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Claudio Bruschini

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Publications associées (185)

Fast Two-Photon Interferometer Capable of Spectral Binning for Quantum Telescopy

Claudio Bruschini, Edoardo Charbon, Samuel Burri

We describe a novel type of two-photon interferometer, capable of spectral binning, for quantum-assisted astrometry. We also demonstrated a single-photon spectrometer with spectral and timing resolutions of 0.1 nm and 50 ps, which can be used for this purp ...

Optical Society of America2023

High-efficiency fill factor recovery using refractive microlens arrays imprinted on 0.5–256 kpixel front-side illuminated SPAD imagers

Claudio Bruschini, Edoardo Charbon, Frédéric Zanella, Scott Anthony Lindner, Ivan Michel Antolovic, Vladimir Pesic, Tommaso Milanese

Silicon-based single-photon avalanche diodes (SPADs) implemented in front-side illuminated arrays and imagers have often suffered from fill factor limitations. The corresponding reduced sensitivity can be sometimes traded off with longer acquisition times ...

SPIE2023

On-chip artificial neural network for PET source position reconstruction

Claudio Bruschini, Edoardo Charbon, Emanuele Ripiccini

This work presents the characterization results and methods used to determine the reconstruction of a 22Na point source placed in a coincidence setup. For this purpose, a novel, fully-integrated, reconfigurable feed-forward artificial neural network was im ...

IEEE2023

Single-Photon Avalanche Diode for Scalable Particle Detection

Claudio Bruschini, Edoardo Charbon, Francesco Gramuglia, Ekin Kizilkan, Ming-Lo Wu, Emanuele Ripiccini

Single-photon avalanche diodes (SPADs), also referred to as Geiger-mode avalanche photodiodes, are primarily utilized in photon detection and counting. In this work, we present a measurement of the time-of-flight of minimum ionizing particles with outstand ...

IEEE2023

LinoSPAD2: an FPGA-based , hardware-reconfigurable 512x1 single-photon camera system

Claudio Bruschini, Edoardo Charbon, Samuel Burri, Tommaso Milanese

We report on LinoSPAD2, a single-photon camera system, comprising a 512x1 single-photon avalanche diode (SPAD) front -end and one or two FPGA-based back-ends. Digital signals generated by the SPADs are processed by the FPGA in real time, whereas the FPGA o ...

Optica Publishing Group2023

SoDaCam: Software-defined Cameras via Single-Photon Imaging

Claudio Bruschini, Edoardo Charbon, Andrei Ardelean, Mohit Gupta

Reinterpretable cameras are defined by their post-processing capabilities that exceed traditional imaging. We present "SoDaCam" that provides reinterpretable cameras at the granularity of photons, from photon-cubes acquired by single-photon devices. Photon ...

Ieee Computer Soc2023

SPAD imagers in fluorescence-guided surgical navigation

Claudio Bruschini, Edoardo Charbon

Fluorescence surgical navigation helps surgeons to see molecular information about tissue near the surface and distinguish malignancies from healthy tissue. It is possible to label tumors with specific fluorescent molecules, but not to easily see into tiss ...

SPIE2023

Massively parallel, real-time multispeckle diffuse correlation spectroscopy using a 500 × 500 SPAD camera

Claudio Bruschini, Edoardo Charbon, Francesco Marsili, Arin Can Ülkü, Andrei Ardelean, Paul Mos, Michael Alan Wayne

Diffuse correlation spectroscopy (DCS) is a promising noninvasive technique for monitoring cerebral blood flow and measuring cortex functional activation tasks. Taking multiple parallel measurements has been shown to increase sensitivity, but is not easily ...

2023

Learned Compressive Representations for Single-Photon 3D Imaging

Claudio Bruschini, Edoardo Charbon, Andrei Ardelean, Mohit Gupta

Single-photon 3D cameras can record the time-of-arrival of billions of photons per second with picosecond accuracy. One common approach to summarize the photon data stream is to build a per-pixel timestamp histogram, resulting in a 3D histogram tensor that ...

Ieee Computer Soc2023

Direct MIP detection with sub-10 ps timing resolution Geiger-Mode APDs

Claudio Bruschini, Edoardo Charbon

Elsevier2022

In vitro and in vivo NIR fluorescence lifetime imaging with a time-gated SPAD camera

Claudio Bruschini, Edoardo Charbon, Arin Can Ülkü

Near-infrared (NIR) fluorescence lifetime imaging (FLI) provides a unique contrast mechanism to monitor biological parameters and molecular events in vivo. Single-photon avalanche diode (SPAD) cameras have been recently demonstrated in FLI microscopy (FLIM ...

