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Johan Auwerx

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Publications associées (283)

A guide to analysis of mouse energy metabolism

Johan Auwerx

We present a consolidated view of the complexity and challenges of designing studies for measurement of energy metabolism in mouse models, including a practical guide to the assessment of energy expenditure, energy intake and body composition and statistic ...

2012

Sleep In A Dish: Key Electrophysiological, Molecular, And Metabolic Signatures Of Sleep And Wakefulness Revealed In Primary Cortical Cultures

Cyril Mikhail, Johan Auwerx, Richardus Houtkooper

Amer Acad Sleep Medicine2012

The Corepressor NCoR1 Antagonizes PGC-1α and Estrogen-Related Receptor α in the Regulation of Skeletal Muscle Function and Oxidative Metabolism

Johan Auwerx

Skeletal muscle exhibits a high plasticity and accordingly can quickly adapt to different physiological and pathological stimuli by changing its phenotype largely through diverse epigenetic mechanisms. The nuclear receptor corepressor 1 (NCoR1) has the abi ...

Amer Soc Microbiology2012

Ncor1 is a physiological modulator of muscle mass and oxidative function

Johan Auwerx, Hiroyasu Yamamoto, Laurent Mouchiroud

The present invention provides methods of increasing muscle mass and muscle miochodrial oxidative metabolism. Additionally, the invention provides treating various disorders associated with mitochondrial dysfunction, including but not limited to metabolic ...

2012

The journey of resveratrol from yeast to human

Johan Auwerx

The natural polyphenolic compound resveratrol was first discovered in the 1940s. In the recent years, this compound received renewed interest as several findings implicated resveratrol as a potent SIRT1 activator capable of mimicking the effects of calorie ...

2012

Mitochondrial sirtuins and metabolic homeostasis

Johan Auwerx, Eija Riitta Pirinen, Giuseppe Lo Sasso

The maintenance of metabolic homeostasis requires the well-orchestrated network of several pathways of glucose, lipid and amino acid metabolism. Mitochondria integrate these pathways and serve not only as the prime site of cellular energy harvesting but al ...

Elsevier Sci Ltd2012

TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

Kristina Schoonjans, Johan Auwerx, Mitsunori Nomura, Thijs Pols, Taoufiq Harach, Maaike Hélène Oosterveer, Giuseppe Lo Sasso

The G protein-coupled receptor TGR5 has been identified as an important component of the bile acid signaling network, and its activation has been linked to enhanced energy expenditure and improved glycemic control. Here, we demonstrate that activation of T ...

Cell Press2011

The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation

Kristina Schoonjans, Johan Auwerx, Lilia Noriega Lopez, Mitsunori Nomura, Thijs Pols

Bile acids (BAs) are amphipathic molecules that facilitate the uptake of lipids, and their levels fluctuate in the intestine as well as in the blood circulation depending on food intake. Besides their role in dietary lipid absorption, bile acids function a ...

Elsevier2011

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

Johan Auwerx, Richardus Houtkooper, Dongryeol Ryu

Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here, we treated 11 healthy, obese men with placebo and 150 mg/day resveratrol (r ...

Cell Press2011

NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function

Kristina Schoonjans, Johan Auwerx, Carlos Canto Alvarez, Hiroyasu Yamamoto, Evan Graehl Williams, Laurent Mouchiroud

Transcriptional coregulators control the activity of many transcription factors and are thought to have wide-ranging effects on gene expression patterns. We show here that muscle-specific loss of nuclear receptor corepressor 1 (NCoR1) in mice leads to enha ...

2011

CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability

Johan Auwerx, Lilia Noriega Lopez, Jiujiu Yu, Carlos Canto Alvarez, Chikage Mataki, Hiroyasu Yamamoto

The nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase SIRT1 is a major metabolic regulator activated by energy stresses such as fasting or calorie restriction. SIRT1 activation during fasting not only relies on the increase in the NAD(+)/NAD ...

2011

Don't write sirtuins off

Johan Auwerx, Carlos Canto Alvarez

2011

The bile acid membrane receptor TGR5: a valuable metabolic target

Kristina Schoonjans, Johan Auwerx, Lilia Noriega Lopez, Mitsunori Nomura, Thijs Pols

Bile acids (BAs) are amphipathic molecules that facilitate the uptake of lipids, and their levels fluctuate in the intestines as well as in the circulation depending on food intake. Besides their role in dietary lipid absorption, BAs function as signaling ...

2011

Upstream binding protein 1 polymorphisms and their use for prognosing or diagnosing arterial blood pressure

Johan Auwerx

The present invention is directed to methods for diagnosis and prognosis using polymorphic variants of Ubp 1 s and related probes and kits. ...

2011

Interference between PARPs and SIRT1: a novel approach to healthy ageing?

Johan Auwerx, Carlos Canto Alvarez

Poly(ADP-ribosyl) polymerases (PARPs) have traditionally been linked to chromosome maintenance and DNA repair. Recent findings identify PARPs as key modulators of metabolism through their influence on SIRT1 activity, hinting to a possible role of PARPs as ...

2011

Calorie restriction: is AMPK a key sensor and effector?

Johan Auwerx, Carlos Canto Alvarez

Dietary restriction can extend life span in most organisms tested to date, suggesting that mechanisms sensing nutrient and energy availability might regulate longevity. The AMP-activated protein kinase (AMPK) has emerged as a key energy sensor with the abi ...

2011

Regulation of PGC-1 alpha, a nodal regulator of mitochondrial biogenesis

Johan Auwerx, Pablo Jose Fernandez Marcos

Mechanisms responsible for energy management in the cell and in the whole organism require a complex network of transcription factors and cofactors. Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha) has emerged as a master ...

2011

Ageing: longevity hits a roadblock

Johan Auwerx, Carlos Canto Alvarez

2011

Emerging actions of the nuclear receptor LRH-1 in the gut

Kristina Schoonjans, Johan Auwerx, Pablo Jose Fernandez Marcos

Liver receptor homolog-1 (NR5A2) is a nuclear receptor originally identified in the liver and mostly known for its regulatory role in cholesterol and bile acid homeostasis. More recently, liver receptor homolog-1 has emerged as a key regulator of intestina ...

2011

SRT1720 improves survival and healthspan of obese mice

Johan Auwerx, Carlos Canto Alvarez

Sirt1 is an NAD1-dependent deacetylase that extends lifespan in lower organisms and improves metabolism and delays the onset of age-related diseases in mammals. Here we show that SRT1720, a synthetic compound that was identified for its ability to activate ...

Nature Publishing Group2011

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