Publications by Claudio Bruschini

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We present a new probe for radiotracer detection in vivo. The device is based on silicon photomultipliers coupled with a scintillator and wirelessly compensated for supply voltage and temperature variations. The probe is positron sensitive. ...

Semiconductor nanocrystals feature multiply-excited states that display intriguing physics and significantly impact nanocrystal-based technologies. Fluorescence supplies a natural probe to investigate these states. Still, direct observation of multiexciton ...

The LinoSPAD2 camera combines a 512×1 linear single-photon avalanche diode (SPAD) array with an FPGA-based photon-counting and time-stamping platform, to create a reconfigurable sensing system capable of detecting single photons. The read-out is fully para ...

A near-infrared sensitivity enhanced substrate non-isolated silicon single-photon avalanche diode is disclosed, comprising a p-well layer (101), a high-voltage n-well (102), the p-well layer and the high- voltage n-well layer positioned against each other ...

A light microscope comprises a light source (10) for illuminating a specimen (35), a photon-counting detector array (60) with a plurality of photon-counting detector elements (61-64) for measuring detection light (15) coming from the specimen (35), wherein ...

Single-photon avalanche diodes (SPADs), also referred to as Geiger-mode avalanche photodiodes, are primarily utilized in photon detection and counting. In this work, we present a measurement of the time-of-flight of minimum ionizing particles with outstand ...

Silicon Photomultipliers have the ability to replace photomultiplier tubes when used as light sensors in scintillation gamma-ray detectors. Their timing properties, compactness, and magnetic field compatibility make them interesting for use in Time-of-Flig ...

The fabrication of the first CMOS single-photon avalanche diodes (SPADs) back in 2003 paved the way to a range of photodetection applications based on single-photon detection, photon counting, and photon time-stamping. In turn, it has become more and more ...

Silicon-based single-photon avalanche diodes (SPADs) implemented in front-side illuminated arrays and imagers have often suffered from fill factor limitations. The corresponding reduced sensitivity can be sometimes traded off with longer acquisition times ...

3D Fluorescence Molecular Tomography (FMT) is an important pre-clinical tool for quantifying and characterizing molecular markers for different diseases. Herein, we demonstrate, for the first time, 3D K-Space FMT reconstructions using a large time-gated SP ...

Fluorescence lifetime imaging (FLI) offers several advantages, including the quantitative imaging of unique biosignatures in biological tissues, studies of drug-target interactions, and tumor margin identification. However, its adoption in surgical environments has been hindered by the time-consuming data acquisition and processing pipeline. In this work, we present an AI-enhanced rapid lifetime determination (RLD) method utilizing the SwissSPAD3 (SS3) detector, capable of acquiring a single frame to genera

In time-of-flight PET, coincidence time resolution (CTR) of gamma ray detection is essential, with the recent aim of reaching better than 10 ps CTR [1]. Prompt photon emission, e.g. Cherenkov radiation in BGO crystals, has been heralded as a solution to this conundrum. However, Cherenkov detection has low photon yield, prompting high photon detection efficiency and low dark count rate, while achieving fast response with high single-photon time resolution (SPTR) in detectors [2].

We present a 3D quantum enhanced microscope which utilizes the principles of quantum ghost imaging (QGI) to produce volumetric images. This tool is developed to address current challenges in 3D microscopy which include the volumetric capture and tracking of photosensitive samples. Much of the active research on QGI are focused on exploiting the correlative behaviors of the quantum light sources, to obtain higher dimensional data than can be achieved with traditional imaging; in this vein, our study is simil

Recent advances in photographic sensing technologies have made it possible to achieve light detection in terms of a single photon. Photon counting sensors are being increasingly used in many diverse applications. We address the problem of jointly recoverin ...

We report on a comparative study of two time-resolved cameras based on digital Single Photon Avalanche Diodes (SPADs) for Fluorescen ce Lifetime Imaging applications. In contrast to standard imagers such as cameras, SPAD imagers provide intensity as well a ...

SPAD arrays have shown potential for improving SNR for diffuse correlation spectroscopy in low photon regimes. Here, we will explore different methods of integrating parallelized DCS signals in such regimes for deep blood flow extraction. ...

SwissSPAD3 is the latest of a family of widefield time-gated SPAD imagers developed for fluorescence lifetime imaging (FLI) applications. Its distinctive features are (i) the ability to define shorter gates than its predecessors (width W < 1 ns), (ii) supp ...

Quantum ghost imaging uses quantum-entangled photons to generate a two-dimensional image with only a bucket detector at the sample. Here we expand on this approach to generate a three-dimensional image without scanning. A quantum-entangled light source directly links information between a pair of 2D sensors, one of which captures a standard image from one perspective and a second sensor which captures a ghost image from a perpendicular perspective.

SPAD arrays are becoming a popular choice for measuring two-photon interference effects thanks to their high timing precision, fast readout, and high quantum efficiency. However, such sensors are affected by cross-talk that may mimic the useful signal. Eve ...

The acquisition of the time of flight (ToF) of photons has found numerous applications in the biomedical field. Over the last decades, a few strategies have been proposed to deconvolve the temporal instrument response function (IRF) that distorts the exper ...

Claudio Bruschini

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A Compact Probe for Beta+Emitting Radiotracer Detection in Suregery, Biopsy, and Medical Diagnostics based on Silicon Photomultipliers

Heralded Spectroscopy: a new single-particle probe for nanocrystal photophysics

LinoSPAD2: a 512x1 linear SPAD camera with system-level 135-ps SPTR and a reconfigurable computational engine for time-resolved single-photon imaging

Double multiplication region configuration for near-infrared sensitivity enhancement in silicon cmos single-photon avalanche diodes

Light microscope with photon-counting detector elements and imaging method

Single-Photon Avalanche Diode for Scalable Particle Detection

First characterization of the SPADnet sensor: a digital silicon photomultiplier for PET applications

Teaching single-photon detection metrology with off-the-shelf CMOS SPAD detectors

High-efficiency fill factor recovery using refractive microlens arrays imprinted on 0.5–256 kpixel front-side illuminated SPAD imagers

3D fluorescence molecular tomography utilizing a novel SPAD camera

AI-enhanced rapid lifetime determination method for fast macroscopic and mesoscopic fluorescence lifetime imaging

Achieving Sub-20 ps Resolution in Large Arrays of μSiPMs for the DIGILOG Project

3D quantum ghost imaging microscope

A Bit Too Much? High Speed Imaging from Sparse Photon Counts

Comparison of Two Cameras based on Single Photon Avalanche Diodes (SPADs) for Fluorescence Lifetime Imaging Application with Picosecond Resolution

Efficient signal extraction for diffuse correlation spectroscopy with SPAD arrays at low photon regimes

NIR fluorescence lifetime macroscopic imaging with a novel time-gated SPAD camera

3D quantum ghost imaging microscope

Characterizing and exploiting cross-talk effect in SPAD arrays for two-photon interference

Deep learning-based temporal deconvolution for photon time-of-flight distribution retrieval