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Horst Vogel

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Related publications (116)

Electrostatic Spray Ionization Mass Spectrometry Imaging

Hubert Girault, Horst Vogel, Horst Pick, Liang Qiao, Elena Tobolkina, Andreas Stephan Lesch, Alexandra Bondarenko, Xiaoqin Zhong

Imaging samples on a surface by mass spectrometry (MS) requires the combination of MS detection with a scanning mode that enables localized desorption and ionization and/or detection of sample analytes with good spatial resolution. We have developed a new ...

Amer Chemical Soc2014

Single-Molecule Microscopy Deciphers the Relation between Trafficking and Signaling of the NK1 Receptor in Livings Cells

Horst Vogel, Joachim Piguet, Luc Veya

Cell Press2014

Monitoring proliferative activities of hormone-like odorants in human breast cancer cells by gene transcription profiling and electrical impedance spectroscopy

Horst Vogel, Samuel Terrettaz, Horst Pick, Olivia Baud, Cathrin Brisken

The human estrogen receptor alpha (ER!) mediates the proliferative action of hormones in breast cancer cells by regulating the expression of target genes to control cellular functions. Current methodologies do not permit a real-time assessment of these pro ...

Elsevier2013

The Role of Water and Sodium Ions in the Activation of the μ-Opioid Receptor

Horst Vogel, Shuguang Yuan

Wiley-VCH Verlag GmbH2013

Tracking NK1 receptor diffusion in the membrane of living cells. Effect of receptor activation

Horst Vogel, Joachim Piguet, Luc Veya

Springer2013

Downscaling the Analysis of Complex Transmembrane Signaling Cascades to Closed Attoliter Volumes

Rudolf Hovius, Horst Vogel, Joachim Piguet, Luigino Grasso, Romain Wyss, Michael Werner, Ghérici Hassaïne

Cellular signaling is classically investigated by measuring optical or electrical properties of single or populations of living cells. Here we show that ligand binding to cell surface receptors and subsequent activation of signaling cascades can be monitor ...

Public Library of Science2013

Thermal Unfolding of a Mammalian Pentameric Ligand-gated Ion Channel Proceeds at Consecutive, Distinct Steps

Henning Paul-Julius Stahlberg, Horst Vogel, Cédric Deluz, Menno Berend Tol, Ghérici Hassaïne

Pentameric ligand-gated ion channels (LGICs) play an important role in fast synaptic signal transduction. Binding of agonists to the beta-sheet-structured extracellular domain opens an ion channel in the transmembrane alpha-helical region of the LGIC. How ...

Amer Soc Biochemistry Molecular Biology Inc2013

Tracking NK1 receptor diffusion in the membrane of living cells. Roles of clathrin and cytoskeleton

Horst Vogel, Joachim Piguet, Luc Veya

Springer2013

Microfluidic single cell analysis with affinity beads

Rudolf Hovius, Horst Vogel, Loïc Arvind Roger Arm, Michael Werner

Springer2013

Large scale expression and purification of the mouse 5-HT3 receptor

Horst Vogel, Cédric Deluz, Menno Berend Tol, Ghérici Hassaïne

Receptors of the Cys-loop family are central to neurotransmission and primary therapeutic targets. In order to decipher their gating and modulation mechanisms, structural data is essential. However, structural studies require large amounts of pure, functio ...

Elsevier Science Bv2013

A Zeptoliter Volume Meter for Analysis of Single Protein Molecules

Horst Vogel, Christian Santschi, Cédric Deluz, Olivier Martin, Romain Wyss, Ghérici Hassaïne

American Chemical Society (ACS)2012

Insertion of T4-lysozyme (T4L) can be a useful tool for studying olfactory-related GPCRs

Horst Vogel, Horst Pick

2012

Individual particle handling in a microfluidic system based on parallel laser trapping

René Salathé, Horst Vogel, Peter Ryser, Mathieu Grossenbacher, Michael Werner, Bastien Rachet

We present an optical trapping system combining individually addressable multiple laser traps with fluorescence spectroscopy. An in-line set of 64 near-IR laser diodes is used to create a line of individually addressable traps inside a microfluidic chip. T ...

Optical Society of America2011

Correlated Optical and Electrical Single-Molecule Measurements Reveal Conformational Diffusion from Ligand Binding to Channel Gating in the Nicotinic Acetylcholine Receptor

Rudolf Hovius, Horst Vogel, Davor Kosanic, Ralf Schmauder

Wiley-Blackwell2011

Overcoming barriers to membrane protein structure determination

Horst Vogel

After decades of slow progress, the pace of research on membrane protein structures is beginning to quicken thanks to various improvements in technology, including protein engineering and microfocus X-ray diffraction. Here we review these developments and, ...

2011

Tissue Transglutaminase-mediated Glutamine Deamidation of beta-Amyloid Peptide Increases Peptide Solubility, Whereas Enzymatic Cross-linking and Peptide Fragmentation May Serve as Molecular Triggers for Rapid Peptide Aggregation

Horst Vogel, Enrico Condemi, Adrian Schmid, Marc Moniatte, Diego Chiappe, Yury Tsybin

Tissue transglutaminase (TGase) has been implicated in a number of cellular processes and disease states, where the enzymatic actions of TGase may serve in both, cell survival and apoptosis. To date, the precise functional properties of TGase in cell survi ...

American Society for Biochemistry and Molecular Biology2011

Bioanalytical reagent, method for production thereof, sensor platforms and detection methods based on use of said bioanalytical reagent

Horst Vogel, Horst Pick

The invention relates to various embodiments of a bioanalytical reagent with at least one vesicle, generated from a living cell, comprising at least one receptor, characterized in that a mechanism of signal transduction triggered by said receptor in the ce ...

2011

Recombinant expression and functional characterization of the mouse olfactory receptor mOR256-17 in mammalian cells

Horst Vogel, Horst Pick, Thamani Dahoun, Luigino Grasso

Olfactory receptors (ORs) constitute the largest family of sensory membrane proteins in mammals. They play a key role within the olfactory system in recognizing and discriminating a nearly unlimited number of structurally diverse odorous molecules. The mol ...

2011

Microfluidic array cytometer based on refractive optical tweezers for parallel trapping, imaging and sorting of individual cells

René Salathé, Horst Vogel, Fabrice Merenda, Joachim Piguet, Michael Werner

Analysis of genetic and functional variability in populations of living cells requires experimental techniques capable of monitoring cellular processes such as cell signaling of many single cells in parallel while offering the possibility to sort interesti ...

Royal Society of Chemistry2011

Acetylcholine Receptor Organization in Membrane Domains in Muscle Cells: EVIDENCE FOR RAPSYN-INDEPENDENT AND RAPSYN-DEPENDENT MECHANISMS

Rudolf Hovius, Horst Vogel, Jean-Manuel Segura, Joachim Piguet, Christoph Schreiter

Nicotinic acetylcholine receptors (nAChR) in muscle fibers are densely packed in the postsynaptic region at the neuromuscular junction. Rapsyn plays a central role in directing and clustering nAChR during cellular differentiation and neuromuscular junction ...

American Society for Biochemistry and Molecular Biology2011

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