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Rolf Gruetter

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Related publications (417)

Page 3 of 21

Proton and phosphorus magnetic resonance spectroscopy of a mouse model of Alzheimer's disease

Rolf Gruetter, Patrick Aebischer, Cristina Ramona Cudalbu Moldovan, Bernard Schneider, Hongxia Lei, Sharon Janssens, Lili Sun-Reimer

The development of new diagnostic criteria for Alzheimer's disease (AD) requires new in vivo markers reflecting early pathological changes in the brain of patients. Magnetic resonance (MR) spectroscopy has been shown to provide useful information about the ...

Ios Press2012

Radical-free hyperpolarized MRI using endogenously occurring pyruvate analogues and UV-induced nonpersistent radicals

Rolf Gruetter, Josefina Adriana Maria Bastiaansen, Hikari Ananda Infinity Yoshihara, Andrea Capozzi, Alice Radaelli, Claudia Christina Zanella

It was recently demonstrated that nonpersistent radicals can be generated in frozen solutions of metabolites such as pyruvate by irradiation with UV light, enabling radical-free dissolution dynamic nuclear polarization. Although pyruvate is endogenous, the ...

WILEY2021

Impact of hepatic lipid accumulation and composition on glucose tolerance and insulin sensitivity: a longitudinal study in male and female mice

Rolf Gruetter, Ana Francisca Leal Silva Soares, Hongxia Lei

Background and aims: Metabolic disruptions characterized by high hepatic lipid content (HLC) are associated with impairments in whole body glucose homeostasis. To gain insight on the role of hepatic lipids in the metabolic performance in the absence artifi ...

Springer2014

A comparison of in vivo (13) C MR brain glycogen quantification at 9.4 and 14.1 T

Rolf Gruetter, Yves Pilloud, Ruud van Heeswijk

The high molecular weight and low concentration of brain glycogen render its noninvasive quantification challenging. Therefore, the precision increase of the quantification by localized (13) C MR at 9.4 to 14.1 T was investigated. Signal-to-noise ratio inc ...

Wiley2012

Comparison of T-1 Relaxation Times of the Neurochemical Profile in Rat Brain at 9.4 Tesla and 14.1 Tesla

Rolf Gruetter, Cristina Ramona Cudalbu Moldovan, Lijing Xin

Knowledge of T-1 relaxation times can be important for accurate relative and absolute quantification of brain metabolites, for sensitivity optimizations, for characterizing molecular dynamics, and for studying changes induced by various pathological condit ...

Wiley-Blackwell2009

Longitudinal neurochemical modifications in the aging mouse brain measured in vivo by 1H magnetic resonance spectroscopy

João Miguel das Neves Duarte, Rolf Gruetter

Alterations to brain homeostasis during development are reflected in the neurochemical profile determined noninvasively by (1)H magnetic resonance spectroscopy. We determined longitudinal biochemical modifications in the cortex, hippocampus, and striatum o ...

Elsevier Science Inc2014

Impact of Caffeine Consumption on Type 2 Diabetes-Induced Spatial Memory Impairment and Neurochemical Alterations in the Hippocampus

Rolf Gruetter, João Miguel das Neves Duarte

Diabetes affects the morphology and plasticity of the hippocampus, and leads to learning and memory deficits. Caffeine has been proposed to prevent memory impairment upon multiple chronic disorders with neurological involvement. We tested whether long-term ...

2019

Proton T-2 relaxation time of J-coupled cerebral metabolites in rat brain at 9.4T

Rolf Gruetter, Lijing Xin, Giulio Gambarota

Knowledge of proton T-2 relaxation time of metabolites is essential for proper quantitation of metabolite concentrations in localized proton spectroscopy, especially at moderate to long TEs. Although the T-2 relaxation time of singlets, such as that of cre ...

Wiley-Blackwell2008

Social isolation stress and chronic glutathione deficiency have a common effect on the glutamine-to-glutamate ratio and myo-inositol concentration in the mouse frontal cortex

João Miguel das Neves Duarte, Rolf Gruetter, Alberto Corcoba

Environmental stress can interact with genetic predisposition to increase the risk of developing psychopathology. In this work, we tested the hypothesis that social isolation stress interacts with impaired glutathione synthesis and have cumulative effects ...

Wiley-Blackwell2017

Capturing the spatiotemporal dynamics of self-generated, task-initiated thoughts with EEG and fMRI

Rolf Gruetter, João Pedro Forjaco Jorge, Lucie Bréchet

The temporal structure of self-generated cognition is a key attribute to the formation of a meaningful stream of consciousness. When at rest, our mind wanders from thought to thought in distinct mental states. Despite the marked importance of ongoing menta ...

