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Johan Auwerx

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Publications associées (283)

A method to identify and validate mitochondrial modulators using mammalian cells and the worm C-elegans

Sabrina Bichet, Johan Auwerx, Richardus Houtkooper, Norman Lionel Moullan, Pénélope Andreux, Adrienne Joëlle Laurence Mottis, Laurent Mouchiroud, Virginija Jovaisaite, Xu Wang

Mitochondria are semi-autonomous organelles regulated by a complex network of proteins that are vital for many cellular functions. Because mitochondrial modulators can impact many aspects of cellular homeostasis, their identification and validation has pro ...

Nature Publishing Group2014

An automated microfluidic platform for long-term high-resolution imaging of C. elegans

Thomas Lehnert, Martinus Gijs, Johan Auwerx, Matteo Cornaglia, Marie-Pierre Meurville, Laurent Mouchiroud, Govindan Narayanan Krishnamani

We describe a microfluidic platform for the automated culture, treatment and long-term highresolution imaging of Caenorhabditis elegans nematodes under normal physiological conditions. Our device features: (i) a microfluidic design tailored for the isolati ...

2014

Super-Resolution Biological Microscopy Using Virtual Imaging by a Microsphere Nanoscope

Martinus Gijs, Johan Auwerx, Norman Lionel Moullan, Hui Yang

Wiley-Blackwell2014

NAD(+)-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease

Johan Auwerx, Eija Riitta Pirinen, Wei Li

Mitochondrial disorders are highly heterogeneous conditions characterized by defects of the mitochondrial respiratory chain. Pharmacological activation of mitochondrial biogenesis has been proposed as an effective means to correct the biochemical defects a ...

Cell Press2014

Mitonuclear protein imbalance as a conserved longevity mechanism

Graham Knott, Elena Katsyuba, Johan Auwerx, Richardus Houtkooper, Norman Lionel Moullan, Dongryeol Ryu, Laurent Mouchiroud

Longevity is regulated by a network of closely linked metabolic systems. We used a combination of mouse population genetics and RNA interference in Caenorhabditis elegans to identify mitochondrial ribosomal protein S5 (Mrps5) and other mitochondrial riboso ...

Nature Publishing Group2013

Methods of treating mitochondrial dysfunction

Johan Auwerx, Richardus Houtkooper, Laurent Mouchiroud

The present invention provides methods of treating various disorders associated with mitochondrial dysfunction, including but not limited to metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, and diseases of aging. ...

2013

Metabolic Characterization of a Sirt5 deficient mouse model

Kristina Schoonjans, Johan Auwerx, Lilia Noriega Lopez, Jiujiu Yu, Norman Lionel Moullan

Sirt5, localized in the mitochondria, is a member of sirtuin family of NAD(+)-dependent deacetylases. Sirt5 was shown to deacetylate and activate carbamoyl phosphate synthase 1. Most recently, Sirt5 was reported to be the predominant protein desuccinylase ...

Nature Publishing Group2013

Bile Acids Increase Levels of MicroRNAs 221 and 222, Leading to Degradation of CDX2 During Esophageal Carcinogenesis

Johan Auwerx

BACKGROUND & AIMS: Bile reflux contributes to development of Barrett's esophagus (BE) and could be involved in its progression to esophageal adenocarcinoma (EAC). We investigated whether bile acids affect levels or functions of microRNAs (MIRs) 221 and 222 ...

Elsevier2013

Hdac6 deletion delays disease progression in the SOD1(G93A) mouse model of ALS

Johan Auwerx

Defects in axonal transport are thought to contribute to the pathogenesis of neurodegenerative disease. Because -tubulin acetylation facilitates axonal transport, inhibition of the -tubulin deacetylating enzymes, histone deacetylase 6 (Hdac6) and silent in ...

Oxford University Press2013

Pharmacological approaches to restore mitochondrial function

Johan Auwerx, Richardus Houtkooper, Pénélope Andreux

Mitochondrial dysfunction is not only a hallmark of rare inherited mitochondrial disorders but also implicated in age-related diseases, including those that affect the metabolic and nervous system, such as type 2 diabetes and Parkinson's disease. Numerous ...

