Laboratory of Biophysical Chemistry of Macromolecules

The Laboratory of Biophysical Chemistry of Macromolecules (LCBM) at EPFL focuses on understanding the molecular organization and function of chromatin and the cytoskeleton. They study the dynamics of chromatin regulation, gene activation, and the chemical biology of chromatin and cytoskeletal proteins. LCBM develops methods to site-specifically introduce post-translational modifications and fluorescent labels into synthetic chromatin fibers to study conformational dynamics. They investigate how proteins find their site of action in the complex cellular environment and collaborate with other units to explore the role of the microtubule network in immune cell tissue invasion and function.