The surgical treatments of injured soft tissues lead to further injury due to the use of sutures or the surgical routes, which need to be large enough to insert biomaterials for repair. In contrast, the use of low viscosity photopolymerizable hydrogels tha ...

American Chemical Society2022

Intraosseous Injection Of Hydrogel To Locally Increase Bone Density: Osteoporotic Hip Fracture Prevention As Potential Application

Dominique Pioletti, Ulrike Kettenberger

SPRINGER2022

An Injectable Family Of Soft Tissue Hydrogel Adhesives For Knee Applications

Dominique Pioletti, Pierre-Etienne Bourban, Christophe Moser, Céline Samira Wyss, Peyman Karami

MARY ANN LIEBERT, INC2022

Thoughts on cartilage tissue engineering: A 21st century perspective

Dominique Pioletti, Peyman Karami, Theofanis Stampoultzis

In mature individuals, hyaline cartilage demonstrates a poor intrinsic capacity for repair, thus even minor defects could result in progressive degeneration, impeding quality of life. Although numerous attempts have been made over the past years for the ad ...

2021

Feasibility of an alternative method to estimate glenohumeral joint center from videogrammetry measurements and CT/MRI of patients

Dominique Pioletti, Philippe Müllhaupt, Alexandre Terrier, Alain Farron, Matteo Mancuso, Ehsan Sarshari

Videogrammetry is commonly used to record upper limb motions. However, it cannot track the glenohumeral joint center (GH). GH is required to reconstruct upper limb motions. Therefore, it is often estimated by separately measuring scapular motions using sca ...

2021

A Matlab toolbox for scaled-generic modeling of shoulder and elbow

Dominique Pioletti, Philippe Müllhaupt, Alexandre Terrier, Ehsan Sarshari, Yasmine Boulanaache

There still remains a barrier ahead of widespread clinical applications of upper extremity musculoskeletal models. This study is a step toward lifting this barrier for a shoulder musculoskeletal model by enhancing its realism and facilitating its applicati ...

Nature Research2021

Development of Standardized Fetal Progenitor Cell Therapy for Cartilage Regenerative Medicine: Industrial Transposition and Preliminary Safety in Xenogeneic Transplantation

Dominique Pioletti, Sandra Jaccoud, Nathalie Hirt-Burri, Philippe Abdel Sayed, Corinne Scaletta, Salim Elias Darwiche, Alexis Laurent

Diverse cell therapy approaches constitute prime developmental prospects for managing acute or degenerative cartilaginous tissue affections, synergistically complementing specific surgical solutions. Bone marrow stimulation (i.e., microfracture) remains a ...

2021

Pulsatile Flow-Induced Fatigue-Resistant Photopolymerizable Hydrogels for the Treatment of Intracranial Aneurysms

Dominique Pioletti, Andreas Schmocker, Lucio Feo Pancaldi-Giubbini, Christophe Moser, Mahmut Selman Sakar, Oriane Poupart

An alternative intracranial aneurysm embolic agent is emerging in the form of hydrogels due to their ability to be injected in liquid phase and solidify in situ. Hydrogels have the ability to fill an aneurysm sac more completely compared to solid implants ...

2021

An Intrinsically-Adhesive Family of Injectable and Photo-Curable Hydrogels with Functional Physicochemical Performance for Regenerative Medicine

Dominique Pioletti, Pierre-Etienne Bourban, Christophe Moser, Céline Samira Wyss, Naser Nasrollahzadeh Mamaghani, Peyman Karami

Attaching hydrogels to soft internal tissues is crucial for the development of various biomedical devices. Tough sticky hydrogel patches present high adhesion, yet with lack of injectability and the need for treatment of contacting surface. On the contrary ...

WILEY-V C H VERLAG GMBH2021

An Off-the-Shelf Tissue Engineered Cartilage Composed of Optimally Sized Pellets of Cartilage Progenitor/Stem Cells

Dominique Pioletti, Weiliang Shen, Jiayun Huang

Articular cartilage focal lesion remains an intractable challenge in sports medicine, and autologous chondrocytes' implantation (ACI) is one of the most commonly utilized treatment modality for this ailment. However, the current ACI technique requires two ...

AMER CHEMICAL SOC2021

Silk granular hydrogels self-reinforced with regenerated silk fibroin fibers

Dominique Pioletti, Pierre-Etienne Bourban, Céline Samira Wyss, Peyman Karami, Adrien Julien Demongeot

Granular hydrogels with high stability, strength, and toughness are laborious to develop. Post-curing is often employed to bind microgels chemically and enhance mechanical properties. Here a unique strategy was investigated to maintain microgels together w ...

2021

Muscle co-contraction in an upper limb musculoskeletal model: EMG-assisted vs. standard load-sharing

Dominique Pioletti, Philippe Müllhaupt, Alexandre Terrier, Alain Farron, Matteo Mancuso, Ehsan Sarshari

Estimation of muscle forces in over-actuated musculoskeletal models involves optimal distributions of net joint moments among muscles by a standard load-sharing scheme (SLS). Given that co-contractions of antagonistic muscles are counterproductive in the n ...

2021

Hybrid granular hydrogels: combining composites and microgels for extended ranges of material properties

Dominique Pioletti, Pierre-Etienne Bourban, Céline Samira Wyss, Peyman Karami

Developing hydrogels with optimal properties for specific applications is challenging as most of these properties, such as toughness, stiffness, swelling or deformability, are interrelated. The improvement of one property usually comes at the cost of anoth ...

2020

Efficient decellularization of equine tendon with preserved biomechanical properties and cytocompatibility for human tendon surgery indications

Dominique Pioletti, Nathalie Hirt-Burri, Lee Ann Laurent-Applegate, Anthony Grognuz, Cédric Peneveyre, Jens Antons, Pierre-Arnaud Aeberhard

Chronic and acute tendon injuries are frequent afflictions, for which treatment is often long and unsatisfactory. When facing extended injuries, matrices and scaffolds with sufficient biomechanical properties are required for surgical repair and could addi ...

2020

Cross-linkable polymer, hydrogel, and method of preparation thereof

Dominique Pioletti, Pierre-Etienne Bourban, Christophe Moser, Céline Samira Wyss, Peyman Karami

The invention relates to a cross-linkable polymer comprising a base polymer comprising functional groups at least some of which have been reacted with a first organic molecule comprising a cross-linkable unit and with a second organic molecule capable of b ...

2020

Light-Activated, Bioadhesive, Poly(2-hydroxyethyl methacrylate) Brush Coatings

Dominique Pioletti, Harm-Anton Klok, Nariye Cavusoglu Ataman, Peyman Karami, Jian Wang

Rapid adhesion between tissue and synthetic materials is relevant to accelerate wound healing and to facilitate the integration of implantable medical devices. Most frequently, tissue adhesives are applied as a gel or a liquid formulation. This manuscript ...

American Chemical Society2020

In vitro Implementation of Photopolymerizable Hydrogels as a Potential Treatment of Intracranial Aneurysms

Dominique Pioletti, Andreas Schmocker, Christophe Moser, Oriane Poupart

Intracranial aneurysms are increasingly being treated with endovascular therapy, namely coil embolization. Despite being minimally invasive, partial occlusion and recurrence are more frequent compared to open surgical clipping. Therefore, an alternative tr ...

2020

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