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Rolf Gruetter

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Related publications (417)

Page 4 of 21

Astrocytic and neuronal oxidative metabolism are coupled to the rate of glutamate-glutamine cycle in the tree shrew visual cortex

João Miguel das Neves Duarte, Rolf Gruetter, Nathalie Just, Sarah Catherine Sonnay

Astrocytes play an important role in glutamatergic neurotransmission, namely by clearing synaptic glutamate and converting it into glutamine that is transferred back to neurons. The rate of this glutamate–glutamine cycle (VNT) has been proposed to couple t ...

Wiley-Blackwell2018

Snapshot gradient-recalled echo-planar images of rat brains at long echo time at 9.4 T

Rolf Gruetter, Hongxia Lei, Nathalie Just

With improved B-0 homogeneity along with satisfactory gradient performance at high magnetic fields, snapshot gradient-recalled echo-planar imaging (GRE-EPI) would perform at long echo times (TEs) oil the order of T-2*, which intrinsically allows obtaining ...

Elsevier2008

Spread spectrum for compressed sensing techniques in magnetic resonance imaging

Jean-Philippe Thiran, Rolf Gruetter, Dimitri Nestor Alice Van De Ville, Pierre Vandergheynst, Yves Wiaux, Gilles Puy

Magnetic resonance imaging (MRI) probes signals through Fourier measurements. Accelerating the acquisition process is of major interest for various MRI applications. The recent theory of compressed sensing shows that sparse or compressible signals may be r ...

IEEE Signal Process. Soc.2010

Contribution of macromolecules to brain H-1 MR spectra: Experts' consensus recommendations

Rolf Gruetter, Cristina Ramona Cudalbu Moldovan, Lijing Xin, Hongxia Lei, Dunja Simicic, Veronika Rackayová

Proton MR spectra of the brain, especially those measured at short and intermediate echo times, contain signals from mobile macromolecules (MM). A description of the main MM is provided in this consensus paper. These broad peaks of MM underlie the narrower ...

WILEY2020

Clinical Proton MR Spectroscopy in Central Nervous System Disorders

Rolf Gruetter, Cristina Ramona Cudalbu Moldovan

A large body of published work shows that proton (hydrogen 1 [(1)H]) magnetic resonance (MR) spectroscopy has evolved from a research tool into a clinical neuroimaging modality. Herein, the authors present a summary of brain disorders in which MR spectrosc ...

2014

Steady-state brain glucose transport kinetics re-evaluated with a four-state conformational model

João Miguel das Neves Duarte, Rolf Gruetter, Hongxia Lei, Carole Poitry-Yamate

Glucose supply from blood to brain occurs through facilitative transporter proteins. A near linear relation between brain and plasma glucose has been experimentally determined and described by a reversible model of enzyme kinetics. A conformational four-st ...

Frontiers Research Foundation2009

Assessment of metabolic fluxes in the mouse brain in vivo using (1)H-[(13)C] NMR spectroscopy at 14.1 Tesla

Rolf Gruetter, Lijing Xin, Hongxia Lei, Bernard Lanz

(13)C magnetic resonance spectroscopy (MRS) combined with the administration of (13)C labeled substrates uniquely allows to measure metabolic fluxes in vivo in the brain of humans and rats. The extension to mouse models may provide exclusive prospect for t ...

Nature Publishing Group2015

BOLD responses to trigeminal nerve stimulation

Rolf Gruetter, Carl Petersen, Nathalie Just

The current study investigates a new model of barrel cortex activation using stimulation of the infraorbital branch of the trigeminal nerve. A robust and reproducible activation of the rat barrel cortex was obtained following trigeminal nerve stimulation. ...

2010

Technical and experimental features of Magnetic Resonance Spectroscopy of brain glycogen metabolism

Rolf Gruetter, Ana Francisca Leal Silva Soares, Hongxia Lei

In the brain, glycogen is a source of glucose not only in emergency situations but also during normal brain activity. Altered brain glycogen metabolism is associated with energetic dysregulation in pathological conditions, such as diabetes or epilepsy. Bot ...

Elsevier2017

Glutathione deficit impairs myelin maturation: relevance for white matter integrity in schizophrenia patients

Jean-Philippe Thiran, Rolf Gruetter, Patric Hagmann, Lijing Xin, Alessandra Griffa, Philipp Baumann

Schizophrenia pathophysiology implies both abnormal redox control and dysconnectivity of the prefrontal cortex, partly related to oligodendrocyte and myelin impairments. As oligodendrocytes are highly vulnerable to altered redox state, we investigated the ...

