Publications de Harm-Anton Klok

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The pH-induced swelling and collapse of surface-tethered, weak polyelectrolyte brushes is of interest for the development of actuators or to allow pH controlled transport or adsorption. This contribution discusses results of an extensive series of quartz c ...

Cells are attractive as carriers that can help to enhance control over the biodistribution of polymer nanomedicines. One strategy to use cells as carriers is based on the cell surface immobilization of the nanoparticle cargo. While a range of strategies ca ...

Hydrophilic polymer brushes grown via surface-initiated ATRP from silicon oxide surfaces are susceptible to detachment via hydrolytic cleavage of the anchoring siloxane bond. This paper investigates the influence of the structure of the ATRP initiator on t ...

This contribution describes the preparation of nonfouling polypeptide brushes via surface-initiated ring-opening polymerization of oligo(ethylene glycol) modified L-lysine N-carboxyanhydrides. Circular dichroism experiments indicated that these surface-anc ...

Developing molecules that emulate the properties of naturally occurring ice-binding proteins (IBPs) is a daunting challenge. Rather than relying on the (limited) existing structure–property relationships that have been established for IBPs, here we report ...

It is well known that specific types of counterions affect the hydration of polyelectrolytes both in the bulk and at interfaces, but the mechanisms of this effect have not yet been fully understood. In this work, we have designed a model system, consisting ...

This article explores the feasibility of poly(pentafluorophenyl methacrylate) (PPFMA) prepared by reversible addition fragmentation chain transfer (RAFT) polymerization as a platform for the preparation of diverse libraries of functional polymers via postp ...

The current use of fertilizers is inefficient and not sustainable. The majority of the fertilizer applied does not reach the targeted crop but is lost in the water bodies and into the atmosphere, with harmful impact on the environment. To enhance the effic ...

A library of polymer-coated gold nanoparticles (AuNPs) differing in size and surface modifications was examined for uptake and induction of cellular stress responses in the endoplasmic reticulum (ER stress) in human brain endothelial cells (hCMEC/D3). ER s ...

Surface-initiated polymerizations represent a versatile toolbox to generate densely grafted assemblies of chain end-tethered polymers. At sufficiently short interchain distances, surface-grafted polymers are forced into an extended chain conformation, whic ...

A new strategy for the prepn. of protein-functionalized polymer brushes is reported, which is based on a combination of surface-initiated atom transfer radical polymn. (ATRP), p-nitrophenyl chloroformate activation of the surface hydroxyl groups, and subse ...

Chain-end-labeled polymers are interesting for a range of applications. In polymer nanomedicine, chain-end-labeled polymers are useful to study and help understand cellular internalization and intracellular trafficking processes. The recent advent of fluor ...

Delivery of therapeutics to the central nervous system (CNS) is challenging due to the presence of the blood-brain barrier (BBB). Amongst various approaches that have been explored to facilitate drug delivery to the CNS, the use of cells that have the intr ...

Surface-initiated polymerization reactions are a powerful tool to generate chain-end-tethered polymer brushes. This report presents a synthetic strategy that gives access to structurally well-defined hydrocarbon polymer brushes of controlled molecular weig ...

Anion-exchange-membrane fuel cells (AEMFCs) are a cost-effective alternative to proton-exchange-membrane fuel cells (PEMFCs). The development of high-performance and durable AEMFCs requires highly conductive and robust anion-exchange membranes (AEMs). Howe ...

The scope of this review is to highlight the application of polymer therapeutics in an effort to curb the transmission and infection of the human immunodeficiency virus (HIV). Following a description of the HIV life cycle, the use of approved antiretrovira ...

Anion-exchange membrane fuel cells (AEMFCs) are a promising, next-generation fuel cell technology. AEMFCs require highly conductive and robust anion-exchange membranes (AEMs), which are challenging to develop due to the tradeoff between conductivity and wa ...

(Figure Presented) Post-polymerization modification is based on the direct polymerization or copolymerization of monomers bearing chemoselective handles that are inert towards the polymerization conditions but can be quantitatively converted in a subsequen ...

This paper describes the synthesis of supramolecular polymer brushes via surface-initiated polymerization from adamantane-functionalized initiators that are noncovalently bound to beta-cyclodextrin- or cucurbit[7]uril-modified substrates. Surface-initiated ...

This manuscript reports a facile strategy for the modification of polyethylene, a widely used biomaterial, with a thin non-biofouling coating that can act as a platform to introduce biochemical cues to control and direct, e.g., cell adhesion and proliferat ...

Harm-Anton Klok

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Tuning the pH Sensitivity of Poly(methacrylic acid) Brushes

Covalent and Noncovalent Conjugation of Degradable Polymer Nanoparticles to T Lymphocytes

Improving the Stability in Aqueous Media of Polymer Brushes Grafted from Silicon Oxide Substrates by Surface-Initiated Atom Transfer Radical Polymerization

Nonfouling Polypeptide Brushes via Surface-initiated Polymerization of N-epsilon-oligo(ethylene glycol)succinate-L-lysine N-carboxyanhydride

A minimalistic cyclic ice-binding peptide from phage display

Specific Counterion Effects on the Swelling Behavior of Strong Polyelectrolyte Brushes

Postpolymerization modification of poly(pentafluorophenyl methacrylate): Synthesis of a diverse water-soluble polymer library

Biodegradable Polymers for Plant Nutrient Delivery and Recovery

Impact of polymer-modified gold nanoparticles on brain endothelial cells: exclusion of endoplasmic reticulum stress as a potential risk factor

Expanding the Polymer Mechanochemistry Toolbox through Surface-Initiated Polymerization

Protein-Functionalized Polymer Brushes

Synthesis and Postpolymerization Modification of Fluorine-End-Labeled Poly(Pentafluorophenyl Methacrylate) Obtained via RAFT Polymerization

T Cell-Mediated Transport of Polymer Nanoparticles across the Blood-Brain Barrier

Polymethylene Brushes via Surface-Initiated C1 Polyhomologation

Fluorinated Poly(aryl piperidinium) Membranes for Anion Exchange Membrane Fuel Cells

Polymeric Anti-HIV Therapeutics

Branched Poly(Aryl Piperidinium) Membranes for Anion-Exchange Membrane Fuel Cells

Synthesis of functional polymers by post-polymerization modification

Supramolecular Polymer Brushes Grafted via Atom Transfer Radical Polymerization from Surfaces Presenting Non-covalent, Host-Guest Complex-Based Initiators

A facile strategy for the modification of polyethylene substrates with non-fouling, bioactive poly(poly(ethylene glycol) methacrylate) brushes