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Harm-Anton Klok

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Related publications (195)

Fibroblast adhesion on ECM-derived peptide modified poly(2-hydroxyethyl methacrylate) brushes: Ligand co-presentation and 3D-localization

Polymer brushes prepared via surface-initiated polymerization of 2-hydroxyethyl methacrylate are powerful platforms for the fabrication of model biointerfaces to study cell-substrate interactions. In this manuscript, the versatility of surface-initiated po ...

Elsevier2015

Oligonucleotide Immobilization and Hybridization on Aldehyde-Functionalized Poly(2-hydroxyethyl methacrylate) Brushes

Harm-Anton Klok, Tugba Bilgiç Tune

DNA biosensing requires high oligonudeotide binding capacity interface chemistries that can be tuned to maximize probe presentation as well as hybridization efficiency. This contribution investigates the feasibility of aldehyde-functionalized poly(2-hydrox ...

American Chemical Society2015

Avoiding compositional drift during the RAFT copolymerization of N-(2-hydroxypropyl)-methacrylamide and N-acryloxysuccinimide: towards uniform platforms for post-polymerization modification (vol 6, pg 3245, 2015)

Harm-Anton Klok, Hedi Ketari, Ioana-Maria Simionca, John Moraes

Royal Soc Chemistry2015

Expanding the Polymer Mechanochemistry Toolbox through Surface-Initiated Polymerization

Harm-Anton Klok

Surface-initiated polymerizations represent a versatile toolbox to generate densely grafted assemblies of chain end-tethered polymers. At sufficiently short interchain distances, surface-grafted polymers are forced into an extended chain conformation, whic ...

Amer Chemical Soc2015

Avoiding compositional drift during the RAFT copolymerization of N-(2-hydroxypropyl)methacrylamide and N-acryloxysuccinimide: towards uniform platforms for post-polymerization modification

Harm-Anton Klok, Hedi Ketari, Ioana-Maria Simionca, John Moraes

Controlled radical polymerization techniques such as RAFT allow fine control over polymer molecular weight and architecture. These techniques, however, do not eliminate compositional drifts in copolymerizations, which are the consequence of differences in ...

Royal Society of Chemistry2015

Polymeric Anti-HIV Therapeutics

Harm-Anton Klok, Maarten Danial

The scope of this review is to highlight the application of polymer therapeutics in an effort to curb the transmission and infection of the human immunodeficiency virus (HIV). Following a description of the HIV life cycle, the use of approved antiretrovira ...

Wiley-Blackwell2015

Glucose Monitoring Using a Polymer Brush Modified Polypropylene Hollow Fiber-based Hydraulic Flow Sensor

Harm-Anton Klok, Nicolas Fortin

Tight regulation of blood glucose levels of diabetic patients requires durable and robust continuous glucose sensing schemes. This manuscript reports the fabrication of ultrathin, phenylboronic acid (PBA) functionalized polymer brushes that swell upon gluc ...

Amer Chemical Soc2015

Identification of Soft Matter Binding Peptide Ligands Using Phage Display

Harm-Anton Klok

Phage display is a powerful tool for the selection of highly affine, short peptide ligands. While originally primarily used for the identification of ligands to proteins, the scope of this technique has significantly expanded over the past two decades. Pha ...

Amer Chemical Soc2015

Polypeptide brushes grown via surface-initiated ring-opening polymerization of alpha-amino acid N-carboxyanhydrides

Harm-Anton Klok

Polypeptide brushes are attractive platforms to generate functional and responsive interfaces that are of potential interest due to their possible biodegradability, biocompatibility and tunable secondary structures. Surface-initiated ringopening polymeriza ...

Springer Verlag2015

Polymer Brush Guided Formation of Conformal, Plasmonic Nanoparticle-Based Electrodes for Microwire Solar Cells

Harm-Anton Klok, Caroline Sugnaux, Anna Fontcuberta i Morral, Anna Dalmau Mallorquí

This report explores the use of sacrificial thin polymer films prepared by surface-initiated polymerization as a template for the fabrication of highly conformal metal nanoparticle solar cell electrodes. As a first proof-of-principle, the use of this metho ...

Wiley-Blackwell2015

Surface-initiated controlled radical polymerization enhanced DNA biosensing

Harm-Anton Klok, Tugba Bilgiç Tune

The surface chemistry at the DNA recognition and binding interface plays an important role in determining the performance of DNA microarrays and DNA biosensors. Surface-initiated controlled radical polymerization (SI-CRP) reactions represent a powerful too ...

2015

Shape-Persistent, Thermoresponsive Polypeptide Brushes Prepared by Vapor Deposition Surface-Initiated Ring-Opening Polymerization of alpha-Amino Acid N-Carboxyanhydrides

Harm-Anton Klok, Solenne Desseaux

Surface-grafting thermoresponsive polymers allows the preparation of thin polymer brush coatings with surface properties that can be manipulated by variation of temperature. In most instances, thermoresponsive polymer brushes are produced using polymers th ...

American Chemical Society2015

Polymer Brush Gradients Grafted from Plasma-Polymerized Surfaces

Harm-Anton Klok, Tugba Bilgiç Tune

A new method for generating a surface density gradient of polymer chains is presented. A substrate-independent polymer deposition technique was used to coat materials with a chemical gradient based on plasma copolymerization of 1,7-octadiene and allylamine ...

Amer Chemical Soc2014

Combating diseases with peptide - polymer conjugates

Harm-Anton Klok

Amer Chemical Soc2014

Functional polypeptide and hybrid materials: Precision synthesis via alpha-amino acid N-carboxyanhydride polymerization and emerging biomedical applications

Harm-Anton Klok

Polypeptides derived from naturally occurring a-amino acids have emerged as a unique and versatile family of bio-inspired biomaterials that can be tailor-made for varying biomedical applications such as controlled drug release, gene delivery, tissue engine ...

Elsevier2014

Glucose-Sensitive QCM-Sensors Via Direct Surface RAFT Polymerization

Harm-Anton Klok, Caroline Sugnaux

Thin, phenylboronic acid-containing polymer coatings are potentially attractive sensory layers for a range of glucose monitoring systems. This contribution presents the synthesis and properties of glucose-sensitive polymer brushes obtained via surface RAFT ...

Wiley-Blackwell2014

Squaric acid mediated bioconjugation expanded to polymers prepared by ATRP

Harm-Anton Klok, Frederik Roman Wurm

The squaric acid mediated bioconjugation reaction is an attractive approach for the amine-selective protein modification with side-chain functional polymers. This manuscript presents 3 squaric acid based atom transfer radical polymerization (ATRP) initiato ...

Royal Soc Chemistry2014

Surface and interface engineering with polymer brushes

Harm-Anton Klok

Amer Chemical Soc2014

Maleimide-Functionalized Thiol Reactive Copolymer Brushes: Fabrication and Post-Polymerization Modification

Harm-Anton Klok, Tugba Bilgiç Tune

Polymer brushes that present side chain functional reactive groups are attractive platforms for the development of functional surface coatings. From the wide spectrum of possible postpolymerization modification reactions, thiol-based conjugation chemistrie ...

American Chemical Society2014

Temperature-Controlled Masking/Unmasking of Cell-Adhesive Cues with Poly(ethylene glycol) Methacrylate Based Brushes

Harm-Anton Klok, Solenne Desseaux

Thin, thermoresponsive polymer coatings that allow to reversibly modulate cell adhesion and detachment are attractive substrates for cell sheet engineering. Usually, this is accomplished by applying thin poly(N-isopropylacrylamide) (PNIPAM) coatings, which ...

American Chemical Society2014

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