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Horst Vogel

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Related publications (116)

Protein-Binding Microarray Analysis of Tumor Suppressor AP2 alpha Target Gene Specificity

Horst Vogel, Nicolas Mermod, Luigino Grasso, Tanja Egener-Kuhn, Jan Kerschgens, Hans-Anton Lehr

Cheap and massively parallel methods to assess the DNA-binding specificity of transcription factors are actively sought, given their prominent regulatory role in cellular processes and diseases. Here we evaluated the use of protein-binding microarrays (PBM ...

Public Library of Science2011

The Mouse Eugenol Odorant Receptor: Structural and Functional Plasticity of a Broadly Tuned Odorant Binding Pocket

Horst Vogel, Horst Pick, Olivia Baud, Sylvain Etter

Molecular interactions of odorants with their olfactory receptors (ORs) are of central importance for the ability of the mammalian olfactory system to detect and discriminate a vast variety of odors with a limited set of receptors. How a particular OR bind ...

American Chemical Society2011

Semisynthesis of fluorescent metabolite sensors on cell surfaces

Horst Vogel, Kai Johnsson, Joachim Piguet, Luc Reymond, Matthias Albert Brun, Kui Thong Tan, Ruud Peters, Rudolf Griss

Progress in understanding signal transduction and metabolic pathways is hampered by a shortage of suitable sensors for tracking metabolites, second messengers, and neurotransmitters in living cells. Here we introduce a class of rationally designed semisynt ...

2011

Deamidation and Transamidation of Substance P by Tissue Transglutaminase Revealed by Electron-Capture Dissociation Fourier Transform Mass Spectrometry (Chem. Eur. J. 2/2011)

Horst Vogel, Luigino Grasso, Adrian Schmid, Yury Tsybin, Luca Fornelli

Tissue transglutaminase (tTGase) catalyzes both deamidation and transamidation of peptides and proteins by using a peptidyl glutamine as primary substrate. A precise consensus sequence for the enzyme is unknown and the ratio between deamidated and transami ...

Wiley-Blackwell2011

Bioanalytical procedure to detect membrane receptor activation

Horst Vogel, Horst Pick

The invention concerns a method for screening compound interaction with transmembrane receptors involved in cellular signal transduction, preferably with G protein coupled receptors, by adding the compound to be analyzed into a medium comprising native inv ...

2010

Membrane nanotubes drawn by optical tweezers transmit electrical signals between mammalian cells over long distances

Horst Vogel, Marinela Gjoni Boillat, Pedro Pascoal, Davor Kosanic

Biological cells continuously change shape allowing essential functions such as cell motility, vesicle-mediated release/uptake of soluble and membrane components or nanotube-mediated cell–cell communications. Here we use single cell micromanipulation to in ...

Royal Society of Chemistry2010

A cytotoxic ruthenium tris(bipyridyl) complex that accumulates at plasma membranes

Michael Graetzel, Horst Vogel, Shaik Mohammed Zakeeruddin, Paul Joseph Dyson, Christophe Danelon, Olivier Pierre Zava

Wiley-Blackwell2009

A synthetic membrane protein in tethered lipid bilayers for immunosensing in whole blood

Solomzi Makohliso, Horst Vogel, Samuel Terrettaz, Stéphanie Follonier

Tethered lipid bilayers, containing a transmembrane synthetic ligand-gated ion channel (SLIC), have been formed on gold surfaces. The SLIC was designed as a highly selective receptor and reporter protein to detect antibodies in whole blood, which are of im ...

Elsevier2009

Dual activities of odorants on olfactory and nuclear hormone receptors

Horst Vogel, Horst Pick, Olivia Baud, Sylvain Etter, Ralf Schmauder

We have screened an odorant compound library and discovered molecules acting as chemical signals that specifically activate both G-protein-coupled olfactory receptors (ORs) on the cell surface of olfactory sensory neurons and the human nuclear estrogen rec ...

