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Related publications (122)

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Proton T(1) relaxation times of metabolites in human occipital white and gray matter at 7 T

Rolf Gruetter, Lijing Xin, Benoît Schaller, Huanxiang Lu

Proton T(1) relaxation times of metabolites in the human brain have not previously been published at 7 T. In this study, T(1) values of CH(3) and CH(2) group of N-acetylaspartate and total creatine as well as nine other brain metabolites were measured in o ...

Wiley-Blackwell2013

Improved reproducibility of γ-aminobutyric acid measurement from short-echo-time proton MR spectroscopy by linewidth-matched basis sets in LCModel

Lijing Xin, Bernard Lanz, Ying Xiao, Songi Lim

gamma-Aminobutyric acid (GABA), as the primary inhibitory neurotransmitter, is extremely important for maintaining healthy brain function, and deviations from GABA homeostasis are related to various brain diseases. Short-echo-time (short-TE) proton MR spec ...

Wiley2023

In vivo quantification of neuro-glial metabolism and glial glutamate concentration using 1H-[13C] MRS at 14.1T

Rolf Gruetter, Lijing Xin, Bernard Lanz

Astrocytes have recently become a major center of interest in neurochemistry with the discoveries on their major role in brain energy metabolism. An interesting way to probe this glial contribution is given by in vivo 13C NMR spectroscopy coupled with the ...

Wiley-Blackwell2014

Improved off‐resonance phase behavior using a phase‐inverted adiabatic half‐passage pulse for 13 C MRS in humans at 7 T

Rolf Gruetter, Lijing Xin, Daniel Gallichan, Eulalia Serés Roig

In vivo (13) C MRS at high field benefits from an improved SNR and spectral resolution especially when using surface coils in combination with adiabatic pulses, such as the adiabatic half-passage (AHP) pulse for (13) C excitation. However, the excitation p ...

2019

Lactate measurement by neurochemical profiling in the dorsolateral prefrontal cortex at 7T: accuracy, precision, and relaxation times

Pierre Magistretti, Lijing Xin, Masoumeh Dehghani Moghadam

Purpose This assesses the potential of measuring lactate in the human brain using three non-editing MRS methods at 7T and compares the accuracy and precision of the methods. Methods H-1 MRS data were measured in the right dorsolateral prefrontal cortex usi ...

Wiley2020

Metabolite concentration changes associated with positive and negative BOLD responses in the human visual cortex: A functional MRS study at 7 Tesla

Rolf Gruetter, Lijing Xin, Wietske Van der Zwaag, Yohan Boillat

Negative blood oxygenation-level dependent (BOLD) signal observed during task execution in functional magnetic resonance imaging (fMRI) can be caused by different mechanisms, such as a blood-stealing effect or neuronal deactivation. Electrophysiological re ...

2019

Fast 3D 31P B1+ mapping with a weighted stack of spiral trajectory at 7 T

Salomé Sophie Célestine Baup, Lijing Xin, Katarzyna Pierzchala, Daniel Wenz, Mark Stephan Widmaier, Ying Xiao, Zhiwei Huang, Antonia Kaiser

Purpose: Phosphorus MRS (31P MRS) enables noninvasive assessment of energy metabolism, yet its application is hindered by sensitivity limitations. To overcome this, often high magnetic fields are used, leading to challenges such as spatial (Formula present ...

Wiley2025

Glutathione in the nucleus accumbens regulates motivation to exert reward-incentivized effort

Maria del Carmen Sandi Perez, Lijing Xin, Olivia Zanoletti, João Pedro de Matos Rodrigues, Fiona Hollis, Pascal Steiner, Simone Astori, Ioannis Zalachoras, Alina Veronika Irene Strasser, Eva Ramos Fernandez

Emerging evidence is implicating mitochondrial function and metabolism in the nucleus accumbens in motivated performance. However, the brain is vulnerable to excessive oxidative insults resulting from neurometabolic processes, and whether antioxidant level ...

2022

MRI characterization of in vitro clots at 3T and 7T: A technical note

Lijing Xin, François Lazeyras

In acute ischemic stroke, the composition of the occlusive clot can be associated with the underlying pathophysiology and the response to treatment. For these reasons, it is important to characterize the clot composition from clinical scans. We examine the ...

