Marcel Leutenegger

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Publications associées (32)

Laser Doppler imaging for intraoperative human brain mapping

Marcel Leutenegger, Michaël Unser, Theo Lasser, Dimitri Nestor Alice Van De Ville, Rainer Leitgeb, Erica Martin-Williams

The identification and accurate location of centers of brain activity are vital both in neuro-surgery and brain research. This study aimed to provide a non-invasive, non-contact, accurate, rapid and user-friendly means of producing functional images intrao ...

Elsevier2009

Method for displaying field of brain of patient during brain surgery involves determining output image from analysis image values and displaying output image

Marcel Leutenegger, Theo Lasser, Antonio Lopez, Erica Martin-Williams

NOVELTY - The display method involves evaluating the sequence of images by: associating a first analysis image value to pixels in the first sequence of images to which pixels of same locations of the field (11) are imaged, respectively; associating a secon ...

2008

Detection efficiency in total internal reflection fluorescence microscopy

Marcel Leutenegger, Theo Lasser

We present a rapid and flexible framework for the accurate calculation of the detection efficiency of fluorescence emission in isotropic media as well as in the vicinity of dielectric or metallic interfaces. The framework accounts for the dipole characteri ...

2008

Single molecule detection on surfaces

Marcel Leutenegger

Monitoring biological relevant reactions on the single molecule level based on fluorescence spectroscopy techniques has become one of the most promising approaches for understanding a variety of phenomena in biophysics, biochemistry and life science. By ap ...

EPFL2007

Fast focus field calculations

Marcel Leutenegger, Theo Lasser, Ramachandra Rao, Rainer Leitgeb

We present a fast calculation of the electromagnetic field near the focus of an objective with a high numerical aperture (NA). Instead of direct integration, the vectorial Debye diffraction integral is evaluated with the fast Fourier transform for calculat ...

2006

Dual-color total internal reflection fluorescence cross- correlation spectroscopy

Marcel Leutenegger, Theo Lasser, Rainer Leitgeb

We present the development and first application of a novel dual-color total internal reflection (TIR) fluorescence system for single-molecule coincidence analysis and fluorescence cross-correlation spectroscopy (FCCS). As a performance analysis, we measur ...

SPIE Society of Photo-optical Instrumentation Engineers2006

Prism-based multicolor fluorescence correlation spectrometer

Marcel Leutenegger, Theo Lasser

We report the design and application of a prism-based detection system for fluorescence (cross) correlation spectroscopy. The system utilizes a single laser wavelength for the simultaneous excitation of several dyes of different emission spectra. Fluoresce ...

2006

Confining the sampling volume for Fluorescence Correlation Spectroscopy using a sub-wavelength sized aperture

Patrik Willi Hoffmann, Marcel Leutenegger, Alexandre Perentes, Theo Lasser, Olivier Martin

For the observation of single molecule dynamics with fluorescence fluctuation spectroscopy (FFS) very low fluorophore concentrations are necessary. For in vitro measurements, this requirement is easy to fulfill. In biology however, micromolar concentration ...

2006

Fabrication of arrays of sub-wavelength nano-apertures in an optically thick gold layer on glass slides for optical studies

Benjamin Dwir, Patrik Willi Hoffmann, Ivo Utke, Marcel Leutenegger, Alexandre Perentes, Theo Lasser

We report on the fabrication of two-dimensional arrays of nano-optical apertures in gold layers by electron beam lithography (EBL) on a transparent glass substrate. 30 x 30 μ m(2) large arrays of high aspect ratio sub-wavelength cylinders (400 nm diameter ...

2005

Total internal reflection fluorescence correlation spectroscopy (TIR-FCS) with low background and high count-rate per molecule

Marcel Leutenegger, Theo Lasser, Kai Hassler, Ramachandra Rao

We designed a fluorescence correlation spectroscopy (FCS) system for measurements on surfaces. The system consists of an objective-type total internal reflection fluorescence (TIRF) microscopy setup, adapted to measure FCS. Here, the fluorescence exciting ...

2005

Multiple scattering in optical coherence tomography. II. Experimental and theoretical investigation of cross talk in wide-field optical coherence tomography

Stéphane Bourquin, Boris Clément Karamata, Marcel Leutenegger, Theo Lasser, Markus Laubscher

We present a comprehensive study of multiple-scattering effects in wide-field optical coherence tomography (OCT) realized with spatially coherent illumination. Imaging a sample made of a cleaved mirror embedded in an aqueous suspension of microspheres reve ...

2005

Multiple scattering in optical coherence tomography. I. Investigation and modeling

Stéphane Bourquin, Boris Clément Karamata, Marcel Leutenegger, Theo Lasser, Markus Laubscher

We present a new model of optical coherence tomography (OCT) taking into account multiple scattering. A theoretical analysis and experimental investigation reveals that in OCT, despite multiple scattering, the field backscattered from the sample is general ...

2005

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