports. Electron-beam and focused-ion-beam lithog. were used to fabricate arrays of 50-600 nm diam. holes in free-standing silicon nitride ...

2006

Supported cell-membrane sheets for functional fluorescence imaging of membrane proteins

Jean-Baptiste Perez, Horst Vogel, Jean-Manuel Segura

Cell-membrane sheets suitable for in-vitro functional fluorescence studies have been prepd. by direct detachment from cell membranes using poly-L-lysine-coated glass slides. The resulting transferred planar membranes conserve the compn. as well as most pro ...

2006

Micro- and nanostructured devices for investigating biomolecular interactions

Jean-Baptiste Perez, Horst Vogel, Christian Santschi, Christoph Schreiter, Jürgen Brugger, Christophe Danelon

Cell membrane receptors and ion channels are essential in many different cellular processes. To analyse the activity of membrane proteins in vesicles and biological cells, we fabricated micro- nanostructured chips, enabling the application of electrophysio ...

2006

Determining a receptor-ligand interaction useful in e.g. drug screening involves repetitive application of reversibly binding fluorescent ligands with fast association-dissociation kinetics

Rudolf Hovius, Horst Vogel, Marinela Gjoni Boillat, Jean-Manuel Segura, Christoph Schreiter

NOVELTY - Determining a receptor-ligand interaction involves repeatedly contacting a cell comprising a receptor, with a ligand, of the receptor in which the ligand has a fluorescence labeling group and binds reversibly to the receptor under conditions in w ...

2006

Fabrication and functionalization of nanochannels by electron-beam-induced silicon oxide deposition

Horst Vogel, Christian Santschi, Jürgen Brugger, Christophe Danelon

We report on the fabrication and electrical characterization of functionalized solid-state nanopores in low stress silicon nitride membranes. First, a pore of approximately 50 nm diameter was drilled using a focused ion beam technique, followed by the loca ...

2006

Monitoring the Diffusion of Single Heterotrimeric G Proteins in Supported Cell-membrane Sheets Reveals their Partitioning into Microdomains

Jean-Baptiste Perez, Horst Vogel, Jean-Manuel Segura, Joachim Piguet

Supported cell-membrane sheets are promising in vitro systems to investigate the properties of membranes with native protein/lipid composition, in particular their sub-compartmentalization and the differential localization of proteins associated to them. W ...

Elsevier2006

Multifunctional Lipid/Quantum-Dots Hybrid Nanocontainers for Controlled Targeting of Live Cells

Pierre-Yves Bolinger, Horst Vogel, Jacques Dubochet, Gopakumar Gopalakrishnan, Paulina Izewska, Christophe Danelon, Davide Demurtas

In this communication, we report on an interesting observation of wide-ranging potential for cellular imaging and manipulation: Hydrophobic QDs can be easily incorporated into the bilayer membrane of lipid vesicles. Such lipid/QD nanocontainer hybrid vesic ...

Wiley-VCH Verlag GmbH2006

FRET imaging reveals that functional neurokinin-1 receptors are monomeric and reside in membrane microdomains of live cells

Rudolf Hovius, Horst Vogel, Jean-Manuel Segura, Kai Johnsson, Nathalie George

The lateral organization of a prototypical G protein-coupled receptor, the neurokinin-1 receptor (NK1R), was investigated in living cells by fluorescence resonance energy transfer (FRET) microscopy, taking advantage of the recently developed acyl carrier p ...

National Academy of Sciences2006

Method for testing a substance interacting with a target molecule

Horst Vogel, Hanna Jankevics

The present invention relates to a method for testing a substance interacting with a target molecule in a cell by fluorescence correlation spectroscopy (FCS) by adding a test substance to the cell and determining a distribution of diffusion coefficients fo ...

2006

Posttranslational covalent labeling reveals heterogeneous mobility of individual G protein-coupled receptors in living cells

Horst Vogel, Jean-Manuel Segura, Kai Johnsson, Bruno Meyer, Raphael Franzini, Nathalie George

2006

Functional asymmetry of transmembrane segments in nicotinic acetylcholine receptors

Rudolf Hovius, Horst Vogel, Jörg Grandl, Christophe Danelon

Nicotinic acetylcholine receptors are heteropentameric ion channels that open upon activation to a single conducting state. The second transmembrane segments of each subunit were identified as channel-forming elements, but their respective contribution in ...

2006

Covalent labeling of cell-surface proteins for in-vivo FRET studies

Rudolf Hovius, Horst Vogel, Jean-Manuel Segura, Kai Johnsson, Bruno Meyer, Nathalie George, Pedro Pascoal

Fluorescence resonance energy transfer (FRET) is a powerful technique to reveal interactions between membrane proteins in live cells. Fluorescence labeling for FRET is typically performed by fusion with fluorescent proteins (FP) with the drawbacks of a lim ...

2006

Search for an invisibly-decaying Higgs boson at LEP

Eduardo Sanchez, Horst Vogel, Aurelio Bay, Jian Zhao, Liang Sun, Qian Wang, Zhirui Xu, Matthias Weber, Ji Hyun Kim, Werner Lustermann, Xiao Wang, Zheng Wang

A search for a Higgs boson produced in e(+)e(-) collisions in association with a Z boson and decaying into invisible particles is performed. Data collected at LEP with the U detector at centre-of-mass energies from 189 to 209 GeV are used, corresponding to ...

Elsevier2005

Measurement of the running of the electromagnetic coupling at large momentum-transfer at LEP

Eduardo Sanchez, Horst Vogel, Aurelio Bay, Jian Zhao, Liang Sun, Qian Wang, Zhirui Xu, Matthias Weber, Ji Hyun Kim, Werner Lustermann, Xiao Wang, Zheng Wang

The evolution of the electromagnetic coupling, α, in the momentum-transfer range 1800 GeV2 < -Q2 < 21600 GeV2 is studied with about 40 000 Bhabha-scattering events collected with the L3 detector at LEP at centre-of-mass energies √s = 189-209 GeV. The runni ...

2005

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