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Claudio Bruschini

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Publications associées (180)

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Widefield High Frame Rate Single-Photon SPAD Imagers for SPIM-FCS

Edoardo Charbon, Claudio Bruschini, Andrei Ardelean, Samuel Burri

Photon-counting sensors based on standard complementary metal-oxide-semiconductor single-photon avalanche diodes (SPADs) represent an emerging class of imagers that enable the counting and/or timing of single photons at zero readout noise (better than high ...

2018

Heralded Spectroscopy: a new single-particle probe for nanocrystal photophysics

Edoardo Charbon, Claudio Bruschini, Samuel Burri, Arin Can Ülkü, Ivan Michel Antolovic

Semiconductor nanocrystals feature multiply-excited states that display intriguing physics and significantly impact nanocrystal-based technologies. Fluorescence supplies a natural probe to investigate these states. Still, direct observation of multiexciton ...

SPIE2023

LinoSPAD2: a 512x1 linear SPAD camera with system-level 135-ps SPTR and a reconfigurable computational engine for time-resolved single-photon imaging

Edoardo Charbon, Claudio Bruschini, Samuel Burri, Arin Can Ülkü, Tommaso Milanese, Ermanno Bernasconi

The LinoSPAD2 camera combines a 512×1 linear single-photon avalanche diode (SPAD) array with an FPGA-based photon-counting and time-stamping platform, to create a reconfigurable sensing system capable of detecting single photons. The read-out is fully para ...

SPIE2023

Double multiplication region configuration for near-infrared sensitivity enhancement in silicon cmos single-photon avalanche diodes

Edoardo Charbon, Claudio Bruschini, Ekin Kizilkan, Utku Karaca

A near-infrared sensitivity enhanced substrate non-isolated silicon single-photon avalanche diode is disclosed, comprising a p-well layer (101), a high-voltage n-well (102), the p-well layer and the high- voltage n-well layer positioned against each other ...

2024

Light microscope with photon-counting detector elements and imaging method

Edoardo Charbon, Claudio Bruschini, Ivan Michel Antolovic

A light microscope comprises a light source (10) for illuminating a specimen (35), a photon-counting detector array (60) with a plurality of photon-counting detector elements (61-64) for measuring detection light (15) coming from the specimen (35), wherein ...

2020

Single-Photon Avalanche Diode for Scalable Particle Detection

Edoardo Charbon, Claudio Bruschini, Francesco Gramuglia, Emanuele Ripiccini, Ekin Kizilkan, Ming-Lo Wu, Jad Benserhir

Single-photon avalanche diodes (SPADs), also referred to as Geiger-mode avalanche photodiodes, are primarily utilized in photon detection and counting. In this work, we present a measurement of the time-of-flight of minimum ionizing particles with outstand ...

IEEE2023

First characterization of the SPADnet sensor: a digital silicon photomultiplier for PET applications

Edoardo Charbon, Claudio Bruschini

Silicon Photomultipliers have the ability to replace photomultiplier tubes when used as light sensors in scintillation gamma-ray detectors. Their timing properties, compactness, and magnetic field compatibility make them interesting for use in Time-of-Flig ...

Iop Publishing Ltd2013

Teaching single-photon detection metrology with off-the-shelf CMOS SPAD detectors

Edoardo Charbon, Claudio Bruschini, Ekin Kizilkan, Utku Karaca

The fabrication of the first CMOS single-photon avalanche diodes (SPADs) back in 2003 paved the way to a range of photodetection applications based on single-photon detection, photon counting, and photon time-stamping. In turn, it has become more and more ...

SPIE2025

High-efficiency fill factor recovery using refractive microlens arrays imprinted on 0.5–256 kpixel front-side illuminated SPAD imagers

Edoardo Charbon, Claudio Bruschini, Ivan Michel Antolovic, Scott Anthony Lindner, Tommaso Milanese, Ermanno Bernasconi, Vladimir Pesic, Frédéric Zanella

Silicon-based single-photon avalanche diodes (SPADs) implemented in front-side illuminated arrays and imagers have often suffered from fill factor limitations. The corresponding reduced sensitivity can be sometimes traded off with longer acquisition times ...

