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Theo Lasser

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Related publications (122)

Page 4 of 7

Information Limits of Optical Coherence Imaging Through Scattering Media

Theo Lasser

We develop an information-theoretic framework for the quantitative assessment of the maximum amount of information provided by optical coherence imaging through scattering media. We use our approach to investigate the fundamental dependence of the extracta ...

2009

High-speed multiplane structured illumination microscopy of living cells using an image-splitting prism

Theo Lasser, Aleksandra Radenovic, Vytautas Navikas, Tomas Lukes, Adrien Charles-François Raymond Descloux

Super-resolution structured illumination microscopy (SR-SIM) can be conducted at video-rate acquisition speeds when combined with high-speed spatial light modulators and sCMOS cameras, rendering it particularly suitable for live-cell imaging. If, however, ...

2020

High-speed phase-shifting common-path quantitative phase imaging with a piezoelectric actuator

Theo Lasser, Miguel Sison, Antonio Lopez, Séverine Coquoz

We present a phase-shifting quantitative phase imaging technique providing high temporal and spatial phase stability and high acquisition speed. A piezoelectric microfabricated phase modulator allows tunable modulation frequencies up to the kHz range. Afte ...

SPIE Society of Photo-optical Instrumentation Engineers2016

Resonant Doppler flow imaging and optical vivisection of retinal blood vessels

Theo Lasser, Martin Villiger, Adrian Bachmann, Cédric Blatter

For Fourier domain optical coherence tomography any sample movement during camera integration causes blurring of interference fringes and as such reduction of sensitivity for flow detection. The proposed method overcomes this problem by phase-matching a re ...

2007

How to display data by color schemes compatible with red-green color perception deficiencies

Theo Lasser

Visualization of data concerns most scientists. The use of color is required in order to display multidimensional information. In addition, color encoding a univariate image can improve the interpretation significantly. However up to 10% of the adult male ...

Optical Society of America2013

Method for recording color images and laser direct imaging signals of object, involves generating colored images, where common complementary metal-oxide semiconductor sensor has multiple sensor elements

Theo Lasser

NOVELTY - The method involves generating colored images, where a common complementary metal-oxide semiconductor sensor (7) has multiple sensor elements. A light with different wavelengths is supplied separately for recording color images. A radiation with ...

2009

Imaging of the stroke-related changes in the vascular system of the mouse brain with the use of extended focus Optical Coherence Microscopy

Theo Lasser, Daniel Pawel Szlag

We used Optical Coherence Microscopy (OCM) to monitor structural and functional changes due to ischemic stroke in small animals brains in vivo. To obtain lateral resolution of 2.2 μm over the range of 600 μm we used extended focus configuration of OCM inst ...

SPIE digital Library2016

Quantifying protein densities on cell membranes using super-resolution optical fluctuation imaging

Theo Lasser, Tomas Lukes

Surface molecules, distributed in diverse patterns and clusters on cell membranes, influence vital functions of living cells. It is therefore important to understand their molecular surface organisation under different physiological and pathological condit ...

Nature Research2017

Direct measurement of diffusing proteins in nanochannels using fluorescence correlation spectroscopy

Philippe Renaud, Theo Lasser, Arnaud Bertsch, Nicolas Durand

Transport of proteins in liquid-filled nanometer-sized apertures with charged surfaces based on both diffusion and convective flow is investigated with the use of fluorescence correlation spectroscopy. The measured fluctuations of fluorescence allow the ev ...

Elsevier2009

Zero-crossing approach to high-resolution reconstruction in frequency-domain optical-coherence tomography

Theo Lasser, Marcel Leutenegger, Chandra Sekhar Seelamantula, Arno Pino Bouwens

We address the problem of high-resolution reconstruction in frequency-domain optical-coherence tomography (FDOCT). The traditional method employed uses the inverse discrete Fourier transform, which is limited in resolution due to the Heisenberg uncertainty ...

