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Henry Markram

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Related publications (169)

Physically-based in silico light sheet microscopy for visualizing fluorescent brain models

Henry Markram, Felix Schürmann, Marwan Muhammad Ahmed Abdellah, Ahmet Bilgili, Stefan Eilemann

We present a physically-based computational model of the light sheet fluorescence microscope (LSFM). Based on Monte Carlo ray tracing and geometric optics, our method simulates the operational aspects and image formation process of the LSFM. This simulated ...

BioMed Central2015

Predictable enriched environment prevents development of hyper-emotionality in the VPA rat model of autism

Deborah La Mendola, Henry Markram, Kamila Markram, Mônica Regina Favre, Julie Meystre, Dimitri Marco Christodoulou, Melissa Cochrane

Understanding the effects of environmental stimulation in autism can improve therapeutic interventions against debilitating sensory overload, social withdrawal, fear and anxiety. Here, we evaluate the role of environmental predictability on behavior and pr ...

Frontiers Research Foundation2015

Anti-Obesity and Anti-Hyperglycemic Effects of Cinnamaldehyde via altered Ghrelin Secretion and Functional impact on Food Intake and Gastric Emptying

Henry Markram, Johannes Le Coutre, Julie Meystre, Maurizio Ferdinando Pezzoli, Susana Camacho Romero

Cinnamon extract is associated to different health benefits but the active ingredients or pathways are unknown. Cinnamaldehyde (CIN) imparts the characteristic flavor to cinnamon and is known to be the main agonist of transient receptor potential-ankyrin r ...

Nature Publishing Group2015

Reconstruction and Simulation of Neocortical Microcircuitry

Nenad Buncic, Jean-Vincent Le Bé, Selim Arsever, Henry Markram, Gilad Silberberg, Sébastien Lasserre, Vincent Delattre, Raphael Dumusc, Rodrigo de Campos Perin, Imad Riachi, Thomas Berger, Felix Schürmann, James Gonzalo King, Rajnish Ranjan, Srikanth Ramaswamy, Michael Lee Hines, Sean Lewis Hill, Juan Bautista Hernando Vieites, Georges Khazen, Shruti Muralidhar, Anastasia Ailamaki, Eilif Benjamin Muller, Farhan Tauheed, Jean Pierre Ghobril, Julie Meystre, Daniel Keller, Idan Segev, Michael Reimann, Thomas Heinis, John Richard Walker, Martin Telefont, Yun Wang, Ying Shi, Joseph William Graham, Marwan Muhammad Ahmed Abdellah, Julian Charles Shillcock, Jean-Denis Georges Emile Courcol, Ahmet Bilgili, Werner Alfons Hilda Van Geit, Athanassia Chalimourda, , , , , , , , , , , , , , , , , , , , , , , , , , , ,

An Exclusion Zone for Ca2+ Channels around Docked Vesicles Explains Release Control by Multiple Channels at a CNS Synapse

Henry Markram, Ralf Schneggenburger, Felix Schürmann, Yunyun Han, Olexiy Kochubey, Daniel Keller, Zsolt Norbert Babai

The spatial arrangement of Ca2+ channels and vesicles remains unknown for most CNS synapses, despite of the crucial importance of this geometrical parameter for the Ca2+ control of transmitter release. At a large model synapse, the calyx of Held, transmitt ...

Public Library Science2015

The future of human cerebral cartography: a novel approach

Henry Markram, Richard Frackowiak

Cerebral cartography can be understood in a limited, static, neuroanatomical sense. Temporal information from electrical recordings contributes information on regional interactions adding a functional dimension. Selective tagging and imaging of molecules a ...

Royal Soc2015

An algorithm to predict the connectome of neural microcircuits

Henry Markram, James Gonzalo King, Srikanth Ramaswamy, Eilif Benjamin Muller, Michael Reimann

Experimentally mapping synaptic connections, in terms of the numbers and locations of their synapses and estimating connection probabilities, is still not a tractable task, even for small volumes of tissue. In fact, the six layers of the neocortex contain ...

Frontiers Research Foundation2015

The neocortical microcircuit collaboration portal: a resource for rat somatosensory cortex

Selim Arsever, Henry Markram, Raphael Dumusc, Felix Schürmann, James Gonzalo King, Rajnish Ranjan, Srikanth Ramaswamy, Sean Lewis Hill, Juan Bautista Hernando Vieites, Eilif Benjamin Muller, Daniel Keller, Idan Segev, Michael Reimann, John Richard Walker, Martin Telefont, Yun Wang, Ying Shi, Joseph William Graham, Marwan Muhammad Ahmed Abdellah, Julian Charles Shillcock, Jean-Denis Georges Emile Courcol, Ahmet Bilgili, Werner Alfons Hilda Van Geit, Athanassia Chalimourda, Stefan Eilemann, Guy Antoine Atenekeng Kahou, Jeffrey Christopher Muller, Lida Kanari, Stefano Zaninetta, Giuseppe Chindemi, Jafet Villafranca Diaz, Yury Brukau, Michael Emiel Gevaert, Stanislaw Ryszard Adaszewski, Nicolas Antille

We have established a multi-constraint, data-driven process to digitally reconstruct, and simulate prototypical neocortical microcircuitry, using sparse experimental data. We applied this process to reconstruct the microcircuitry of the somatosensory corte ...

