Publication

Protein-Functionalized Polymer Brushes

Harm-Anton Klok, Kai Johnsson, Stefano Tugulu, Anke Arnold
2005
Journal Articles

Abstract

A new strategy for the prepn. of protein-functionalized polymer brushes is reported, which is based on a combination of surface-initiated atom transfer radical polymn. (ATRP), p-nitrophenyl chloroformate activation of the surface hydroxyl groups, and subsequent O6-benzylguanine (BG) functionalization. The BG-functionalized brushes are used to chemoselectively immobilize O6-alkylguanine-DNA-alkyltransferase (AGT) fusion proteins with a defined orientation and surface d. These protein-modified polymer brushes are attractive candidates for the development of protein microarrays. [on SciFinder (R)]

Official source

https://infoscience.epfl.ch/entities/publication/d0b6cebb-fb8d-4ab8-9a16-8ad950fe93a9

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Protein-Functionalized Polymer Brushes

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