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Theo Lasser

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Related publications (122)

Page 5 of 7

Nonlinear Correlation Spectroscopy (NLCS)

Theo Lasser, Marcel Leutenegger, Luigi Bonacina, Iwan Märki, Noelia Laura Bocchio

We present a novel concept for optical spectroscopy called nonlinear correlation spectroscopy (NLCS). NLCS analyses coherent field fluctuations of the second and third harmonic light generated by diffusing nanoparticles. Particles based on noncentrosymmetr ...

American Chemical Society2012

Diabetes imaging — quantitative assessment of islets of Langerhans distribution in murine pancreas using extended-focus optical coherence microscopy

Dimitri Nestor Alice Van De Ville, Theo Lasser, Anthony Christopher Davison, Anne Grapin-Botton, Martin Villiger, Arno Pino Bouwens, Corinne Berclaz, Erica Martin-Williams, Joan Goulley

Diabetes is characterized by hyperglycemia that can result from the loss of pancreatic insulin secreting β-cells in the islets of Langerhans. We analyzed ex vivo the entire gastric and duodenal lobes of a murine pancreas using extended-focus Optical Cohere ...

2012

Stochastic Approach to Data Analysis in Fluorescence Correlation Spectroscopy

Theo Lasser, Rajesh Langoju, Ramachandra Rao

Fluorescence correlation spectroscopy (FCS) has emerged as a powerful technique for measuring low concentrations of fluorescent molecules and their diffusion constants. In FCS, the experimental data is conventionally fit using standard local search techniq ...

2006

Supervised learning to quantify amyloidosis in whole brains of an Alzheimer's disease mouse model acquired with optical projection tomography

Dimitri Nestor Alice Van De Ville, Theo Lasser, Aleksandra Radenovic, Virginie Sophie Uhlmann, Paul James Marchand, David Nguyen, Arielle Louise Planchette

Alzheimer's disease (AD) is characterized by amyloidosis of brain tissues. This phenomenon is studied with genetically-modified mouse models. We propose a method to quantify amyloidosis in whole 5xFAD mouse brains, a model of AD. We use optical projection ...

2019

Extended focus depth for Fourier domain optical coherence microscopy

Theo Lasser, Adrian Bachmann, Martin Villiger, Lukas Steinmann

We report on a new detection scheme for Fourier domain optical coherence microscopy that exhibits high transverse resolution along an axially extended focal range. Nearly constant transverse resolution of ∼1.5 μm along a focal range of 200 μm is experiment ...

2006

Optical prism for creating multiple views of an image

Theo Lasser, Marcel Leutenegger

Optical prism comprising two external parallel and reflecting surfaces, one internal interface, parallel to said surfaces and acting as light splitter; said prism furthermore comprising an entrance side forming an angle β with respect to said interface and ...

2016

Confining the sampling volume for Fluorescence Correlation Spectroscopy using a sub-wavelength sized aperture

Olivier Martin, Theo Lasser, Patrik Willi Hoffmann, Marcel Leutenegger, Alexandre Perentes

For the observation of single molecule dynamics with fluorescence fluctuation spectroscopy (FFS) very low fluorophore concentrations are necessary. For in vitro measurements, this requirement is easy to fulfill. In biology however, micromolar concentration ...

2006

Real-time full field laser Doppler imaging

Theo Lasser, Marcel Leutenegger, Antonio Lopez, Erica Martin-Williams

We present a full field laser Doppler imaging instrument, which enables real-time in vivo assessment of blood flow in dermal tissue and skin. This instrument monitors the blood perfusion in an area of about 50 cm² with 480 × 480 pixels per frame at a rate ...

2011

High count rates with total internal reflection fluorescence correlation spectroscopy

Theo Lasser, Kai Hassler

We achieved photon count rates per molecule as high as with commonly used confocal fluorescence correlation spectroscopy instruments using a new total internal reflection fluorescence correlation spectroscopy system based on an epi-illumination configurati ...

