Diego Ghezzi

Expertise Neuro-optoelectronic interfaces, visual prosthesis, optical stimulation, microfabrication, polymers, neuroprosthetics, biocompatibility, visual system, sight restoration, sensory perception, artificial photoreceptors Expertise Neuro-optoelectronic interfaces, visual prosthesis, optical stimulation, microfabrication, polymers, neuroprosthetics, biocompatibility, visual system, sight restoration, sensory perception, artificial photoreceptors Mission Our laboratory is a multidisciplinary environment promoting cross-fertilization among various expertise. We bring materials science, engineering, life science, and medicine together by the convergence of physicists, engineers, neuroscientists, and ophthalmologists cooperating to accomplish innovative projects. Our mission is the development of application-driven solutions based on compliant, minimally invasive, and replaceable neuroprosthetic devices. Ultimately, we aim at translating our research findings into clinical practice. Prof. Diego Ghezzi holds the Medtronic Chair in Neuroengineering at the School of Engineering at the Ecole Polytechnique Fédérale de Lausanne. He received his M.Sc. in Biomedical Engineering (2004) and Ph.D. in Bioengineering (2008) from Politecnico di Milano. From 2008 to 2013, he completed his postdoctoral training at Istituto Italiano di Tecnologia in Genova at the Department of Neuroscience and Brain Technologies; where he was promoted to Researcher in 2013. In 2015, he was appointed as Tenure-Track Assistant Professor of Bioengineering at the EPFL Center for Neuroprosthetics and Institute of Bioengineering. Education Ph.D. | Bioengineering 2008 – 2008 Politecnico di Milano Directed by Supervisor Prof. Giancarlo Ferrigno, Department of Bioengineering, Politecnico di Milano, Italy Laurea | Biomedical Engineering 2004 – 2004 Politecnico di Milano Directed by Supervisors Prof. Sara Mantero and Prof. Giancarlo Ferrigno, Department of Bioengineering, Politecnico di Milano, Italy Professionals experiences Researcher 2014–2015 Istituto Italiano di Tecnologia, Genova, ItalyPostdoctoral Fellow 2008–2014 Istituto Italiano di Tecnologia, Genova, Italy ResearchOptic Nerve Stimulation In the last decade, research on vision prosthetics has been focused primarily on retinal prostheses. However, optic nerve represents the preferred point of implantation in order to treat patients not eligible for retinal prostheses (e.g. optic nerve diseases). In our laboratory, we are developing a novel intraneural electrode array (named OpticSELINE) that is effective in inducing the activation of the visual cortex upon electrical stimulation of the optic nerve. The OpticSELINE induces selective cortical activation patterns depending on the stimulating electrode, thus suggesting that it possesses spatial selectivity in fiber stimulation.Retinal Prosthesis Inspired by intraocular lenses, we have designed a foldable and photovoltaic wide-field epiretinal prosthesis (named POLYRETINA) capable of stimulating wireless retinal ganglion cells. Within a visual angle of 46.3 degrees, POLYRETINA embeds more than 6000 stimulating pixels, it is foldable to allow implantation through a small scleral incision, and it has a hemispherical shape to match the curvature of the eye. We demonstrate that it is not cytotoxic and respects optical and thermal safety standards; accelerated aging shows a lifetime of at least 2 years. POLYRETINA represents a significant progress towards the improvement of both visual acuity and visual field with the same device, a current challenging issue in the field.