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Rolf Gruetter

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Related publications (417)

Page 2 of 21

Hepatic glucose sensing is required to preserve β cell glucose competence

Rolf Gruetter, Bernard Lanz, Carole Poitry-Yamate, Frédéric Schütz

Liver glucose metabolism plays a central role in glucose homeostasis and may also regulate feeding and energy expenditure. Here we assessed the impact of glucose transporter 2 (Glut2) gene inactivation in adult mouse liver (LG2KO mice). Loss of Glut2 suppr ...

Amer Soc Clinical Investigation Inc2013

Longitudinal MR Assessment of Hypoxic Ischemic Injury in the Immature Rat Brain

Rolf Gruetter, Yohan Van de Looij

Extremely preterm infants commonly show brain injury with long-term structural and functional consequences. Three-day-old (P3) rat pups share some similarities in terms of cerebral development with the very preterm infant (born at 24-28 weeks of gestation) ...

Wiley-Blackwell2011

Evolution of the neurochemical profile after transient focal cerebral ischemia in the mouse brain

Rolf Gruetter, Hongxia Lei

Evolution of the neurochemical profile consisting of 19 metabolites after 30 mins of middle cerebral artery occlusion was longitudinally assessed at 3, 8 and 24 h in 6 to 8 mu L volumes in the striatum using localized H-1-magnetic resonance spectroscopy at ...

Nature Publishing Group2009

Multi-modal assessment of long-term erythropoietin treatment after neonatal hypoxic-ischemic injury in rat brain

Rolf Gruetter, Yohan Van de Looij

Erythropoietin (EPO) has been recognized as a neuroprotective agent. In animal models of neonatal brain injury, exogenous EPO has been shown to reduce lesion size, improve structure and function. Experimental studies have focused on short course treatment ...

Public Library of Science2014

Developmental and metabolic brain alterations in rats exposed to bisphenol A during gestation and lactation

Rolf Gruetter, Nicolas Kunz

In recent years, considerable research has focused on the biological effect of endocrine-disrupting chemicals. Bisphenol A (BPA) has been implicated as an endocrine-disrupting chemical (EDC) due to its ability to mimic the action of endogenous estrogenic h ...

Elsevier2011

Energy metabolism in the rat cortex under thiopental anaesthesia measured

João Miguel das Neves Duarte, Rolf Gruetter, Nathalie Just, Sarah Catherine Sonnay

Barbiturates, commonly used as general anaesthetics, depress neuronal activity and thus cerebral metabolism. Moreover, they are likely to disrupt the metabolic support of astrocytes to neurons, as well as the uptake of nutrients from circulation. By employ ...

Wiley-Blackwell2017

Impact of aerobic exercise type on blood flow, muscle energy metabolism, and mitochondrial biogenesis in experimental lower extremity artery disease

Rolf Gruetter, Carole Poitry-Yamate

Exercise training (ET) is recommended for lower extremity artery disease (LEAD) management. However, there is still little information on the hemodynamic and metabolic adaptations by skeletal muscle with ET. We examined whether hindlimb perfusion/vasculari ...

Nature Research2020

Hierarchical status predicts behavioral vulnerability and nucleus accumbens metabolic profile following chronic social defeat stress

Rolf Gruetter, Maria del Carmen Sandi Perez, Hongxia Lei, João Pedro de Matos Rodrigues, Antoine Timothée Cherix, Thomas Didier Larrieu

Extensive data highlight the existence of major differences in individuals’ susceptibility to stress [1; 2; 3 ; 4]. While genetic factors [5 ; 6] and exposure to early life stress [7 ; 8] are key components for such neurobehavioral diversity, intriguing ob ...

2017

PIRACY: An Optimized Pipeline for Functional Connectivity Analysis in the Rat Brain

Rolf Gruetter, Ileana Ozana Jelescu, Ting Yin, Yujian Diao

Resting state functional MRI (rs-fMRI) is a widespread and powerful tool for investigating functional connectivity (FC) and brain disorders. However, FC analysis can be seriously affected by random and structured noise from non-neural sources, such as phys ...

2021

Prospective head motion correction using FID-guided on-demand image navigators

Rolf Gruetter, Reto Meuli, Tobias Kober, Gunnar Krüger, Tom Hilbert, Bénédicte Marie Maréchal, Guillaume Bonnier, Maryna Volodimirivna Waszak, Pavel Falkovskiy

PURPOSE: We suggest a motion correction concept that employs free-induction-decay (FID) navigator signals to continuously monitor motion and to guide the acquisition of image navigators for prospective motion correction following motion detection. METHODS: ...