Optica Publishing Group2022

Sub-10 ps Minimum Ionizing Particle Detection With Geiger-Mode APDs

Claudio Bruschini, Edoardo Charbon, Francesco Gramuglia, Ming-Lo Wu, Carlo Alberto Fenoglio, Emanuele Ripiccini

Major advances in silicon pixel detectors, with outstanding timing performance, have recently attracted significant attention in the community. In this work we present and discuss the use of state-of-the-art Geiger-mode APDs, also known as single-photon av ...

FRONTIERS MEDIA SA2022

NIR Fluorescence lifetime macroscopic imaging with a time-gated SPAD camera

Claudio Bruschini, Edoardo Charbon, Arin Can Ülkü

The performance of SwissSPAD2 (SS2), a large scale, widefield time-gated CMOS SPAD imager developed for fluorescence lifetime imaging, has recently been described in the context of visible range and fluorescence lifetime imaging microscopy (FLIM) of dyes w ...

SPIE-INT SOC OPTICAL ENGINEERING2022

Guard-Ring-Free InGaAs/InP Single-Photon Avalanche Diode Based on a Novel One-Step Zn-Diffusion Technique

Claudio Bruschini, Edoardo Charbon, Myung Jae Lee, Ekin Kizilkan, Utku Karaca, Vladimir Pesic

This work presents a novel InGaAs/InP SPAD structure fabricated using a selective area growth (SAG) method. The surface topography of the selectively grown film deposited within the 70 mu m diffusion apertures is used to engineer the Zn diffusion profile t ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2022

Method and light microscope with a plurality of arrays of photon-counting detector elements

Claudio Bruschini, Edoardo Charbon, Ivan Michel Antolovic

A method for operating a light microscope comprises emitting and guiding a plurality of illumination light beams towards a specimen (6) to form a plurality of separated illumination light spots (2A, 2B, 2C, 2D) at the specimen; and guiding detection light ...

2022

Low-noise high-dynamic-range single-photon avalanche diodes with integrated PQAR circuit in a standard 55 nm BCD

Claudio Bruschini, Edoardo Charbon, Francesco Gramuglia, Myung Jae Lee, Ekin Kizilkan, Pouyan Keshavarzian

Single-photon avalanche diode (SPAD) based sensors and systems enable a variety of applications in biomedical, automotive, consumer, and security domains. While several established standard technologies, which can facilitate the design of SPAD-based system ...

SPIE-INT SOC OPTICAL ENGINEERING2022

Using Heralded Spectrometry to Measure the Biexciton Binding Energy of an Individual Quantum Dot

Claudio Bruschini, Edoardo Charbon, Samuel Burri, Ivan Michel Antolovic, Arin Can Ülkü

Spectrometry of a quantum state of light is a fundamental challenge with practical implications. Here, we demonstrate how such a technique can super-resolve the exciton and biexciton energies in a single quantum dot at room temperature. ...

Optica2022

Characterization of a large Gated SPAD camera for in vivo Macroscopic Fluorescence Lifetime Imaging

Claudio Bruschini

Herein, we report on the utility of a large gated SPAD camera, SwissSPAD2, for preclinical imaging. We demonstrate the ability of SwissSPAD2 to quantify FLI-FRET in tumor xenografts in vivo, in full agreement with gated-ICCD measurements. ...

Optica2022

A Low-noise CMOS SPAD Pixel with 12.1 ps SPTR and 3 ns Dead Time

Claudio Bruschini, Edoardo Charbon, Francesco Gramuglia, Myung Jae Lee, Ming-Lo Wu

In this paper, we present the first CMOS SPAD with performance comparable or better than that of the best custom SPADs, to date. The SPAD-based design, fully integrated in 180 nm CMOS technology, achieves a peak PDP of 55% at 480nm with a very broad spectr ...

2022

A 500 x 500 Dual-Gate SPAD Imager With 100% Temporal Aperture and 1 ns Minimum Gate Length for FLIM and Phasor Imaging Applications

Claudio Bruschini, Edoardo Charbon, Arin Can Ülkü, Andrei Ardelean, Paul Mos, Michael Alan Wayne

In this article, we report on SwissSPAD3 (SS3), a 500 x 500 pixel single-photon avalanche diode (SPAD) array, fabricated in 0.18-mu m CMOS technology. In this sensor, we introduce a novel dual-gate architecture with two contiguous temporal windows, or gate ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2022

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