2012

Solid immersion lens used in a microscope with a lens system is made of a material having a refractive index that is selected so that the numerical aperture of the lens system

Theo Lasser, Ramachandra Rao

The invention relates to a solid immersion lens (SIL) for a microscope, comprising a lens system with a predetermined numerical aperture. The refractive index of the material of the solid immersion lens is selected in such a way that the numerical aperture ...

2005

Laser Doppler imaging for intraoperative human brain mapping

Michaël Unser, Dimitri Nestor Alice Van De Ville, Theo Lasser, Marcel Leutenegger, Erica Martin-Williams

The identification and accurate location of centers of brain activity are vital both in neuro-surgery and brain research. This study aimed to provide a non-invasive, non-contact, accurate, rapid and user-friendly means of producing functional images intrao ...

Elsevier2009

Cumulant microscopy

Theo Lasser, Claudio Dellagiacoma

The invention describes a method and a microscopy system for imaging and analysing stochastically and independently blinking point-like emitters. A multiple-order cumulants analysis in conjunction with an established blinking model enables the extraction o ...

2012

3D Time-lapse Imaging and Quantification of Mitochondrial Dynamics

Theo Lasser, Jérôme Extermann, Antonio Lopez, Paul James Marchand, Miguel Sison

We present a 3D time-lapse imaging method for monitoring mitochondrial dynamics in living HeLa cells based on photothermal optical coherence microscopy and using novel surface functionalization of gold nanoparticles. The biocompatible protein-based biopoly ...

Nature Research2017

Fluorescent Nanodiamond–Gold Hybrid Particles for Multimodal Optical and Electron Microscopy Cellular Imaging

Theo Lasser, Miguel Sison, Weina Liu

There is a continuous demand for imaging probes offering excellent performance in various microscopy techniques for comprehensive investigations. of cellular processes by more than, one technique. FluoreScent nanodianiond gold nanoparticles (END Au) consti ...

American Chemical Society (ACS)2016

NIR-emitting and photo-thermal active nanogold as mitochondria-specific probes

Theo Lasser, Miguel Sison, Jérôme Extermann

We report a bioinspired multifunctional albumin derived polypeptide coating comprising grafted poly(ethylene oxide) chains, multiple copies of the HIV TAT derived peptide enabling cellular uptake as well as mitochondria targeting triphenyl-phosphonium (TPP ...

Royal Soc Chemistry2017

Use of waste products for detecting amyloidogenic proteinaceous material in living mammals

Theo Lasser, Patrick Fraering, Tristan Bolmont, Taoufiq Harach

Method for detecting amyloidogenic proteinaceous material induced by a proteopathy, for instance Alzheimer's disease, characterized by the fact that said amyloidogenic proteinaceous material is detected in a mammal waste product, such as feces. ...

2013

Direct Observation of Transitions between Surface-Dominated and Bulk Diffusion Regimes in Nanochannels

Philippe Renaud, Theo Lasser, Arnaud Bertsch, Nicolas Durand, Claudio Dellagiacoma

The diffusion of charged proteins in liquid-filled nanometer-sized apertures with charged surfaces has been investigated with fluorescence correlation spectroscopy (FCS). Based on a two-dimensional (2D) multicomponent diffusion model, key parameters such a ...

2009

Assessment of transferrin recycling by Triplet Lifetime Imaging in living cells

Harm-Anton Klok, Theo Lasser, Zuzana Kadlecova

An optical method is presented that allows the measurement of the triplet lifetime of a fluorescent molecule. This is a characteristic specific to each fluorophore. Based on differences in triplet lifetimes of two fluorescent species (autofluorescence vers ...

Optical Soc Amer2012

Interferometric synthetic aperture microscopy for extended focus optical coherence microscopy

Theo Lasser, Arno Pino Bouwens, Jérôme Extermann, Paul James Marchand, Séverine Coquoz

Optical coherence microscopy (OCM) is an interferometric technique providing 3D images of biological samples with micrometric resolution and penetration depth of several hundreds of micrometers. OCM differs from optical coherence tomography (OCT) in that i ...

2017