Unit

Laboratory of Biophysical Chemistry of Macromolecules

Laboratory

Summary

The Laboratory of Biophysical Chemistry of Macromolecules (LCBM) at EPFL focuses on understanding the molecular organization and function of chromatin and the cytoskeleton. They study the dynamics of chromatin regulation, gene activation, and the chemical biology of chromatin and cytoskeletal proteins. LCBM develops methods to site-specifically introduce post-translational modifications and fluorescent labels into synthetic chromatin fibers to study conformational dynamics. They investigate how proteins find their site of action in the complex cellular environment and collaborate with other units to explore the role of the microtubule network in immune cell tissue invasion and function.

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Laboratory of Biophysical Chemistry of Macromolecules

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From Sequence to Dynamics to Function: Computational Design of Allostery and Ligand Selectivity in G-Protein Coupled Receptors

Computational drug development for membrane protein targets

Investigating the intra-molecular and inter-molecular effects of post-translational modifications on intrinsically disordered protein regions and structured protein regions