SPIE2023

3D fluorescence molecular tomography utilizing a novel SPAD camera

Edoardo Charbon, Claudio Bruschini, Arin Can Ülkü, Vikash Kumar Pandey

3D Fluorescence Molecular Tomography (FMT) is an important pre-clinical tool for quantifying and characterizing molecular markers for different diseases. Herein, we demonstrate, for the first time, 3D K-Space FMT reconstructions using a large time-gated SP ...

SPIE2024

A Bit Too Much? High Speed Imaging from Sparse Photon Counts

Edoardo Charbon, Claudio Bruschini, Samuel Burri

Recent advances in photographic sensing technologies have made it possible to achieve light detection in terms of a single photon. Photon counting sensors are being increasingly used in many diverse applications. We address the problem of jointly recoverin ...

IEEE2019

Comparison of Two Cameras based on Single Photon Avalanche Diodes (SPADs) for Fluorescence Lifetime Imaging Application with Picosecond Resolution

Edoardo Charbon, Claudio Bruschini, Samuel Burri, Francesco Regazzoni, François Eric Powolny

We report on a comparative study of two time-resolved cameras based on digital Single Photon Avalanche Diodes (SPADs) for Fluorescen ce Lifetime Imaging applications. In contrast to standard imagers such as cameras, SPAD imagers provide intensity as well a ...

2013

Efficient signal extraction for diffuse correlation spectroscopy with SPAD arrays at low photon regimes

Edoardo Charbon, Claudio Bruschini, Michael Alan Wayne

SPAD arrays have shown potential for improving SNR for diffuse correlation spectroscopy in low photon regimes. Here, we will explore different methods of integrating parallelized DCS signals in such regimes for deep blood flow extraction. ...

Optical Society of America2024

NIR fluorescence lifetime macroscopic imaging with a novel time-gated SPAD camera

Edoardo Charbon, Claudio Bruschini

SwissSPAD3 is the latest of a family of widefield time-gated SPAD imagers developed for fluorescence lifetime imaging (FLI) applications. Its distinctive features are (i) the ability to define shorter gates than its predecessors (width W < 1 ns), (ii) supp ...

SPIE2023

Characterizing and exploiting cross-talk effect in SPAD arrays for two-photon interference

Edoardo Charbon, Claudio Bruschini, Tommaso Milanese, Ermanno Bernasconi

SPAD arrays are becoming a popular choice for measuring two-photon interference effects thanks to their high timing precision, fast readout, and high quantum efficiency. However, such sensors are affected by cross-talk that may mimic the useful signal. Eve ...

SPIE2025

Deep learning-based temporal deconvolution for photon time-of-flight distribution retrieval

Edoardo Charbon, Claudio Bruschini, Arin Can Ülkü

The acquisition of the time of flight (ToF) of photons has found numerous applications in the biomedical field. Over the last decades, a few strategies have been proposed to deconvolve the temporal instrument response function (IRF) that distorts the exper ...

2024

SPAD imagers for super resolution localization microscopy enable analysis of fast fluorophore blinking

Edoardo Charbon, Claudio Bruschini, Ivan Michel Antolovic, Samuel Burri

sCMOS imagers are currently utilized (replacing EMCCD imagers) to increase the acquisition speed in super resolution localization microscopy. Single-photon avalanche diode (SPAD) imagers feature frame rates per bit depth comparable to or higher than sCMOS ...

Nature Research2017

Total Ionizing Dose Effects on Analog Performance of 28 nm Bulk MOSFETs

Christian Enz, Claudio Bruschini, Farzan Jazaeri, Chunmin Zhang, Alessandro Pezzotta

This paper uses the simplified charge-based EKV MOSFET model for studying the effects of total ionizing dose (TID) on analog parameters and figures-of-merit (FoMs) of 28nm bulk MOSFETs. These effects are demonstrated to be fully captured by the five key pa ...

2017

EndoTOFPET-US a novel multimodal tool for endoscopy and Positron Emission Tomography

Claudio Bruschini

2012

SPAD Microcells with 12.1 ps SPTR for SiPMs in TOF-PET Applications

Edoardo Charbon, Claudio Bruschini, Francesco Gramuglia, Myung Jae Lee, Ming-Lo Wu

IEEE2021