Wiley-Blackwell2017

Selective Resonance Suppression H-1-[C-13] NMR Spectroscopy With Asymmetric Adiabatic RF Pulses

Rolf Gruetter, Lijing Xin, Hanne Frenkel

Despite obvious improvements in spectral resolution at high magnetic field, the detection of C-13 labeling by H-1-[C-13] NMR spectroscopy remains hampered by spectral overlap, such as in the spectral region of H-1 resonances bound to C3 of glutamate (Glu) ...

Wiley-Blackwell2009

In vivo assessment of myelination by phase imaging at high magnetic field

Rolf Gruetter, José Pedro Rebelo Ferreira Marques, Rajika Maddage

The present study evaluated the potential of using the phase of T-2* weighted MR images to characterize myelination during brain development and pathology in rodents at 9.4 T. Phase contrast correlated with myelin content assessed by histology and suggests ...

Elsevier2012

MR Spectroscopy of the Human Brain With Enhanced Signal Intensity at Ultrashort Echo Times on a Clinical Platform at 3T and 7T

Rolf Gruetter, Gunnar Krüger, Giulio Gambarota

Recently, the spin-echo full-intensity acquired localized (SPECIAL) spectroscopy technique was proposed to unite the advantages of short TEs on the order of milliseconds (ms) with full sensitivity and applied to in vivo rat brain. In the present study, SPE ...

Wiley-Blackwell2009

In vivo detection of d-amino acid oxidase with hyperpolarized d-[1-C-13]alanine

Rolf Gruetter, Hikari Ananda Infinity Yoshihara, Alice Radaelli

d-amino acid oxidase (DAO) is a peroxisomal enzyme that catalyzes the oxidative deamination of several neutral and basic d-amino acids to their corresponding alpha-keto acids. In most mammalian species studied, high DAO activity is found in the kidney, liv ...

2020

B(0)shimming for in vivo magnetic resonance spectroscopy: Experts' consensus recommendations

Rolf Gruetter, Cristina Ramona Cudalbu Moldovan

Magnetic resonance spectroscopy (MRS) and spectroscopic imaging (MRSI) allow the chemical analysis of physiological processes in vivo and provide powerful tools in the life sciences and for clinical diagnostics. Excellent homogeneity of the static B(0)magn ...

2020

Brain energy metabolism measured by 13C magnetic resonance spectroscopy in vivo upon infusion of [3-13C]lactate

João Miguel das Neves Duarte, Rolf Gruetter

The brain uses lactate produced by glycolysis as an energy source. How lactate originated from the blood stream is used to fuel brain metabolism is not clear. The current study measures brain metabolic fluxes and estimates the amount of pyruvate that becom ...

Wiley-Blackwell2015

Protective effects of maternal nutritional supplementation with lactoferrin on growth and brain metabolism

Rolf Gruetter, Yohan Van de Looij

Background:Intrauterine growth restriction (IUGR) is a major risk factor for both perinatal and long-term morbidity. Bovine lactoferrin (bLf) is a major milk glycoprotein considered as a pleiotropic functional nutrient. The impact of maternal supplementati ...

Nature Publishing Group2014

Metabolic and perfusion responses to acute hypoglycemia in the rat cortex: A non-invasive magnetic resonance approach

Rolf Gruetter, Hongxia Lei

Hypoglycemia is critical condition during diabetic treatment that involves intensive insulin therapy, and it may impair brain function. We aimed to compare cortical responses of three hypoglycemic phases and the restoration of glycemia to control levels af ...

Wiley-Blackwell2020

Direct in vivo measurement of glycine and the neurochemical profile in the rat medulla oblongata

Rolf Gruetter, Lijing Xin, João Miguel das Neves Duarte, Giulio Gambarota

The medulla oblongata (MO) contains a high density of glycinergic synapses and a particularly high concentration of glycine The aims of this study were to measure directly in vivo the neurochemical profile, including glycine, in MO using a spin-echo-based ...

Wiley-Blackwell2010

Investigation of field and diffusion time dependence of the diffusion-weighted signal at ultrahigh magnetic fields

Rolf Gruetter, Yohan Van de Looij, Nicolas Kunz

Over the last decade, there has been a significant increase in the number of high-magnetic-field MRI magnets. However, the exact effect of a high magnetic field strength (B0 ) on diffusion-weighted MR signals is not yet fully understood. The goal of this s ...

Wiley-Blackwell2013