American Society for Biochemistry and Molecular Biology2009

Study of the solar anisotropy of cosmic ray primaries of about 200 GeV energy with the L3+C muon detector

Eduardo Sanchez, Horst Vogel, Aurelio Bay, Yu Lei, Jian Zhao, Liang Sun, Qian Wang, Zhirui Xu, Matthias Weber, Ji Hyun Kim, Werner Lustermann, Xiao Wang, Yifei Guo, Xuan Yang, Zheng Wang

Context. Primary cosmic rays experience multiple deflections in the non-uniform galactic and heliospheric magnetic fields which may generate anisotropies. Aims. A study of anisotropies in the energy range between 100 and 500 GeV is performed. This energy r ...

2008

Probing the function of ionotropic and G protein-coupled receptors in surface-confined membranes

Horst Vogel, Samuel Terrettaz, Christophe Danelon

Elsevier2008

Increased Mobility of Major Histocompatibility Complex I-Peptide Complexes Decreases the Sensitivity of Antigen Recognition

Horst Vogel, Jean-Manuel Segura

American Society for Biochemistry and Molecular Biology2008

Real-time high-sensitivity impedance measurement interface for tethered BLM biosensor arrays

Horst Vogel, Samuel Terrettaz, Yusuf Leblebici, Giovanni De Micheli, Luca Benini, Yüksel Temiz, Carlotta Guiducci

This paper presents a switched-capacitor (SC) current integrator circuit for impedance measurement of tethered bilayer lipid membrane (tBLM) biosensors. The circuit comprises a small number of high performance components enabling enhanced experimental flex ...

2008

Refractive multiple optical tweezers for parallel biochemical analysis in micro-fluidics

René Salathé, Horst Vogel, Johann Rohner, Fabrice Merenda, Jean-Marc Fournier

We present a multiple laser tweezers system based on refractive optics. The system produces an array of 100 optical traps thanks to a refractive microlens array, whose focal plane is imaged into the focal plane of a high-NA microscope objective. This refra ...

2007

Study of inclusive strange-baryon production and search for pentaquarks in two-photon collisions at LEP

Eduardo Sanchez, Horst Vogel, Aurelio Bay, Jian Zhao, Liang Sun, Qian Wang, Zhirui Xu, Matthias Weber, Ji Hyun Kim, Werner Lustermann, Xiao Wang, Zheng Wang

2007

Repetitive Reversible Labeling of Proteins at Polyhistidine Sequences for Single-Molecule Imaging in Live Cells

Rudolf Hovius, Horst Vogel, Emmanuel Guignet, Jean-Manuel Segura

Sensitive live-cell fluorescence microscopy and single-molecule imaging are severely limited by rapid photobleaching of fluorescent probes. Herein, we show how to circumvent this problem using a novel, generic labeling strategy. Small nickel-nitrilotriacet ...

2007

Fluorescent Epibatidine Agonists for Neuronal and Muscle-Type Nicotinic Acetylcholine Receptors

Rudolf Hovius, Horst Vogel, Jörg Grandl

Wiley-VCH Verlag GmbH2007

Modulation of proton-induced current fluctuations in the human nicotinic acetylcholine receptor channel

Rudolf Hovius, Horst Vogel, Jörg Grandl, Christophe Danelon

The nicotinic acetylcholine receptor (nAChR) is a ligand-gated ion channel that switches upon activation from a closed state to a full conducting state. We found that the mutation delta S268K, located at 12' position of the second transmembrane domain of t ...

2007

New conjugate of agonist ligand directed to ligand-gated ion channels of cysteine loop-family with chromophore, useful, e.g. in receptor proteins/their interaction with agonistic ligand and to study the effect of unlabelled ligands

Rudolf Hovius, Horst Vogel, Jörg Grandl

NOVELTY - Conjugate (I) of an agonist ligand directed to ligand-gated ion channels (LGICs) of the Cys loop-family with a chromophore, is new. USE - (I) is useful in the receptor proteins and/or their interaction with the agonistic ligand, where the interac ...

2007

Distribution Plasticity of the Human Estrogen Receptor α in Live Cells: Distinct Imaging of Consecutively Expressed Receptors

Horst Vogel, Horst Pick, Hanna Jankevics

Elsevier2007

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