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Harm-Anton Klok

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Related publications (195)

Copolymerization of 2,2,3,3,4,4,4-heptafluorobutyl acrylate with butyl acrylate via RAFT polymerization

Copolymers of fluoroacrylates have interesting properties like excellent resistance to chemicals, oils and fuels, high thermal stability and high hydrophobicity. This investigation reports the copolymerization of 2,2,3,3,4,4,4-heptafluorobutyl acrylate (HF ...

Elsevier2014

Poly[N-(2-hydroxypropyl)methacrylamide] nanogels by RAFT polymerization in inverse emulsion

Harm-Anton Klok, Harald Wutzel, Felix Richter

Inverse emulsion reversible addition-fragmentation chain transfer (RAFT) polymerization has been used to generate N-(2-hydroxypropyl)methacrylamide (HPMA) based nanoparticles and reduction-sensitive nanogels with diameters of 100-200 nm. Inverse emulsion R ...

Royal Society of Chemistry2014

Controlled release from a mechanically-stimulated thermosensitive self-heating composite hydrogel

Dominique Pioletti, Harm-Anton Klok, Mohamadreza Nassajian Moghadam, Vitaliy Kolesov

Temperature has been extensively explored as a trigger to control the delivery of a payload from environment-sensitive polymers. The need for an external heat source only allows limited spatiotem- poral control over the delivery process. We propose a new a ...

Elsevier Sci Ltd2014

DNA delivery with hyperbranched polylysine: A comparative study with linear and dendritic polylysine

Florian Maria Wurm, Lucia Baldi Unser, David Hacker, Harm-Anton Klok, Zuzana Kadlecova, Yashas Rajendra

PEI and polylysine are among the most investigated synthetic polymeric carriers for DNA delivery. Apart from their practical use, these 2 classes of polymers are also of interest from a fundamental point of view as they both can be prepared in different ar ...

Elsevier2013

Standing on the shoulders of hermann staudinger: Post-polymerization modification from past to present

Harm-Anton Klok

With a span as long as the history of polymer science itself, post-polymerization modification represents a versatile platform for the preparation of diversely functionalized polymers from a single precursor. Starting with the initial efforts by Staudinger ...

Wiley-Blackwell2013

One-pot squaric acid diester mediated aqueous protein conjugation

Harm-Anton Klok, Frederik Roman Wurm

A water-soluble squaric acid dialkyl diester derivative is presented, which enables one-pot, two-step amine-selective protein conjugation reactions with (functional) amines in water. This reagent not only allows all-aqueous protein modifications, but also ...

Royal Society of Chemistry2013

Dual and multi-stimuli responsive polymeric nanoparticles for programmed site-specific drug delivery

Harm-Anton Klok

In the past decades, polymeric nanoparticles have emerged as a most promising and viable technology platform for targeted and controlled drug delivery. As vehicles, ideal nanoparticles are obliged to possess high drug loading levels, deliver drug to the sp ...

Elsevier Sci Ltd2013

Combating HIV infection with peptide: Polymer conjugates

Harm-Anton Klok

Amer Chemical Soc2013

Multifaceted polymer coated, gold nanoparticles

Harm-Anton Klok, Li Chen

Gold nanoparticles modified with a two (or multi-) component polymer brush coating are an exciting class of nanomaterials. The presentation of two (or more) different polymer components can lead to truly multifaceted nanoparticles that can incorporate mult ...

Royal Soc Chemistry2013

Functional Polymers by Post-Polymerization Modification: Concepts, Guidelines, and Applications

Harm-Anton Klok

In modern polymer science a variety of polymerization methods for the direct synthesis of polymers bearing functional groups are known. However, there is still a large number of functional groups that may either completely prevent polymerization or lead to ...

wiley2013

Polymers, Colloids, and Interfaces

Harm-Anton Klok

Swiss Chemical Soc2013

DNA delivery with hyperbranched polylysine

Harm-Anton Klok

Amer Chemical Soc2013

Be squared: expanding the horizon of squaric acid-mediated conjugations

Harm-Anton Klok, Frederik Roman Wurm

Squaric acid diesters can be applied as reagents to couple two amino-functional compounds. Consecutive coupling of two amines allows the synthesis of asymmetric squaric acid bisamides with either low molecular weight compounds but also biomolecules or poly ...

Royal Society of Chemistry2013

Postpolymerization Modification of Poly(glycidyl methacrylate) Brushes: An XPS Depth-Profiling Study

Raphaël Barbey, Harm-Anton Klok, Vincent Laporte

Surface-initiated polymerization represents a versatile strategy to modify a diverse range of materials with thin, functional polymer coatings. While in many cases the desired functional groups can be directly incorporated via (co)polymerization of the app ...

American Chemical Society2013

Aqueous Fabrication of pH-Gated, Polymer-Brush-Modified Alumina Hybrid Membranes

Harm-Anton Klok, Caroline Sugnaux

In this Article, we studied the surface immobilization of five organic-acid-modified atom-transfer radical polymerization (ATRP) initiators based on salicylic acid, catechol, phthalic acid, and m- and p-benzoic add on alumina, and we also investigated the ...

Amer Chemical Soc2013

Comparative Study on the In Vitro Cytotoxicity of Linear, Dendritic, and Hyperbranched Polylysine Analogues

Florian Maria Wurm, Lucia Baldi Unser, David Hacker, Harm-Anton Klok, Zuzana Kadlecova

Lysine-based polycations are widely used as nonviral carriers for gene delivery. This manuscript reports the results of a comparative study on the in vitro cytotoxicity of a library of three structural polylysine variants, namely, linear polylysine (LPL), ...

American Chemical Society2012

Synthesis and post-polymerization modification of poly(pentafluorophenyl methacrylate) brushes

Harm-Anton Klok

Post-polymerization modification is a powerful strategy to endow polymers with functional groups that cannot be incorporated via direct polymerization. This manuscript explores the reversible addition-fragmentation chain transfer polymerization (RAFT) of p ...

2012

Hyperbranched Polylysine: A Versatile, Biodegradable Transfection Agent for the Production of Recombinant Proteins by Transient Gene Expression and the Transfection of Primary Cells

Florian Maria Wurm, Lucia Baldi Unser, David Hacker, Harm-Anton Klok, Zuzana Kadlecova, Yashas Rajendra

The feasibility of a new transfection agent, HBPL, for the production of recombinant IgG antibody via TGE as well as for the transfection of primary cells is studied. Under the conditions investigated, transfection of CHO-DG44 cells using HBPL results in I ...

2012

Site-Specific PEGylation of HR2 Peptides: Effects of PEG Conjugation Position and Chain Length on HIV-1 Membrane Fusion Inhibition and Proteolytic Degradation

Harm-Anton Klok, Maarten Danial

Peptides derived from the HR1 or HR2 regions of the HIV-1 envelope glycoprotein gp41 have been shown to be effective inhibitors to prevent virus-host cell membrane fusion. These peptide drugs, however, suffer from relatively short plasma half-lives and are ...

Amer Chemical Soc2012

Squaric Acid Mediated Chemoselective PEGylation of Proteins: Reactivity of Single-Step-Activated alpha-Amino Poly(ethylene glycol)s

Harm-Anton Klok, Frederik Roman Wurm

The covalent attachment of poly(ethylene glycol) (PEG) to therapeutically active proteins (PEGylation) has become an important method to deal with the pharmacological difficulties of these polypeptides, such as short body-residence times and immunogenicity ...

Wiley-V C H Verlag Gmbh2012

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