Cristina Ramona Cudalbu Moldovan

Expertise In vivo proton, phosphorus, carbon and nitrogen MR Spectroscopy   Chronic Hepatic Encephalopathy, Hyperammonemia - https://actu.epfl.ch/news/when-liver-disease-affects-the-brain/   Brain metabolites quantification and macromolecules   In vivo proton Spectroscopic Imaging   Magnetic Resonance Imaging, Diffusion Weighted Imaging   Brain tumors   Dynamic nuclear polarization Scholar google ‪Cristina Cudalbu‬ - ‪Google Scholar‬ Current work Development: implement/validate new acquisition and quantification techniques for in vivo proton, phosphorous, carbon, nitrogen MRS    Implement new acquisition techniques for fast spectroscopic imaging and diffusion spectroscopy    Implement new techniques for brain macromolecules quantificationAnimal models:   Chronic liver failure/chronic hepatic encephalopathy   - https://www.youtube.com/watch?v=SYkzgkbJGiY   - characterize the developing brain under chronic hepatic encephalopathy       - mechanistic understanding of chronological event involved in chronic hepatic encephalopathy and targeted treatments using a multi-modal approach   Brain tumors   Creatine deficiencies, etc PubMed https://www.ncbi.nlm.nih.gov/pubmed/?term=cudalbu Cristina Cudalbu obtained her Bachelors of Science degree in Medical Physics in 2002 and Masters of Science degree in Biophysics and Medical Physics in 2003, both from University Babes-Bolyai, Cluj-Napoca, Romania. In 2006 she obtained her PhD degree in Localized Proton MRS and time domain quantification of cerebral metabolites at 7T and 4.7T at University Lyon 1, RMN Laboratory, Villeurbanne, France.In 2007, she joined, as a Scientist, the Laboratory for Functional and Metabolic Imaging at EPFL, where she implemented new acquisition and quantification techniques for in vivo nitrogen, proton and carbon MRS for preclinical studies. Starting 2012, Cristina Cudalbu was appointed as Research Staff Scientist and 9.4T MRI Operational Manager at Centre d'Imagerie Biomédicale (CIBM) at EPFL. In 2021, Cristina Cudalbu was promoted to Research and Teaching Associate in the Faculty of Basic Sciences at EPFL and is leading the MRS4Brain Group. In 2023 Cristina Cudalbu was promoted to Deputy Head at CIBM MRI EPFL AIT and in 2024 to Maître d'enseignement et de recherche (MER) at School of Basic Sciences at EPFL. In 2025 she became Head of CIBM PCI EPFL. Over the last decade, she has been developing new research lines at CIBM which are oriented towards new acquisition and quantification techniques for in vivo proton, phosphorous, carbon, nitrogen MRS and fast MRSI, diffusion weighted spectroscopy and brain macromolecules quantification. She is now applying these developments on chronic hepatic encephalopathy, a research area that she developed at CIBM (https://actu.epfl.ch/news/when-liver-disease-affects-the-brain/), and on different collaborative projects with researchers from the five partner institutions of CIBM. Education PhD | RMN Laboratory MIB 2003 – 2006 University Claude-Bernard Lyon 1, France Master of Science | Biophysics and Medical Physics 2002 – 2003 University Babes-Bolyai, Cluj Napoca, Romania Professionals experiences Head 2025–2025 CIBM PCI EPFLMER 2024–2024 EPFL, School of Basic Sciences Deputy 2023–2023 EPFL, CIBM MRI EPFL AITResearch and Teaching Associate 2022–2024 EPFL, School of Basic SciencesSenior Research Staff Scientist and 9.4T MRI Operational Manager 2012–2025 EPFL, CIBM MRI EPFL AITPostdoctoral researcher 2007–2012 EPFL, CIBM MRI EPFL AIT ResearchGrants 2022-2026 - PI in the Swiss National Science Foundation, n° 205321L_207935, "Developments of innovative fast acquisition and metabolic modelling strategies for clinical and preclinical deuterium MR imaging in the brain at ultra-high field", Co-PI: B Lanz (CIBM) B Strasser (University of Vienna)2022 - PI in the Swiss National Science Foundation, n° 213184, "The International Magnetic Resonance Spectroscopy Workshop «MRS 2022: Overcoming the Barriers to Clinical Use»", Co-PI: B Alves, A Klauser, R Kreis, H Lajous, B Lanz, J Mosso, K Pierzchala, D Simicic, D Van de Ville, D Wenz, L Xin2021-2025 - PI in the Swiss National Science Foundation, n° 310030_201218 "Enhanced MR Spectroscopic mapping of brain regional changes in type C hepatic encephalopathy of juvenile rats to develop novel combinatorial treatments," Co-PI: O Braissant (CHUV) V McLin (HUG)2019-2021 - Co-applicant in the Innosuisse - Suisse Innovation Agency application "Pearl injectable implants, a solution for the reconstruction of ultra-large volumes of soft tissues post-injury"2018-2022 - Vice-coordinator in the H2020-MSCA-ITN-2018 application " INtegrating Magnetic Resonance SPectroscopy and Multimodal Imaging for Research and Education in MEDicine" (INSPiRE-MED, 813120)2017-2021: Swiss National Science Foundation; grant n° 31003A-175778/1 to Braissant&Cudalbu. «Cerebral creatine deficiency syndromes: New in vivo AAV approaches to treat SLC6A8 deficiency.»2017-2021: Swiss National Science Foundation; grant n° 310030_173222/1 to Cudalbu&Braissant&McLin. «Translational Non-Invasive Metabolic Studies towards Novel Treatments of Chronic Hepatic Encephalopathy in Developing Brain, from 3D Organotypic Brain Cell Cultures to the In vivo Rat and Human Brain.»2017-2018: Co-applicant in the Swiss Cancer League application «Characterizing invasiveness of patient derived brain tumor transplants in mice by gene expression profiling in association with metabolite profiles obtained by magnetic resonance spectroscopy (MRS). A pilot project», (PI Monika Hegi)2014-2016: Co-applicant in the Swiss Bridge Foundation application "Towards patient-specific treatments in glioblastoma: Comparison and validation of high-resolution imaging and molecular profiles of human glioblastoma and respective paired orthotopic xenografts in the mouse" (PI Andreas Hottinger)2014: PI for the Industrial grant VSL Pharmaceuticals Inc.2013-2017: Co-applicant in FP7-PEOPLE Marie Curie Initial Training Network project "Transforming Magnetic Resonance Spectroscopy into a Clinical Tool" (TRANSACT) Teaching & PhD PhD Students Juliette Beaubis Past EPFL PhD Students as codirector Veronika Rackayová, Dunja Simicic, Jessie Mosso, Brayan Alves Courses CIBM translational MR neuroimaging & spectroscopy PHYS-770 Magnetic resonance imaging (MRI) and spectroscopy (MRS) will be addressed in detail, along with experimental design, data gathering and processing on MRS, structural and functional MRI in humans and rodents, and hands-on experience with MRI scanners. MRI Practicals on CIBM preclinical imaging systems PHYS-473 The goal of this course is to teach students how to perform basic MRI and MRS experiments in-vivo and ex-vivo directly on preclinical horizontal ultra-high field MRI systems.