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Dominique Pioletti

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Related publications (187)

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Chronic wound healing by fetal cell therapy may be explained by differential gene profiling observed in fetal versus old skin cells

Dominique Pioletti, Corinne Scaletta, Lee Ann Laurent-Applegate, Nathalie Hirt-Burri

Engineering of fetal tissue has a high potential for the treatment of acute and chronic wounds of the skin in humans as these cells have high expansion capacity under simple culture conditions and one organ donation can produce Master Cell Banks which can ...

2009

Micromotion-induced peri-prosthetic fluid flow around a cementless femoral stem

Dominique Pioletti, Alexandre Terrier, Valérie Hélène Emilie Malfroy Camine

Micromotion-induced interstitial fluid flow at the bone-implant interface has been proposed to play an important role in aseptic loosening of cementless implants. High fluid velocities are thought to promote aseptic loosening through activation of osteocla ...

Taylor & Francis2017

Prediction of bone density around orthopedic implants delivering bisphosphonate

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann

The fixation of an orthopedic implant depends strongly upon its initial stability. Peri-implant bone may resorb shortly after the surgery. This resorbtion is directly followed by new bone formation and implants fixation strengthening, the so-called seconda ...

2009

A framework for forward-dynamics simulation of the human shoulder

Dominique Pioletti, Alexandre Terrier, Philippe Müllhaupt, Alain Farron, Ehsan Sarshari

A vast majority of the available biomechanical models of the human shoulder has been developed based on inverse dynamics, e.g. [1,2]. This imposes a number of limitations on their application. For instance, the glenohumeral joint is approximated as an idea ...

2016

Regulation of proliferation and differentiation of human fetal bone cells

Dominique Pioletti, Lee Ann Laurent-Applegate

During the last decade, extensive research has been performed in the field of orthopedic medicine to develop cell-based therapies for the restoration of injured bone tissue. We previously demonstrated that human primary fetal bone cells (HFBCs) associated ...

2011

Human fetal bone cells associated with ceramic reinforced PLA scaffolds for tissue engineering

Dominique Pioletti, Pierre-Etienne Bourban, Corinne Scaletta, Lee Ann Laurent-Applegate, Claire Diane Delabarde, Laurence Marcelle Monique Rivier

Fetal bone cells were shown to have an interesting potential for therapeutic use in bone tissue engineering due to their rapid growth rate and their ability to differentiate into mature osteoblasts in vitro. We describe hereafter their capability to promot ...

2008

Decellularised tissues obtained by a CO2-philic detergent and supercritical CO2

Dominique Pioletti, Pierre-Etienne Bourban, Nathalie Hirt-Burri, Matteo Gregorio Modesto Marascio, Jens Antons, Pierre-Arnaud Aeberhard

Tissue decellularisation has gained much attention in regenerative medicine as an alternative to synthetic materials. In decellularised tissues, biological cues can be maintained and provide cellular environments still unmet by synthetic materials. Supercr ...

2018

Unraveling cartilage degeneration through synergistic effects of hydrostatic pressure and biomimetic temperature increase

Dominique Pioletti, Peyman Karami, Naser Nasrollahzadeh Mamaghani, Yanheng Guo, Theofanis Stampoultzis, Vijay Kumar Rana

Cartilage degeneration, typically viewed as an irreversible, vicious cycle, sees a significant reduction in two essential biophysical cues: the well-established hydrostatic pressure (HP) and the recently discovered transient temperature increase. Our study ...

Cell Press2023

Muscle co-contraction in an upper limb musculoskeletal model: EMG-assisted vs. standard load-sharing

Dominique Pioletti, Alexandre Terrier, Alain Farron, Philippe Müllhaupt, Ehsan Sarshari, Matteo Mancuso

Estimation of muscle forces in over-actuated musculoskeletal models involves optimal distributions of net joint moments among muscles by a standard load-sharing scheme (SLS). Given that co-contractions of antagonistic muscles are counterproductive in the n ...

2021

Effect of temporal onsets of mechanical loading on bone formation inside a tissue engineering scaffold combined with cell therapy

Dominique Pioletti, Tanja Cloé Hausherr

Several approaches to combine bone substitutes with biomolecules, cells or mechanical loading have been explored as an alternative to the limitation and risk-related bone auto- and allo-grafts. In particular, human bone progenitor cells seeded in porous po ...

2018

Augmentation of bone defect healing using a new biocomposite scaffold: an in vivo study in sheep

Dominique Pioletti, Pierre-Etienne Bourban, Laurence Marcelle Monique Rivier

Previous studies support resorbable biocomposites made of poly L-lactic acid (PLA) and β-tricalcium phosphate (TCP) produced by supercritical gas foaming as a suitable scaffold for tissue engineering. The present study was undertaken to demonstrate the bio ...

