Publication

Reprogramming tumor blood vessels for enhancing immunotherapy

Michele De Palma
2017
Journal Articles

Abstract

Angiogenic blood vessels contribute to generating an immunosuppressive tumor microenvironment, in part by limiting the extravasation of T cells. Functional reprogramming of angiogenic blood vessels, for example through angiopoietin-2 blockade, may improve T cell trafficking in tumors and the efficacy of immune checkpoint blockade (ICB) and other cancer immunotherapies.

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Reprogramming tumor blood vessels for enhancing immunotherapy

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