Nature Publishing Group2015

An in vivo ultrahigh field 14.1 T (1) H-MRS study on 6-OHDA and α-synuclein-based rat models of Parkinson's disease: GABA as an early disease marker

Rolf Gruetter, Patrick Aebischer, Bernard Schneider, Mélanie Craveiro, Philippe Guillaume Coune, Meret Gaugler

The detection of Parkinson's disease (PD) in its preclinical stages prior to outright neurodegeneration is essential to the development of neuroprotective therapies and could reduce the number of misdiagnosed patients. However, early diagnosis is currently ...

Wiley-Blackwell2013

Editing through multiple bonds: Threonine detection

Rolf Gruetter

In in vivo H-1 spectroscopy, the signal at 1.32 ppm is usually assigned to lactate. This resonance position is shared with threonine at physiological pH. The similarity of spectral patterns of lactate and threonine renders the separate measurement of eithe ...

Wiley-Blackwell2008

MP2RAGE multiple sclerosis magnetic resonance imaging at 3 T

Rolf Gruetter, Reto Meuli, Tobias Kober, Cristina Granziera, Gunnar Krüger, Delphine Ribes Lemay

Objectives: Lesion detection and characterization in multiple sclerosis (MS) are an essential part of its clinical diagnosis and an important research field. In this pilot study, we applied the recently introduced two inversion-contrast magnetization-prepa ...

2012

Nucleus accumbens neurochemistry in human anxiety: A 7 T 1H-MRS study

Rolf Gruetter, Maria del Carmen Sandi Perez, Lijing Xin, Alina Veronika Irene Strasser

Individual differences in anxiety provide a differential predisposition to develop neuropsychiatric disorders. The neurochemical underpinnings of anxiety remain elusive, particularly in deep structures, such as the nucleus accumbens (NAc) whose involvement ...

2019

MRS glucose mapping and PET joining forces: Re-evaluation of the lumped constant in the rat brain under isoflurane anaesthesia

João Miguel das Neves Duarte, Rolf Gruetter, Hongxia Lei, Malte Alf

Although numerous positron emission tomography (PET) studies with ((8) F-fluoro-deoxyglucose) FDG have reported quantitative results on cerebral glucose kinetics and consumption, there is a large variation between the absolute values found in the literatur ...

Wiley-Blackwell2014

Parallel imaging with phase scrambling

Rolf Gruetter, Daniel Gallichan

PURPOSE: Most existing methods for accelerated parallel imaging in MRI require additional data, which are used to derive information about the sensitivity profile of each radiofrequency (RF) channel. In this work, a method is presented to avoid the acquisi ...

Wiley-Blackwell2015

Diffusion-Weighted Spectroscopy: A Novel Approach to Determine Macromolecule Resonances in Short-Echo Time H-1-MRS

Rolf Gruetter, Cristina Ramona Cudalbu Moldovan, Nicolas Kunz

Quantification of short-echo time proton magnetic resonance spectroscopy results in >18 metabolite concentrations (neurochemical profile). Their quantification accuracy depends on the assessment of the contribution of macromolecule (MM) resonances, previou ...

Wiley-Blackwell2010

Design and performance of a DNP prepolarizer coupled to a rodent MRI scanner

Rolf Gruetter, Arnaud Comment, Sami Jannin, Jacques Van Der Klink

For most of the last forty years, the techniques of Dynamic Nuclear Polarization (DNP) have been confined to particle-physics laboratories building polarized targets, but recently it has been shown that samples similar to a solid target can be transformed ...

2007

Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendations

Rolf Gruetter, Cristina Ramona Cudalbu Moldovan, Lijing Xin, Bernard Lanz

In vivo MRS is a non-invasive measurement technique used not only in humans, but also in animal models using high-field magnets. MRS enables the measurement of metabolite concentrations as well as metabolic rates and their modifications in healthy animals ...

WILEY2020

Deletion of Crtc1 leads to hippocampal neuroenergetic impairments associated with depressive-like behavior

Rolf Gruetter, Maria del Carmen Sandi Perez, Bernard Lanz, Carole Poitry-Yamate, Antoine Timothée Cherix, Olivia Zanoletti, Jocelin Grosse

Mood disorders (MD) are a major burden on society as their biology remains poorly understood, challenging both diagnosis and therapy. Among many observed biological dysfunctions, homeostatic dysregulation, such as metabolic syndrome (MeS), shows considerab ...

SPRINGERNATURE2022