Marcel Leutenegger

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Related publications (32)

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Laser Doppler imaging for intraoperative human brain mapping

Michaël Unser, Dimitri Nestor Alice Van De Ville, Theo Lasser, Marcel Leutenegger, Erica Martin-Williams

The identification and accurate location of centers of brain activity are vital both in neuro-surgery and brain research. This study aimed to provide a non-invasive, non-contact, accurate, rapid and user-friendly means of producing functional images intrao ...

Elsevier2009

Nonlinear Correlation Spectroscopy (NLCS)

Theo Lasser, Marcel Leutenegger, Luigi Bonacina, Iwan Märki, Noelia Laura Bocchio

We present a novel concept for optical spectroscopy called nonlinear correlation spectroscopy (NLCS). NLCS analyses coherent field fluctuations of the second and third harmonic light generated by diffusing nanoparticles. Particles based on noncentrosymmetr ...

American Chemical Society2012

Spectral cross-cumulants for multicolor super-resolved SOFI imaging

Theo Lasser, Aleksandra Radenovic, Marcel Leutenegger, Tomas Lukes, Adrien Charles-François Raymond Descloux, Kristin Stefanie Grussmayer

Super-resolution opticalfluctuation imaging provides a resolution beyond the diffraction limitby analysing stochasticfluorescencefluctuations with higher-order statistics. Usingnthorderspatio-temporal cross-cumulants the spatial resolution and the sampling ...

Nature Research2020

Optical prism for creating multiple views of an image

Theo Lasser, Marcel Leutenegger

Optical prism comprising two external parallel and reflecting surfaces, one internal interface, parallel to said surfaces and acting as light splitter; said prism furthermore comprising an entrance side forming an angle β with respect to said interface and ...

2016

Confining the sampling volume for Fluorescence Correlation Spectroscopy using a sub-wavelength sized aperture

Olivier Martin, Theo Lasser, Patrik Willi Hoffmann, Marcel Leutenegger, Alexandre Perentes

For the observation of single molecule dynamics with fluorescence fluctuation spectroscopy (FFS) very low fluorophore concentrations are necessary. For in vitro measurements, this requirement is easy to fulfill. In biology however, micromolar concentration ...

2006

Real-time full field laser Doppler imaging

Theo Lasser, Marcel Leutenegger, Antonio Lopez, Erica Martin-Williams

We present a full field laser Doppler imaging instrument, which enables real-time in vivo assessment of blood flow in dermal tissue and skin. This instrument monitors the blood perfusion in an area of about 50 cm² with 480 × 480 pixels per frame at a rate ...

2011

Method for displaying field e.g. tumor, of brain of human patient during surgery of brain, involves acquiring topography data representing topography of field, where output image is displayed based on topography data

Theo Lasser, Marcel Leutenegger, Antonio Lopez, Erica Martin-Williams

NOVELTY - The method involves illuminating a field (11) of brain (13) of a patient for acquiring an image sequence of the field. The field is illuminated after stimulating the patient for acquiring another image sequence. The image sequences are evaluated ...

2010

Method for displaying field of brain of patient during brain surgery involves determining output image from analysis image values and displaying output image

Theo Lasser, Marcel Leutenegger, Antonio Lopez, Erica Martin-Williams

NOVELTY - The display method involves evaluating the sequence of images by: associating a first analysis image value to pixels in the first sequence of images to which pixels of same locations of the field (11) are imaged, respectively; associating a secon ...

2008

Multiple scattering in optical coherence tomography. II. Experimental and theoretical investigation of cross talk in wide-field optical coherence tomography

Theo Lasser, Marcel Leutenegger, Stéphane Bourquin, Boris Clément Karamata, Markus Laubscher

We present a comprehensive study of multiple-scattering effects in wide-field optical coherence tomography (OCT) realized with spatially coherent illumination. Imaging a sample made of a cleaved mirror embedded in an aqueous suspension of microspheres reve ...

2005

Complementarity of PALM and SOFI for super-resolution live-cell imaging of focal adhesions

Theo Lasser, Aleksandra Radenovic, Marcel Leutenegger, Daniel Pawel Szlag, Tomas Lukes, Hendrik Georges Deschout, Lely Feletti, Azat Sharipov

Live-cell imaging of focal adhesions requires a sufficiently high temporal resolution, which remains a challenge for super-resolution microscopy. Here we address this important issue by combining photoactivated localization microscopy (PALM) with super-res ...

Nature Publishing Group2016

Real-time Full Field Laser Doppler Imaging

Theo Lasser, Marcel Leutenegger

We present a full field laser Doppler imaging instrument that enables real-time in vivo assessment of blood flow in dermal tissue and skin. The instrument monitors the blood perfusion in an area of about 50cm2 with 480 x 480 pixels per frame at a rate of 1 ...

Amer Inst Physics2012

Optical coherence correlation spectroscopy (OCCS)

Theo Lasser, Marcel Leutenegger, Arno Pino Bouwens, Stefan Geissbühler, Christophe Pache, Stéphane Broillet, Akihiro Sato

We present a new method called optical coherence correlation spectroscopy (OCCS) using nanoparticles as reporters of kinetic processes at the single particle level. OCCS is a spectral interferometry based method, thus giving simultaneous access to several ...

Optical Society of America2014