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Johan Auwerx

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Publications associées (283)

NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

Johan Auwerx, Carlos Canto Alvarez, Keir Joe Menzies

NAD(+) has emerged as a vital cofactor that can rewire metabolism, activate sirtuins, and maintain mitochondrial fitness through mechanisms such as the mitochondrial unfolded protein response. This improved understanding of NAD(+) metabolism revived intere ...

Cell Press2015

Type 5 adenylyl cyclase disruption leads to enhanced exercise performance

Johan Auwerx, Richardus Houtkooper, Laurent Mouchiroud, Jie Zhang

The most important physiological mechanism mediating enhanced exercise performance is increased sympathetic, beta adrenergic receptor (beta-AR), and adenylyl cyclase (AC) activity. This is the first report of decreased AC activity mediating increased exerc ...

Wiley-Blackwell2015

Protective effects of sirtuins in cardiovascular diseases: from bench to bedside

Johan Auwerx

Oxford, Oxford University Press2015

The mitochondrial unfolded protein response - synchronizing genomes

Johan Auwerx, Virginija Jovaisaite

Maintenance of the mitochondrial proteome is performed primarily by chaperones, which fold and assemble proteins, and by proteases, which degrade excess damaged proteins. Upon various types of mitochondrial stress, triggered genetically or pharmacologicall ...

Current Biology Ltd2015

An automated microfluidic platform for C. elegans embryo arraying, phenotyping, and long-term live imaging

Thomas Lehnert, Martinus Gijs, Johan Auwerx, Shreya Narasimhan, Matteo Cornaglia, Laurent Mouchiroud, Alexis Pierre Henri Marette, Virginija Jovaisaite

Studies of the real-time dynamics of embryonic development require a gentle embryo handling method, the possibility of long-term live imaging during the complete embryogenesis, as well as of parallelization providing a population's statistics, while keepin ...

Nature Publishing Group2015

Tetracycline Antibiotics Impair Mitochondrial Function and Its Experimental Use Confounds Research

Johan Auwerx, Richardus Houtkooper, Laurent Mouchiroud

Tetracyclines, a class of antibiotics that target bacterial translation, are commonly used in research for inducible gene expression using Tet-ON/Tet-OFF systems. However, such tetracycline-inducible systems carry a risk. Given that mitochondria have a "ba ...

American Association for Cancer Research2015

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research

Michael Vincent Frochaux, Bart Deplancke, Johan Auwerx, Richardus Houtkooper, Norman Lionel Moullan, Evan Graehl Williams, Dongryeol Ryu, Adrienne Joëlle Laurence Mottis, Laurent Mouchiroud, Virginija Jovaisaite, Xu Wang

In recent years, tetracyclines, such as doxycycline, have become broadly used to control gene expression by virtue of the Tet-on/Tet-off systems. However, the wide range of direct effects of tetracycline use has not been fully appreciated. We show here tha ...

Elsevier2015

The Convergence of Systems and Reductionist Approaches in Complex Trait Analysis

Johan Auwerx, Evan Graehl Williams

Research into the genetic and environmental factors behind complex trait variation has traditionally been segregated into distinct scientific camps. The reductionist approach aims to decrypt phenotypic variability bit by bit, founded on the underlying hypo ...

2015

Intestinal steroidogenesis controls PPAR expression in the colon and is impaired during ulcerative colitis

Johan Auwerx

Background and aims Immune tolerance breakdown during UC involves the peroxisome proliferator-activated receptor- (PPAR), a key factor in mucosal homoeostasis and the therapeutic target of 5-aminosalycilates, which expression is impaired during UC. Here we ...

Bmj Publishing Group2015

A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function

Matthias Alexander Sokrates Stein, Kristina Schoonjans, Johan Auwerx, Dongryeol Ryu, Giuseppe Lo Sasso, Hongbo Zhang, Alessia Perino

Mitochondrial activity is controlled by proteins encoded by both nuclear and mitochondrial DNA. Here, we identify Sirt7 as a crucial regulator of mitochondrial homeostasis. Sirt7 deficiency in mice induces multisystemic mitochondrial dysfunction, which is ...

