Angiogenesis inhibition by the maleimide-based small molecule GNX-686

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Related publications (26)

Rapid evaluation of bioactive Ti-based surfaces using an in vitro titration method

Paul Bowen, Jacques Lemaître, Weitian Zhao

The prediction of implant behavior in vivo by the use of easy-to-perform in vitro methods is of great interest in biomaterials research. Simulated body fluids (SBFs) have been proposed and widely used to evaluate the bone-bonding ability of implant materia ...

Springer2019

Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells

Florian Maria Wurm, Nicole Déglon, Bernard Schneider, Vivianne Padrun, Gabriel Vachey, Daniel Roman Blessing

Adeno-associated virus (AAV) vectors are currently among the most commonly applied for in vivo gene therapy approaches. The evaluation of vectors during clinical development requires the production of considerable amounts of highly pure and potent vectors. ...

2019

Impact of MCT1 Haploinsufficiency on the Mouse Retina

Sylvain Eric Lengacher, Pierre Magistretti, Luc Pellerin

The monocarboxylate transporter 1 (MCT1) is highly expressed in the outer retina, suggesting that it plays a critical role in photoreceptors. We examined MCT1+/- heterozygotes, which express half of the normal complement of MCT1. The MCT1(+/-) retina devel ...

SPRINGER INTERNATIONAL PUBLISHING AG2018

Reprogramming tumor blood vessels for enhancing immunotherapy

Michele De Palma

Angiogenic blood vessels contribute to generating an immunosuppressive tumor microenvironment, in part by limiting the extravasation of T cells. Functional reprogramming of angiogenic blood vessels, for example through angiopoietin-2 blockade, may improve ...

2017

System, method and apparatus for retinal absorption phase and dark field imaging with oblique illumination

Christophe Moser, Mathieu Künzi, Dino Carpentras, Timothé Laforest

A method for imaging a tissue of an eye, the method including the steps of providing oblique illumination to the eye by a plurality of light emitting areas of a light delivery device, the plurality of light emitting areas being independently controllable a ...

2017

Subsurface ablation of tissue by ultrafast laser

Thomas Jean Victor Marie Lanvin

Laser-induced optical breakdown (LIOB) is a multiphoton process which can be used for selective removal of material. It revolves around the creation of a plasma in the focal volume of a beam, and requires very high peak intensities in the order of the GW.c ...

EPFL2017

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