Nature Publishing Group2013

An acetylation rheostat for the control of muscle energy homeostasis

Johan Auwerx, Keir Joe Menzies

In recent years, the role of acetylation has gained ground as an essential modulator of intermediary metabolism in skeletal muscle. Imbalance in energy homeostasis or chronic cellular stress, due to diet, aging, or disease, translate into alterations in th ...

Society for Endocrinology2013

NR5A2 Regulates Lhb and Fshb Transcription in Gonadotrope-Like Cells In Vitro, but Is Dispensable for Gonadotropin Synthesis and Fertility In Vivo

Kristina Schoonjans, Johan Auwerx, Xin Zhou, Vikas Kumar, Yiping Wang

Successful mammalian reproduction depends on proper synthesis of the pituitary-derived glycoprotein hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Several transcription factors cooperate to activate cell-specific and hormone-reg ...

Public Library of Science2013

Probing the Binding Site of Bile Acids in TGR5

Kristina Schoonjans, Johan Auwerx, Thijs Pols

TGR5 is a G-protein-coupled receptor (GPCR) mediating cellular responses to bile acids (BAs). Although some efforts have been devoted to generate homology models of TGR5 and draw structure-activity relationships of BAs, none of these studies has hitherto d ...

American Chemical Society2013

Emerging roles of the corepressors NCoR1 and SMRT in homeostasis

Johan Auwerx, Adrienne Joëlle Laurence Mottis, Laurent Mouchiroud

Epigenetic regulation of gene expression is strongly influenced by the accessibility of nucleosomal DNA or the state of chromatin compaction. In this context, coregulators, including both coactivators and corepressors, are pivotal intermediates that bridge ...

Cold Spring Harbor Laboratory Press2013

Mitochondrial ribosomal proteins as aging regulators

Johan Auwerx, Richardus Houtkooper, Laurent Mouchiroud

The present invention relates to methods of increasing lifespan, delaying aging, and/or preventing or treating an age-related disease or a mitochondrialdisease in a subject, comprising inducing a nuclear-mitochondrial OXPHOS protein dyssynchrony, including ...

2013

Bioavailable copper modulates oxidative phosphorylation and growth of tumors

Carole Poitry-Yamate, Johan Auwerx, Pénélope Andreux, Douglas Hanahan, Seiko Ishida

Copper is an essential trace element, the imbalances of which are associated with various pathological conditions, including cancer, albeit via largely undefined molecular and cellular mechanisms. Here we provide evidence that levels of bioavailable copper ...

National Academy of Sciences2013

Aging biomarkers

Johan Auwerx, Richardus Houtkooper

The present invention relates to novel biomarkers for aging and healthspan, methods and uses thereof, in particular, for determining the biological age of a subject and/or preventing or delaying aging process in a subject, and kits for use in said methods. ...

2013

Impaired myogenesis in estrogen-related receptor γ (ERRγ)-deficient skeletal myocytes due to oxidative stress

Johan Auwerx

Specialized contractile function and increased mitochondrial number and oxidative capacity are hallmark features of myocyte differentiation. The estrogen-related receptors (ERRs) can regulate mitochondrial biogenesis or mitochondrial enzyme expression in s ...

Federation Amer Soc Exp Biol2012

In Vivo Modulation of Mitochondrial Activity Determines HSC Engraftment and Post-Transplant Survival in Mice

Matthias Lütolf, Aline Roch, Nicola Vannini, Johan Auwerx, Richardus Houtkooper, Mukul Girotra, Eija Riitta Pirinen, Olaia Maria Naveiras Torres-Quiroga, Vasco Ledebur de Antas de Campos

Amer Soc Hematology2012

TGR5 in macrophages is protective against atherosclerosis and insulin resistance

Kristina Schoonjans, Johan Auwerx, Mitsunori Nomura, Thijs Pols

Wiley-Blackwell2012

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