Masson Editeur2024

Five percent CO2 inhalation alleviates hippocampal glutamate and water homeostasis disturbance, neuronal damage, and learning-memory impairment in sleep-deprived rats

Lijing Xin

Background: Sleep deprivation causes hippocampal injury, manifesting as neuronal damage and learning-memory impairment. These negative effects may be associated with disturbance of hippocampal glutamate and water homeostasis, which induces excessive neuron ...

2024

In vivo magnetic resonance P-31-Spectral Analysis With Neural Networks: 31P-SPAWNN

Lijing Xin, François Lazeyras, Sébastien Courvoisier

Purpose: We have introduced an artificial intelligence framework, 31P-SPAWNN, in order to fully analyze phosphorus-31 (P-31) magnetic resonance spectra. The flexibility and speed of the technique rival traditional least-square fitting methods, with the per ...

WILEY2022

Cannabis use in early psychosis is associated with reduced glutamate levels in the prefrontal cortex

Rolf Gruetter, Lijing Xin

Recent studies have shown that cannabis may disrupt glutamate (Glu) signaling depressing Glu tone in frequent users. Current evidence have also consistently reported lower Glu-levels in various brain regions, particularly in the medial prefrontal cortex (m ...

Springer Verlag2018

H-1 NMR spectroscopy of rat brain in vivo at 14.1 Tesla: Improvements in quantification of the neurochemical profile

Rolf Gruetter, Cristina Ramona Cudalbu Moldovan, Lijing Xin

Ultra-short echo-time proton single voxel spectra of rat brain were obtained on a 14.1 T 26 cm horizontal bore system. At this field, the fitted linewidth in the brain tissue of adult rats was about 11 Hz. New, separated resonances ascribed to phosphocholi ...

Academic Press Inc - Elsevier Science2008

Advanced single voxel 1 H magnetic resonance spectroscopy techniques in humans: Experts' consensus recommendations

Lijing Xin

Conventional proton MRS has been successfully utilized to noninvasively assess tissue biochemistry in conditions that result in large changes in metabolite levels. For more challenging applications, namely, in conditions which result in subtle metabolite c ...

2020

In vivo P-31 magnetic resonance spectroscopy study of mouse cerebral NAD content and redox state during neurodevelopment

Lijing Xin

Nicotinamide adenine dinucleotide (NAD) is an important cofactor of energy-producing pathways. The redox ratio (NAD(+)/NADH) reflects the cellular oxidoreductive state. Oxidative stress and redox dysregulation have been suggested to contribute to various n ...

NATURE RESEARCH2020

Quantification of the neurochemical profile using simulated macromolecule resonances at 3 T

Rolf Gruetter, Cristina Ramona Cudalbu Moldovan, Lijing Xin, Benoît Schaller

The broad resonances underlying the entire (1) H NMR spectrum of the brain, ascribed to macromolecules, can influence metabolite quantification. At the intermediate field strength of 3 T, distinct approaches for the determination of the macromolecule signa ...

Wiley-Blackwell2013

Dipolectric antenna for high-field MRI

Lijing Xin, Daniel Wenz

Purpose: To introduce the dipolectric antenna: a novel RF coil design for high-field MRI using a combination of a dipole antenna with a loop-coupled dielectric resonator antenna. ...

WILEY2023

Magnetic Resonance Spectroscopy in Schizophrenia: Evidence for Glutamatergic Dysfunction and Impaired Energy Metabolism

Lijing Xin, João Miguel das Neves Duarte

In the past couple of decades, major efforts were made to increase reliability of metabolic assessments by magnetic resonance methods. Magnetic resonance spectroscopy (MRS) has been valuable for providing in vivo evidence and investigating biomarkers in ne ...

2019

Variability and magnitude of brain glutamate levels in schizophrenia: a meta and mega-analysis

Lijing Xin

Glutamatergic dysfunction is implicated in schizophrenia pathoaetiology, but this may vary in extent between patients. It is unclear whether inter-individual variability in glutamate is greater in schizophrenia than the general population. We conducted met ...

SPRINGERNATURE2023

H-1-[C-13] NMR Spectroscopy of the Rat Brain During Infusion of [2-C-13] Acetate at 14.1 T

Rolf Gruetter, Lijing Xin, Bernard Lanz

Full signal intensity H-1-[C-13] NMR spectroscopy, combining a preceding C-13-editing block based on an inversion BISEP (B-1-insensitive spectral editing pulse) with a spin-echo coherence-based localization, was developed and implemented at 14.1 T. C-13 ed ...

Wiley-Blackwell2010