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Claudio Bruschini

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Publications associées (185)

Fluorescence lifetime imaging with a megapixel SPAD camera and neural network lifetime estimation

Claudio Bruschini, Edoardo Charbon, Kazuhiro Morimoto, Ming-Lo Wu

Fluorescence lifetime imaging microscopy (FLIM) is a key technology that provides direct insight into cell metabolism, cell dynamics and protein activity. However, determining the lifetimes of different fluorescent proteins requires the detection of a rela ...

NATURE RESEARCH2020

Light microscope with reconfigurable sensor array

Claudio Bruschini, Edoardo Charbon, Ivan Michel Antolovic

A light microscope comprises a light source (10) for illuminating a specimen (35), a sensor array (60) comprised of photon-counting detector elements (61, 62) for measuring detection light (15) coming from the specimen (35), and a control device (70) for c ...

2020

System, device and method for quantum correlation measurement with single photon avalanche diode arrays

Claudio Bruschini, Edoardo Charbon, Ivan Michel Antolovic

A system for photon correlation of an illuminated object and/or a light source, including a light source for illuminating the object or to correlate, an optical system having an object-facing side configured to face the object or the light source and a pro ...

2020

Wide-field time-gated SPAD imager for phasor-based FLIM applications

Claudio Bruschini, Edoardo Charbon, Ivan Michel Antolovic, Arin Can Ülkü, Andrei Ardelean

We describe the performance of a new wide area time-gated single-photon avalanche diode (SPAD) array for phasor-FLIM, exploring the effect of gate length, gate number and signal intensity on the measured lifetime accuracy and precision. We conclude that th ...

IOP2020

Quanta burst photography

Claudio Bruschini, Edoardo Charbon, Arin Can Ülkü, Shantanu Gupta, Mohit Gupta

Single-photon avalanche diodes (SPADs) are an emerging sensor technology capable of detecting individual incident photons, and capturing their time-of-arrival with high timing precision. While these sensors were limited to singlepixel or low-resolution dev ...

2020

Single-Photon, Time-Gated, Phasor-Based Fluorescence Lifetime Imaging through Highly Scattering Medium

Claudio Bruschini, Edoardo Charbon, Arin Can Ülkü

Fluorescence lifetime imaging (FLI) is increasingly recognized as a powerful tool for biochemical and cellular investigations, including in vivo applications. Fluorescence lifetime is an intrinsic characteristic of any fluorescent dye which, to a large ext ...

AMER CHEMICAL SOC2020

Megapixel time-gated SPAD image sensor for 2D and 3D imaging applications

Claudio Bruschini, Edoardo Charbon, Ivan Michel Antolovic, Arin Can Ülkü, Kazuhiro Morimoto, Andrei Ardelean, Ming-Lo Wu

We present a 1 Mpixel single-photon avalanche diode camera featuring 3.8 ns time gating and 24 kips frame rate, fabricated in 180 nm CMOS image sensor technology. We designed two pixels with a pitch of 9.4 mu m in 7 T and 5.75 T configurations respectively ...

2020

Light Extraction Enhancement Techniques for Inorganic Scintillators

Claudio Bruschini, Edoardo Charbon, Nicolas Maxime André Descharmes, Francesco Gramuglia, Simone Frasca, Esteban Venialgo Araujo, Emanuele Ripiccini

2020

Light microscope with photon-counting detector elements and imaging method

Claudio Bruschini, Edoardo Charbon, Ivan Michel Antolovic

A light microscope comprises a light source (10) for illuminating a specimen (35), a photon-counting detector array (60) with a plurality of photon-counting detector elements (61-64) for measuring detection light (15) coming from the specimen (35), wherein ...

2020

CMOS 3D-Stacked FSI Multi-Channel Digital SiPM for Time-of-Flight PET Applications

Claudio Bruschini, Edoardo Charbon, Scott Anthony Lindner, Francesco Gramuglia, Myung Jae Lee, Andrei Ardelean, Andrada Alexandra Muntean, Esteban Venialgo Araujo

2020

Fluorescence lifetime imaging with a single-photon SPAD array using long overlapping gates: an experimental and theoretical study

Claudio Bruschini, Edoardo Charbon, Arin Can Ülkü, Andrei Ardelean

Developing large arrays of single-photon avalanche diodes (SPADs) with on-chip time-correlated single-photon counting (TCSPC) capabilities continues to be a difficult task due to stringent silicon real estate constraints, high data rates and system complex ...

