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In acute ischemic stroke, the composition of the occlusive clot can be associated with the underlying pathophysiology and the response to treatment. For these reasons, it is important to characterize the clot composition from clinical scans. We examine the ...

Background: Sleep deprivation causes hippocampal injury, manifesting as neuronal damage and learning-memory impairment. These negative effects may be associated with disturbance of hippocampal glutamate and water homeostasis, which induces excessive neuron ...

Purpose: We have introduced an artificial intelligence framework, 31P-SPAWNN, in order to fully analyze phosphorus-31 (P-31) magnetic resonance spectra. The flexibility and speed of the technique rival traditional least-square fitting methods, with the per ...

Recent studies have shown that cannabis may disrupt glutamate (Glu) signaling depressing Glu tone in frequent users. Current evidence have also consistently reported lower Glu-levels in various brain regions, particularly in the medial prefrontal cortex (m ...

Ultra-short echo-time proton single voxel spectra of rat brain were obtained on a 14.1 T 26 cm horizontal bore system. At this field, the fitted linewidth in the brain tissue of adult rats was about 11 Hz. New, separated resonances ascribed to phosphocholi ...

Conventional proton MRS has been successfully utilized to noninvasively assess tissue biochemistry in conditions that result in large changes in metabolite levels. For more challenging applications, namely, in conditions which result in subtle metabolite c ...

Nicotinamide adenine dinucleotide (NAD) is an important cofactor of energy-producing pathways. The redox ratio (NAD(+)/NADH) reflects the cellular oxidoreductive state. Oxidative stress and redox dysregulation have been suggested to contribute to various n ...

The broad resonances underlying the entire (1) H NMR spectrum of the brain, ascribed to macromolecules, can influence metabolite quantification. At the intermediate field strength of 3 T, distinct approaches for the determination of the macromolecule signa ...

Purpose: To introduce the dipolectric antenna: a novel RF coil design for high-field MRI using a combination of a dipole antenna with a loop-coupled dielectric resonator antenna. ...

Glutamatergic dysfunction is implicated in schizophrenia pathoaetiology, but this may vary in extent between patients. It is unclear whether inter-individual variability in glutamate is greater in schizophrenia than the general population. We conducted met ...

Full signal intensity H-1-[C-13] NMR spectroscopy, combining a preceding C-13-editing block based on an inversion BISEP (B-1-insensitive spectral editing pulse) with a spin-echo coherence-based localization, was developed and implemented at 14.1 T. C-13 ed ...

The purposes of the current study were to introduce a Mescher-Garwood (MEGA) semi-adiabatic spin-echo full-intensity localization (MEGA-sSPECIAL) sequence with macromolecule (MM) subtraction and to compare the test-retest reproducibility of gamma-aminobuty ...

The brain requires a large amount of energy, mostly derived from the metabolism of glucose, which decreases substantially with age and neurological diseases. While mounting evidence in model organisms illustrates the central role of brain nicotinamide aden ...

To determine whether glycine can be measured at 7 T in human brain with H-1 magnetic resonance spectroscopy (MRS). ...

Purpose Carbon-13 magnetic resonance spectroscopy (13C-MRS) is challenging because of the inherent low sensitivity of 13C detection and the need for radiofrequency transmission at the 1H frequency while receiving the 13C signal, the latter requiring electr ...

We have recently shown that at isotopic steady state C-13 NMR can provide a direct measurement of glycogen concentration changes, but that the turnover of glycogen was not accessible with this protocol. The aim of the present study was to design, implement ...

Recent studies at high field (7 Tesla) have reported small metabolite changes, in particular lactate and glutamate (below 0.3 μmol/g) during visual stimulation. These studies have been limited to the visual cortex because of its high energy metabolism and ...

Lijing Xin

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MRI characterization of in vitro clots at 3T and 7T: A technical note

Five percent CO2 inhalation alleviates hippocampal glutamate and water homeostasis disturbance, neuronal damage, and learning-memory impairment in sleep-deprived rats

In vivo magnetic resonance P-31-Spectral Analysis With Neural Networks: 31P-SPAWNN

Cannabis use in early psychosis is associated with reduced glutamate levels in the prefrontal cortex

H-1 NMR spectroscopy of rat brain in vivo at 14.1 Tesla: Improvements in quantification of the neurochemical profile

Advanced single voxel 1 H magnetic resonance spectroscopy techniques in humans: Experts' consensus recommendations

In vivo P-31 magnetic resonance spectroscopy study of mouse cerebral NAD content and redox state during neurodevelopment

Quantification of the neurochemical profile using simulated macromolecule resonances at 3 T

Dipolectric antenna for high-field MRI

Variability and magnitude of brain glutamate levels in schizophrenia: a meta and mega-analysis

H-1-[C-13] NMR Spectroscopy of the Rat Brain During Infusion of [2-C-13] Acetate at 14.1 T

gamma-aminobutyric acid measurement in the human brain at 7 T: Short echo-time or Mescher-Garwood editing

Redox Dysregulation, Myelination Deficit and Dysconnectivity in Schizophrenia: A Translational Study in First Episode Patients and Experimental Models

Brain NAD Is Associated With ATP Energy Production and Membrane Phospholipid Turnover in Humans

In vivo measurement of glycine with short echo-time H-1 MRS in human brain at 7 T

Genetic Association with Prefrontal Glutathione Deficit: A 3T 1H MRS Study in Early Psychosis

A double-quadrature radiofrequency coil design for proton-decoupled carbon-13 magnetic resonance spectroscopy in humans at 7T

Quantification of brain glycogen concentration and turnover through localized C-13 NMR of both the C1 and C6 resonances

Are glutamate and lactate increases ubiquitous to physiological activation? A 1H functional MR spectroscopy study during motor activation in human brain at 7Tesla

Neurometabolism in Grey Matter of Children With Chronic Liver Disease or Portosystemic Shunting: A 1H-MRS Study at 7T