Publications by Johan Auwerx | EPFL Graph Search

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Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate, berries, and nuts. UA was discovered 40 years ago, but only recently has its ...

The present invention is directed to methods for diagnosis and prognosis using polymorphic variants of Ubp 1 s and related probes and kits. ...

Abstract of the invention: The present invention relates to agents that induce mitochondrial unfolded protein response (UPR mt ) in muscle stem cells and prevents or reverse process of muscle stem cell senescence. Further, the invention relates to methods ...

Recent improvements in quantitative proteomics approaches, including Sequential Window Acquisition of all Theoretical Mass Spectra (SWATH-MS), permit reproducible large-scale protein measurements across diverse cohorts. Together with genomics, transcriptom ...

Johan Auwerx

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Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

Upstream binding protein 1 polymorphisms and their use for prognosing or diagnosing arterial blood pressure

Agents and methods using thereof for the prevention and treatment of stem cell muscle disorders

Systems proteomics of liver mitochondria function

TGR5 in macrophages is protective against atherosclerosis and insulin resistance

A conserved role of CBP/p300 in mitochondrial stress response and longevity

CycloZ reduces inflammation in bleomycin-induced idiopathic pulmonary fibrosis model mice

ENHANCEMENT OF DE NOVO NAD plus BIOSYNTHESIS BY NOVEL ACMSD INHIBITORS IMPROVES MITOCHONDRIAL FUNCTION IN iPSC-DERIVED HUMAN LIVER ORGANOID MODELS OF STEATOHEPATITIS

Regulation of NAD plus biosynthesis pathway in chronic kidney disease

Ageing: longevity hits a roadblock

An Integrated Systems Genetics and Omics Toolkit to Probe Gene Function

INHIBITING SARM1 IS MORE EFFICACIOUS THAN NICOTINAMIDE RIBOSIDE SUPPLEMENTATION FOR THE TREATMENT OF A MOUSE MODEL WITH NAFLD/NASH

Sex- and age-dependent genetics of longevity in a heterogeneous mouse population

Don't write sirtuins off

ACMSD INHIBITION REDUCES HEPATIC INFLAMMATION AND FIBROSIS IN A MURINE THERMONEUTRALITY MODEL OF NASH

CycloZ improves pulmonary fibrosis in bleomycin-induced idiopathic pulmonary fibrosis model mice by modulating the pathogenic transcriptome