2019

Optical-stack optimization for improved SPAD photon detection efficiency

Claudio Bruschini, Rolando Ferrini, Edoardo Charbon, Frédéric Zanella, Marc Schnieper, Scott Anthony Lindner, Ivan Michel Antolovic, Arin Can Ülkü, Ekin Kizilkan

Single-photon avalanche diodes (SPADs) are direct photon-to-digital detectors that enable scalable arrays with Poisson-limited signal-to-noise ratio and picosecond timing resolution. However, SPAD detectors require a guard-ring structure to prevent lateral ...

2019

First Near-Ultraviolet- and Blue-Enhanced Backside-Illuminated Single-Photon Avalanche Diode Based on Standard SOI CMOS Technology

Claudio Bruschini, Edoardo Charbon, Myung Jae Lee

We present the world's first backside-illuminated (BSI) single-photon avalanche diode (SPAD) based on standard silicon-on-insulator (SOI) complementary metal-oxide semiconductor (CMOS) technology. This SPAD achieves a good dark count rate (DCR) after backs ...

2019

Quantum correlation measurement with single photon avalanche diode arrays

Claudio Bruschini, Edoardo Charbon, Ivan Michel Antolovic

Temporal photon correlation measurement, instrumental to probing the quantum properties of light, typically requires multiple single photon detectors. Progress in single photon avalanche diode (SPAD) array technology highlights their potential as high-perf ...

2019

Single-photon avalanche diode imagers in biophotonics: review and outlook

Claudio Bruschini, Edoardo Charbon, Samuel Burri, Ivan Michel Antolovic, Harald Arjan Robert Homulle

Single-photon avalanche diode (SPAD) arrays are solid-state detectors that offer imaging capabilities at the level of individual photons, with unparalleled photon counting and time-resolved performance. This fascinating technology has progressed at a very ...

2019

A Close-in LiDAR for Diffusive Media based on a 32 × 32 CMOS SPAD Image Sensor

Claudio Bruschini, Edoardo Charbon, Scott Anthony Lindner, Chunmin Zhang, Martin Wolf

2019

A Bit Too Much? High Speed Imaging from Sparse Photon Counts

Claudio Bruschini, Edoardo Charbon, Samuel Burri

Recent advances in photographic sensing technologies have made it possible to achieve light detection in terms of a single photon. Photon counting sensors are being increasingly used in many diverse applications. We address the problem of jointly recoverin ...

IEEE2019

Phasor-based widefield FLIM using a gated 512×512 single-photon SPAD imager

Claudio Bruschini, Edoardo Charbon, Ivan Michel Antolovic, Arin Can Ülkü

Single-photon avalanche diode (SPAD) imagers can perform fast time-resolved imaging in a compact form factor, by exploiting the processing capability and speed of integrated CMOS electronics. Developments in SPAD imagers have recently made them compatible ...

2019

A 512 x 512 SPAD Image Sensor With Integrated Gating for Widefield FLIM

Claudio Bruschini, Edoardo Charbon, Ivan Michel Antolovic, Arin Can Ülkü

In this paper, we report on SwissSPAD2, an image sensor with 512 x 512 photon-counting pixels, each comprising a single-photon avalanche diode (SPAD), a 1-b memory, and a gating mechanism capable of turning the SPAD ON and OFF, with a skew of 250 and 344 p ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2019

Time Domain NIRS Optode based on Null/Small Source-Detector Distance for Wearable Applications

Claudio Bruschini, Edoardo Charbon, Samuel Burri, Sreenil Saha

We present the designs of novel optode based probes integrating light detection and light-pulsing electronics in a single CMOS chip with functional blocks such as a fast pulse-laser driver and synchronized single-photon detection circuit, while exploiting ...

IEEE2019

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