Publications by Harm-Anton Klok

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Amino acid-based poly(ester urea)s are an attractive class of polymers that are of interest for a variety of biomedical applications. Generally, amino acid-based poly(ester urea)s are prepared by polymerization of diamines, which are obtained from the corr ...

Cellulose nanocrystals (CNCs) with different charge densities were utilized to examine the role of electrostatic interactions on surface-initiated atom transfer radical polymerization (SI-ATRP) in aqueous media. To this end, growth of hydrophilic uncharged ...

This contribution presents a new strategy to grow nonfouling poly (poly(ethylene glycol) methacrylate) (PPEGMA) brushes from polydimethylsiloxane (PDMS) substrates. The strategy presented here is based on the use of a sequence of vapor deposition/hydrolysi ...

Polymer brushes have been theoretically described, their behavior under diverse conditions has been modeled, and their preparation via surface-initiated polymerizations (SIPs) has been progressively refined. However, despite three decades of research endea ...

Piezo- and pyroelectric materials are of interest, for example, for energy harvesting applications, for the development of tactile sensors, as well as neuromorphic computing. This study reports the observation of pyro- and piezoelectricity in thin surface- ...

This report explores the use of sacrificial thin polymer films prepared by surface-initiated polymerization as a template for the fabrication of highly conformal metal nanoparticle solar cell electrodes. As a first proof-of-principle, the use of this metho ...

Herein the concept of tandem postpolymerization modification as a versatile route to synthesize well-defined, highly functionalized polymers is introduced. Poly(pentafluorophenyl methacrylate) obtained by atom transfer radical polymerization was first modi ...

Surface deposition is a critical step in the application of fragrance-containing products. This contribution presents a novel strategy to enhance the deposition of polymer-based fragrance delivery systems onto cotton substrates from the application medium ...

Polyelectrolyte brushes are responsive to salt in the environment, and this has found broad applications in antifouling, biolubrication, and drug delivery. Salt primarily influences the conformation of the polyelectrolytes through ion adsorption. While ion ...

Background: Immunotherapy consists of activating the patient's immune system to fight cancer and has the great potential of preventing future relapses thanks to immunological memory. A great variety of strategies have emerged to harness the immune system a ...

Cell mediated delivery of synthetic nano- and microparticle based drug carriers is a very promising strategy to enhance control over the distribution of drugs and improve targeting. This article will present an overview of work, which has been done to expl ...

This paper reports on the dilute, aqueous solution self-assembly of two asymmetric polystyrene-b-poly(L-lysine) (PSnPKm) diblock oligomers with PS and PK number-average degrees of polymerization of eight, respectively, 40 and 60. The self-assembly of these ...

The present work describes synthetic concepts for the coupling of peptides to polyphenylene dendrimers (PPDs). Novel functionalized cyclopentadienones have been synthesized whose Diels-Alder cycloaddition with various core molecules leads to polyphenylene ...

The coiled coil is a superhelical protein structural motif that consists of two or more alpha-helical peptides that are wrapped around each other in superhelical fashion. Coiled coils are amongst the most ubiquitous folding motifs found in proteins and hav ...

The feasibility of a new transfection agent, HBPL, for the production of recombinant IgG antibody via TGE as well as for the transfection of primary cells is studied. Under the conditions investigated, transfection of CHO-DG44 cells using HBPL results in I ...

Polymer brushes prepared via surface-initiated polymerization of 2-hydroxyethyl methacrylate are powerful platforms for the fabrication of model biointerfaces to study cell-substrate interactions. In this manuscript, the versatility of surface-initiated po ...

The covalent attachment of poly(ethylene glycol) (PEG) to therapeutically active proteins (PEGylation) has become an important method to deal with the pharmacological difficulties of these polypeptides, such as short body-residence times and immunogenicity ...

Thin, phenylboronic acid-containing polymer coatings are potentially attractive sensory layers for a range of glucose monitoring systems. This contribution presents the synthesis and properties of glucose-sensitive polymer brushes obtained via surface RAFT ...

The preparation of polymer gels via cross-linking of four-arm star-shaped poly(ethylene glycol) (Tetra-PEG) precursors is an attractive strategy to prepare networks with relatively well-defined topologies. Typically, Tetra-PEG gels are obtained by cross-li ...

Protein-polymer conjugates are a class of molecules that combine the stability of polymers with the diversity, specificity, and functionality of biomolecules. These bioconjugates can result in hybrid materials that display properties not found in their ind ...

Harm-Anton Klok

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Synthesis of Amino Acid-Based Aromatic Poly(Ester Urea)s Using 4-Hydroxycinnamic Acid-Derived Diols

Effect of Surface Charge on Surface-Initiated Atom Transfer Radical Polymerization from Cellulose Nanocrystals in Aqueous Media

Surface Modification of Polydimethylsiloxane Substrates with Nonfouling Poly(Poly(ethylene glycol)methacrylate) Brushes

Opportunities, Challenges, and Pitfalls in Making, Characterizing, and Understanding Polymer Brushes

Pyroelectric Polyelectrolyte Brushes

Polymer Brush Guided Formation of Conformal, Plasmonic Nanoparticle-Based Electrodes for Microwire Solar Cells

Side-Chain Peptide-Synthetic Polymer Conjugates via Tandem "Ester-Amide/Thiol-Ene" Post-Polymerization Modification of Poly(pentafluorophenyl methacrylate) Obtained Using ATRP

Peptide-Enhanced Selective Surface Deposition of Polymer-Based Fragrance Delivery Systems

Ion Adsorption Enhances Apparent Nonelectrostatic Attraction between Monomers in Polyelectrolyte Brushes

The era of bioengineering: how will this affect the next generation of cancer immunotherapy?

Cell-mediated delivery of synthetic nano- and microparticles funding

Aqueous solution self-assembly of polystyrene-b-poly(L-lysine) diblock oligomers

Polyphenylene dendrimers as scaffolds for shape-persistent multiple peptide conjugates

Coiled coils: attractive protein folding motifs for the fabrication of self-assembled, responsive and bioactive materials

Hyperbranched Polylysine: A Versatile, Biodegradable Transfection Agent for the Production of Recombinant Proteins by Transient Gene Expression and the Transfection of Primary Cells

Fibroblast adhesion on ECM-derived peptide modified poly(2-hydroxyethyl methacrylate) brushes: Ligand co-presentation and 3D-localization

Squaric Acid Mediated Chemoselective PEGylation of Proteins: Reactivity of Single-Step-Activated alpha-Amino Poly(ethylene glycol)s

Glucose-Sensitive QCM-Sensors Via Direct Surface RAFT Polymerization

Disulfide-Cross-Linked Tetra-PEG Gels

Self-assembly of protein-polymer conjugates for drug delivery