2015

OCTOPUS: Efficient Query Execution on Dynamic Mesh Datasets

Henry Markram, Felix Schürmann, Anastasia Ailamaki, Farhan Tauheed, Thomas Heinis

Scientists in many disciplines use spatial mesh models to study physical phenomena. Simulating natural phenomena by changing meshes over time helps to understand and predict future behavior of the phenomena. The higher the precision of the mesh models, the ...

2014

The death of Cajal and the end of scientific romanticism and individualism

Henry Markram

Elsevier Science London2014

Dampened neural activity and abolition of epileptic-like activity in cortical slices by active ingredients of spices

Henry Markram, Johannes Le Coutre, Julie Meystre, Maurizio Ferdinando Pezzoli, Susana Camacho Romero, Sara Lillian Gonzalez Andino

Active ingredients of spices (AIS) modulate neural response in the peripheral nervous system, mainly through interaction with TRP channel/receptors. The present study explores how different AIS modulate neural response in layer 5 pyramidal neurons of S1 ne ...

Nature Publishing Group2014

Distributor of neurons in a neocortical column

Henry Markram, Felix Schürmann, Georges Khazen, Martin Telefont

Computer-implemented methods, software, and systems for determining a distribution of neuronal cells across a portion of a brain are described. One computer-implemented method for determining a target distribution of one or more neuronal cells across a por ...

2014

Synaptic and cellular organization of layer 1 of the developing rat somatosensory cortex

Henry Markram, Shruti Muralidhar, Yun Wang

Layer 1 of the neocortex is sparsely populated with neurons and heavily innervated by fibers from lower layers and proximal and distal brain regions. Understanding the potential functions of this layer requires a comprehensive understanding of its cellular ...

Frontiers Research Foundation2014

Single-cell RT-PCR, a technique to decipher the electrical, anatomical, and genetic determinants of neuronal diversity

Henry Markram

The patch-clamp technique has allowed for detailed studies on the electrical properties of neurons. Dye loading through patch pipettes enabled characterizing the morphological properties of the neurons. In addition, the patch-clamp technique also allows fo ...

Springer2014

Computing the size and number of neuronal clusters in local circuits

Henry Markram, Rodrigo de Campos Perin, Martin Telefont

The organization of connectivity in neuronal networks is fundamental to understanding the activity and function of neural networks and information processing in the brain. Recent studies show that the neocortex is not only organized in columns and layers b ...

Frontiers Research Foundation2013

Neuroscience thinks big (and collaboratively)

Henry Markram

Despite cash-strapped times for research, several ambitious collaborative neuroscience projects have attracted large amounts of funding and media attention. In Europe, the Human Brain Project aims to develop a large-scale computer simulation of the brain, ...

2013

A Biophysically Detailed Model of Neocortical Local Field Potentials Predicts the Critical Role of Active Membrane Currents

Henry Markram, Rodrigo de Campos Perin, Sean Lewis Hill, Michael Reimann

Brain activity generates extracellular voltage fluctuations recorded as local field potentials (LFPs). It is known that the relevant microvariables, the ionic currents across membranes, jointly generate the macrovariables, the extracellular voltage, but ne ...

Elsevier2013

Seven challenges for neuroscience

Henry Markram

Although twenty-first century neuroscience is a major scientific enterprise, advances in basic research have not yet translated into benefits for society. In this paper, I outline seven fundamental challenges that need to be overcome. First, neuroscience h ...

2013

Preserving axosomatic spiking features despite diverse dendritic morphology

Henry Markram, Felix Schürmann, Idan Segev

Throughout the nervous system, cells belonging to a certain electrical class (e-class)-sharing high similarity in firing response properties-may nevertheless have widely variable dendritic morphologies. To quantify the effect of this morphological variabil ...

American Physiological Society2013

A computer-assisted multi-electrode patch-clamp system

Henry Markram, Rodrigo de Campos Perin

The patch-clamp technique is today the most well-established method for recording electrical activity from individual neurons or their subcellular compartments. Nevertheless, achieving stable recordings, even from individual cells, remains a time-consuming ...

Journal of Visualized Experiments2013

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Keerthan Muthurasa

Stefan Eilemann

Guy Antoine Atenekeng Kahou

Jeffrey Christopher Muller

Carlos Aguado Sanchez

Jafet Villafranca Diaz

Aleksandr Ovcharenko

Juan Luis Riquelme Roman

Benjamin Roy Morrice

James Alexander Dynes

Michael Emiel Gevaert

Juan Pablo Palacios

Pramod Shivaji Kumbhar

Ricardo Manuel Salgueiro Domingues Da Silva

Max Christian Nolte

Zoltan Kisvarday

Nicolas Antille

Lidia Alonso-Nanclares

Taylor Howard Newton

Alberto Munoz Cespedes

Anirudh Gupta

Michael John Kenyon

We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse ex ...

Elsevier2015

Frontiers Research Foundation