Cell Press2014

SIRT2 Deficiency Modulates Macrophage Polarization and Susceptibility to Experimental Colitis

Kristina Schoonjans, Johan Auwerx, Hiroyasu Yamamoto, Adrienne Joëlle Laurence Mottis, Giuseppe Lo Sasso, Alessandra Piersigilli, Keir Joe Menzies, Alessia Perino

Background: SIRT2 belongs to a highly conserved family of NAD(+)-dependent deacylases, consisting of seven members (SIRT1-SIRT7), which vary in subcellular localizations and have substrates ranging from histones to transcription factors and enzymes. Recent ...

Public Library of Science2014

An evolutionarily conserved role for the aryl hydrocarbon receptor in the regulation of movement

Michael Vincent Frochaux, Bart Deplancke, Johan Auwerx, Pénélope Andreux, Evan Graehl Williams, Laurent Mouchiroud

The BXD genetic reference population is a recombinant inbred panel descended from crosses between the C57BL/6 (B6) and DBA/2 (D2) strains of mice, which segregate for about 5 million sequence variants. Recently, some of these variants have been established ...

Public Library of Science2014

Mitochondrial Activity Determines Hematopoietic Stem Cell Fate Decisions

Matthias Lütolf, Aline Roch, Nicola Vannini, Johan Auwerx, Mukul Girotra, Olaia Maria Naveiras Torres-Quiroga, Vasco Ledebur de Antas de Campos

Amer Soc Hematology2014

Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle

Kristina Schoonjans, Johan Auwerx, Carlos Canto Alvarez, Norman Lionel Moullan, Evan Graehl Williams, Eija Riitta Pirinen, Laurent Mouchiroud, Hongbo Zhang, Keir Joe Menzies, Laia Morato Fornaguera, Wei Li

We previously demonstrated that the deletion of the poly(ADP-ribose) polymerase (Parp)-1 gene in mice enhances oxidative metabolism, thereby protecting against diet-induced obesity. However, the therapeutic use of PARP inhibitors to enhance mitochondrial f ...

Cell Press2014

Transcriptional Coregulators: Fine-Tuning Metabolism

Johan Auwerx, Laurent Mouchiroud

Metabolic homeostasis requires that cellular energy levels are adapted to environmental cues. This adaptation is largely regulated at the transcriptional level, through the interaction between transcription factors, coregulators, and the basal transcriptio ...

Cell Press2014

The mitochondrial unfolded protein response in mammalian physiology

Johan Auwerx, Adrienne Joëlle Laurence Mottis, Virginija Jovaisaite

Mitochondria, the main site of cellular energy harvesting, are derived from proteobacteria that evolved within our cells in endosymbiosis. Mitochondria retained vestiges of their proteobacterial genome, the circular mitochondrial DNA, which encodes 13 subu ...

Springer Verlag2014

Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer

Elena Katsyuba, Kristina Schoonjans, Johan Auwerx, Dongryeol Ryu, Laurent Mouchiroud, Giuseppe Lo Sasso, Alessandra Piersigilli

Dysfunction of Paneth and goblet cells in the intestine contributes to inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Here, we report a role for the NAD+-dependent histone deacetylase SIRT1 in the control of anti-bacterial ...

Public Library of Science2014

An automated microfluidic platform for reversible immobilization and imaging of C. elegans

Thomas Lehnert, Martinus Gijs, Johan Auwerx, Matteo Cornaglia, Marie-Pierre Meurville, Laurent Mouchiroud, Govindan Narayanan Krishnamani

2014

The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease

Johan Auwerx, Laurent Mouchiroud, Virginija Jovaisaite

The ability to respond to various intracellular and/or extracellular stresses allows the organism to adapt to changing environmental conditions and drives evolution. It is now well accepted that a progressive decline of the efficiency of stress response pa ...

Company of Biologists2014

Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population

Sébastien Dubuis, Ruedi Aebersold, Johan Auwerx, Evan Graehl Williams, Adrienne Joëlle Laurence Mottis, Virginija Jovaisaite

The manner by which genotype and environment affect complex phenotypes is one of the fundamental questions in biology. In this study, we quantified the transcriptome--a subset of the metabolome--and, using targeted proteomics, quantified a subset of the li ...

Cell Press2014

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