2019

Unedited in vivo detection and quantification of gamma-aminobutyric acid in the occipital cortex using short-TE MRS at 3 T

Rolf Gruetter

Short-TE MRS has been proposed recently as a method for the in vivo detection and quantification of gamma-aminobutyric acid (GABA) in the human brain at 3 T. In this study, we investigated the accuracy and reproducibility of short-TE MRS measurements of GA ...

Wiley-Blackwell2013

In vivo metabolic profiling of glioma-initiating cells using proton magnetic resonance spectroscopy at 14.1 Tesla

Rolf Gruetter, Cristina Ramona Cudalbu Moldovan

In the last decade, evidence has emerged indicating that the growth of a vast majority of tumors including gliomas is sustained by a subpopulation of cancer cells with stem cell properties called cancer initiating cells. These cells are able to initiate an ...

Wiley-Blackwell2012

The importance of priors for l2 regularization and total variation methods in quantitative susceptibility mapping

Rolf Gruetter, Yves Wiaux, José Pedro Rebelo Ferreira Marques, Gilles Puy, Diana Khabipova

Phase imaging has been demonstrated to offer a good contrast between and within brain tissues at 7T[1] with iron and myelin concentration being amongst the main modulators of the observed contrast due to their para- and dia-magnetic properties.Phase imagin ...

2012

Probiotics combined with rifaximin influence the neurometabolic changes in a rat model of type C HE

Rolf Gruetter, Cristina Ramona Cudalbu Moldovan, Katarzyna Pierzchala, Emmanuelle Ines Flatt

Type C hepatic encephalopathy (HE) is a neuropsychiatric disease caused by chronic liver disease. Management of type C HE remains an important challenge because treatment options are limited. Both the antibiotic rifaximin and probiotics have been reported ...

Nature Portfolio2021

Feasibility of direct mapping of cerebral fluorodeoxy-D-glucose metabolism in situ at subcellular resolution using soft X-ray fluorescence

Rolf Gruetter, Carole Poitry-Yamate, Mario Gaetano Lepore, Vincent Gajdosik

Glucose metabolism is difficult to image with cellular resolution in mammalian brain tissue, particularly with (18) fluorodeoxy-D-glucose (FDG) positron emission tomography (PET). To this end, we explored the potential of synchrotron-based low-energy X-ray ...

Wiley-Blackwell2013

Compartmentalized Cerebral Metabolism of [1,6-(13)C]Glucose Determined by in vivo (13)C NMR Spectroscopy at 14.1 T

João Miguel das Neves Duarte, Rolf Gruetter, Bernard Lanz

Cerebral metabolism is compartmentalized between neurons and glia. Although glial glycolysis is thought to largely sustain the energetic requirements of neurotransmission while oxidative metabolism takes place mainly in neurons, this hypothesis is matter o ...

Frontiers Research Foundation2011

Detection of neuronal activity and metabolism in a model of dehydration-induced anorexia in rats at 14.1T using manganese-enhanced MRI and 1H MRS

Rolf Gruetter, Nathalie Just

In this study, hypothalamic activation was performed by dehydration-induced anorexia (DIA) and overnight food suppression (OFS) in female rats. The assessment of the hypothalamic response to these challenges by manganese-enhanced MRI showed increased neuro ...

Wiley-Blackwell2011

Towards high-quality simultaneous EEG-fMRI at 7T: Detection and reduction of EEG artifacts due to head motion

Rolf Gruetter, Wietske Van der Zwaag, João Pedro Forjaco Jorge, Patricia Figueiredo

The enhanced functional sensitivity offered by ultra-high field imaging may significantly benefit simultaneous EEG-fMRI studies, but the concurrent increases in artifact contamination can strongly compromise EEG data quality. In the present study, we focus ...

Elsevier2015

Prospective and retrospective motion correction in diffusion magnetic resonance imaging of the human brain

Rolf Gruetter, Tobias Kober, Gunnar Krüger

Diffusion-weighting in magnetic resonance imaging (MRI) increases the sensitivity to molecular Brownian motion, providing insight in the micro-environment of the underlying tissue types and structures. At the same time, the diffusion weighting renders the ...

Elsevier2012

An improved trap design for decoupling multinuclear RF coils

Rolf Gruetter, Eulalia Serés Roig

Purpose Multinuclear magnetic resonance spectroscopy and imaging require a radiofrequency probe capable of transmitting and receiving at the proton and non-proton frequencies. To minimize coupling between probe elements tuned to different frequencies, LC ( ...

Wiley-Blackwell2014