Elsevier2010

Minimally Invasive Photopolymerization In Intervertebral Disc Tissue Cavities

Dominique Pioletti, Christophe Moser, Pierre-Etienne Bourban, Azadeh Khoushabi, Andreas Schmocker

Photopolymerized hydrogels are commonly used for a broad range of biomedical applications. As long as the polymer volume is accessible, gels can easily be hardened using light illumination. However, in clinics, especially for minimally invasive surgery, it ...

Spie-Int Soc Optical Engineering2014

Impact of synovial fluid flow on temperature regulation in knee cartilage

Dominique Pioletti, Philippe Abdel Sayed, Valérie Hélène Emilie Malfroy Camine, Mohamadreza Nassajian Moghadam

Several studies have reported an increase of temperature in cartilage submitted to cyclic sinusoidal loading. The temperature increase is in part due to the viscous behavior of this tissue, which partially dissipates the input mechanical energy into heat. ...

Elsevier2015

Architecture and properties of anisotropic polymer composite scaffolds for bone tissue engineering

Jan-Anders Edvin Maansson, Dominique Pioletti, Pierre-Etienne Bourban

Bone is a complex porous composite structure with specific characteristics such as viscoelasticity and anisotropy, both in morphology and mechanical properties. Bone defects are regularly filled with artificial tissue grafts, which should ideally have prop ...

2006

Non-setting, injectable biomaterials containing particulate hydroxyapatite can increase primary stability of bone screws in cancellous bone

Dominique Pioletti, Ulrike Kettenberger

BACKGROUND: Fracture fixation in weak bone is still a clinical challenge. Screw augmentation was shown to successfully increase their primary stability. The currently used calcium phosphate or polymeric bone cements, however, present important drawbacks su ...

2018

Efficient decellularization of equine tendon with preserved biomechanical properties and cytocompatibility for human tendon surgery indications

Pierre-Arnaud Aeberhard, Dominique Pioletti, Lee Ann Laurent-Applegate, Nathalie Hirt-Burri, Jens Antons, Anthony Grognuz

Chronic and acute tendon injuries are frequent afflictions, for which treatment is often long and unsatisfactory. When facing extended injuries, matrices and scaffolds with sufficient biomechanical properties are required for surgical repair and could addi ...

2020

3D Printing of Polymers with Hierarchical Continuous Porosity

Dominique Pioletti, Pierre-Etienne Bourban, Matteo Gregorio Modesto Marascio, Jens Antons

Cellular thermoplastic structures with multiscale porosity (1–300 µm microporosity to 0.3–10 mm macroporosity) are produced from an integrated approach of 3D printing by Fused Deposition Modeling printing and Supercritical CO2 Foaming. Porous strands and r ...

Wiley2017

Polylactic Acid–Phosphate Glass Composite Foams as Scaffolds for Bone Tissue Engineering

Jan-Anders Edvin Maansson, Dominique Pioletti, Pierre-Etienne Bourban

Phosphate glass (PG) of the composition 0.46(CaO)–0.04(Na2O)–0.5(P2O5) was used as filler in poly-L-lactic acid (PLA) foams developed as degradable scaffolds for bone tissue engineering. The effect of PG on PLA was assessed both in bulk and porous composit ...

2006

An Intrinsically-Adhesive Family of Injectable and Photo-Curable Hydrogels with Functional Physicochemical Performance for Regenerative Medicine

Dominique Pioletti, Christophe Moser, Pierre-Etienne Bourban, Peyman Karami, Naser Nasrollahzadeh Mamaghani, Céline Samira Wyss

Attaching hydrogels to soft internal tissues is crucial for the development of various biomedical devices. Tough sticky hydrogel patches present high adhesion, yet with lack of injectability and the need for treatment of contacting surface. On the contrary ...

WILEY-V C H VERLAG GMBH2021

Polylactic acid-phosphate glass composite foams as scaffolds for tissue engineering

Jan-Anders Edvin Maansson, Dominique Pioletti, Pierre-Etienne Bourban, Laurence Marcelle Monique Rivier

Phosphate glass (PG) of the composition 0.46(CaO)-0.04(Na(2)O)- 0.5(P(2)O(5)) was used as filler in poly-L-lactic acid (PLA) foams developed as degradable scaffolds for bone tissue engineering. The effect of PG on PLA was assessed both in bulk and porous c ...

2007