Publication

Methods of treating mitochondrial dysfunction

Johan Auwerx, Laurent Mouchiroud, Richardus Houtkooper
2013
Patents

Résumé

The present invention provides methods of treating various disorders associated with mitochondrial dysfunction, including but not limited to metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, and diseases of aging.

Source officielle

https://infoscience.epfl.ch/entities/publication/1076520a-adf9-4261-9986-f2603dd3dcc6

À propos de ce résultat

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Johan Auwerx, Laurent Mouchiroud, Richardus Houtkooper
2013
Patents

Résumé

Source officielle

https://infoscience.epfl.ch/entities/publication/1076520a-adf9-4261-9986-f2603dd3dcc6

À propos de ce résultat

Concepts associés (24)

Aging-associated diseases

An aging-associated disease (commonly termed age-related disease, ARD) is a disease that is most often seen with increasing frequency with increasing senescence. They are essentially complications of senescence, distinguished from the aging process itself because all adult animals age (with rare exceptions) but not all adult animals experience all age-associated diseases. The term does not refer to age-specific diseases, such as the childhood diseases chicken pox and measles, only diseases of the elderly.

Vieillissement

Le vieillissement est l'ensemble des modifications fonctionnelles diminuant progressivement l'aptitude d'un objet, d'une information ou d'un organisme à assurer ses fonctions dans le temps. Dans le cas d'un organisme vivant (être humain par exemple), la plupart des cellules et organes ont une durée de vie maximale génétiquement programmée, mais ce processus peut être accéléré par divers stress subis in utero ou durant la vie - qui conduisent le plus souvent cet organisme à ne plus assurer son équilibre physiologique, ce qui le mène à la mort.

Aging brain

Aging of the brain is a process of transformation of the brain in older age, including changes all individuals experience and those of illness (including unrecognised illness). Usually this refers to humans. Since life extension is only pertinent if accompanied by health span extension, and, more importantly, by preserving brain health and cognition, finding rejuvenating approaches that act simultaneously in peripheral tissues and in brain function is a key strategy for development of rejuvenating technology.

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Publications associées (29)

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Still displaying characteristics of their bacterial origin, such as autonomous division, motility, and their own genome, mitochondria remain an elusive component of modern eukaryotes. They produce most of the cell's energy in the form of adenosine triphosp ...

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The conceptual foundations of innate immunity: Taking stock 30 years later

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While largely neglected over decades during which adaptive immunity captured most of the attention, innate immune mechanisms have now become central to our understanding of immunology. Innate immunity provides the first barrier to infection in vertebrates, ...

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