2005

Fast three-dimensional imaging of gold nanoparticles in living cells with photothermal optical lock-in Optical Coherence Microscopy

Theo Lasser, Christian Santschi, Martin Villiger, Noelia Laura Bocchio, Arno Pino Bouwens, Corinne Berclaz, Joan Goulley, Christophe Pache

We introduce photothermal optical lock-in Optical Coherence Microscopy (poli-OCM), a volumetric imaging technique, which combines the depth sectioning of OCM with the high sensitivity of photothermal microscopy while maintaining the fast acquisition speed ...

Optical Society of America2012

Method for displaying field e.g. tumor, of brain of human patient during surgery of brain, involves acquiring topography data representing topography of field, where output image is displayed based on topography data

Theo Lasser, Marcel Leutenegger, Antonio Lopez, Erica Martin-Williams

NOVELTY - The method involves illuminating a field (11) of brain (13) of a patient for acquiring an image sequence of the field. The field is illuminated after stimulating the patient for acquiring another image sequence. The image sequences are evaluated ...

2010

Three dimensional time lapse imaging of live cell mitochondria with photothermal optical lock-in optical coherence microscopy (Conference Presentation)

Theo Lasser, Jérôme Extermann, Miguel Sison, Christophe Pache

Spie-Int Soc Optical Engineering2016

Method for displaying field of brain of patient during brain surgery involves determining output image from analysis image values and displaying output image

Theo Lasser, Marcel Leutenegger, Antonio Lopez, Erica Martin-Williams

NOVELTY - The display method involves evaluating the sequence of images by: associating a first analysis image value to pixels in the first sequence of images to which pixels of same locations of the field (11) are imaged, respectively; associating a secon ...

2008

Visible spectrum extended-focus optical coherence microscopy for label-free sub-cellular tomography

Theo Lasser, Daniel Pawel Szlag, Arno Pino Bouwens, Jérôme Extermann, Adrien Charles-François Raymond Descloux, Paul James Marchand, Miguel Sison, David Nguyen, Séverine Coquoz

We present a novel extended-focus optical coherence microscope (OCM) attaining 0.7 μm axial and 0.4 μm lateral resolution maintained over a depth of 40 μm, while preserving the advantages of Fourier domain OCM. Our system uses an ultra-broad spectrum from ...

2017

Multiple scattering in optical coherence tomography. II. Experimental and theoretical investigation of cross talk in wide-field optical coherence tomography

Theo Lasser, Marcel Leutenegger, Stéphane Bourquin, Boris Clément Karamata, Markus Laubscher

We present a comprehensive study of multiple-scattering effects in wide-field optical coherence tomography (OCT) realized with spatially coherent illumination. Imaging a sample made of a cleaved mirror embedded in an aqueous suspension of microspheres reve ...

2005

Apparatus and method for detecting and measuring biomolecular interactions

Theo Lasser, Nicolas Durand

A method and system for the rapid detection of biomolecular interactions, the system comprising a sensing platform which comprises a primary support structure including recesses designed to be located in front of a detection unit, said recesses containing ...

2011

Time-resolved Hadamard fluorescence imaging

Theo Lasser, Kai Hassler

We present a new concept for fluorescence lifetime imaging (FLIM) based on time-resolved Hadamard imaging (HI). HI allows image acquisition by use of one single-point detector without requiring a moving scanning stage. Moreover, it reduces the influence of ...

2005

HILBERT TRANSFORM RELATIONS IN FREQUENCY-DOMAIN OPTICAL-COHERENCE TOMOGRAPHIC IMAGING

Theo Lasser, Chandra Sekhar Seelamantula

Interferometric imaging techniques typically embed the object phase information in the magnitude during the measurement process. During reconstruction, the phase is recovered from the magnitude by certain approximations on the measured magnitude and underl ...

2013

IMAGING White-light diffraction tomography

Theo Lasser, Arno Pino Bouwens

Nature Publishing Group2014

Nanofluidic biosensor and its use for rapid measurement of biomolecular interactions in solution and methods

Theo Lasser, Yannick Sébastien Fournier, Nicolas Durand

A method and device for the rapid detection of biomolecules (320) diffusing in a nanometer-confined slit (204) is claimed. In particular, the present invention relates to a novel concept of fluidic side apertures (205) that facilitates the filling of the d ...

2011