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Henry Markram

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Related publications (169)

Nlgn4 knockout induces network hypo-excitability in juvenile mouse somatosensory cortex in vitro

Deborah La Mendola, Henry Markram, Vincent Delattre, Kamila Markram, Julie Meystre

Neuroligins (Nlgns) are postsynaptic cell adhesion molecules that form transynaptic complexes with presynaptic neurexins and regulate synapse maturation and plasticity. We studied the impact of the loss of Nlgn4 on the excitatory and inhibitory circuits in ...

Nature Publishing Group2013

General developmental health in the VPA-rat model of autism

Henry Markram, Kamila Markram, Mônica Regina Favre, Georges Khazen

Autism is a neurodevelopmental condition diagnosed by impaired social interaction, abnormal communication and, stereotyped behaviors. While post-mortem and imaging studies have provided good insights into the neurobiological symptomology of autism, animal ...

Frontiers Research Foundation2013

New insights into the classification and nomenclature of cortical GABAergic interneurons

Henry Markram, Jean Rossier, Sean Lewis Hill, Yun Wang, Zoltan Kisvarday, Ruth Benavides Piccione

A systematic classification and accepted nomenclature of neuron types is much needed but is currently lacking. This article describes a possible taxononnical solution for classifying GABAergic interneurons of the cerebral cortex based on a novel, web-based ...

Nature Publishing Group2013

A Hierarchical Structure of Cortical Interneuron Electrical Diversity Revealed by Automated Statistical Analysis

Henry Markram, Felix Schürmann, Sean Lewis Hill, Idan Segev

Although the diversity of cortical interneuron electrical properties is well recognized, the number of distinct electrical types (e-types) is still a matter of debate. Recently, descriptions of interneuron variability were standardized by multiple laborato ...

Oxford University Press2013

One minute with ... Henry Markram

Henry Markram

Reed Business Information Ltd2013

Matched Pre- and Post-Synaptic Changes Underlie Synaptic Plasticity over Long Time Scales

Jean-Vincent Le Bé, Henry Markram

Modifications of synaptic efficacies are considered essential for learning and memory. However, it is not known how the underlying functional components of synaptic transmission change over long time scales. To address this question, we studied cortical sy ...

Soc Neuroscience2013

Accelerating Range Queries For Brain Simulations

Henry Markram, Felix Schürmann, Anastasia Ailamaki, Farhan Tauheed, Thomas Heinis, Laurynas Biveinis

Neuroscientists increasingly use computational tools to build and simulate models of the brain. The amounts of data involved in these simulations are immense and the importance of their efficient management is primordial. One particular problem in analyzin ...

2012

Method for in-vitro monitoring of neuronal disorders and use thereof

Luca Gambazzi, Henry Markram, Michele Giugliano

The present invention relates to methods and neuronal cellular preparations allowing monitoring intracellular and transcellular molecular events on both short and long timescales in an ex vivo neuronal network of intact post-mitotic neurons. In particular, ...

2012

Intrinsic morphological diversity of thick-tufted layer 5 pyramidal neurons ensures robust and invariant properties of in silico synaptic connections

Henry Markram, Felix Schürmann, Srikanth Ramaswamy, Yun Wang

The morphology of neocortical pyramidal neurons is not only highly characteristic but also displays an intrinsic diversity that renders each neuron morphologically unique. We investigated the significance of this intrinsic morphological diversity in in sil ...

2012

SCOUT: Prefetching for Latent Structure Following Queries

Henry Markram, Felix Schürmann, Anastasia Ailamaki, Farhan Tauheed, Thomas Heinis

Today's scientists are quickly moving from in vitro to in silico experimentation: they no longer analyze natural phenomena in a petri dish, but instead they build models and simulate them. Managing and analyzing the massive amounts of data involved in simu ...

2012

The human brain project

Henry Markram

2012

Short-term ionic plasticity at GABAergic synapses

Henry Markram

Fast synaptic inhibition in the brain is mediated by the pre-synaptic release of the neurotransmitter γ-Aminobutyric acid (GABA)and the post-synaptic activation of GABA-sensitive ionotropic receptors. As with excitatory synapses, it is being increasinly ap ...

2012

A neuron membrane mesh representation for visualization of electrophysiological simulations

Henry Markram, Sébastien Lasserre, Felix Schürmann, Sean Lewis Hill, Juan Bautista Hernando Vieites

We present a process to automatically generate three-dimensional mesh representations of the complex, arborized cell membrane surface of cortical neurons (the principal information processing cells of the brain) from nonuniform morphological measurements. ...

Institute of Electrical and Electronics Engineers2012

Combinatorial expression rules of ion channel genes in juvenile rat (Rattus norvegicus) neocortical neurons

Henry Markram, Felix Schürmann, Georges Khazen

The electrical diversity of neurons arises from the expression of different combinations of ion channels. The gene expression rules governing these combinations are not known. We examined the expression of twenty-six ion channel genes in a broad range of s ...

Public Library of Science2012

Statistical connectivity provides a sufficient foundation for specific functional connectivity in neocortical neural microcircuits

Henry Markram, Imad Riachi, Felix Schürmann, Yun Wang

It is well-established that synapse formation involves highly selective chemospecific mechanisms, but how neuron arbors are positioned before synapse formation remains unclear. Using 3D reconstructions of 298 neocortical cells of different types (including ...

Natl Acad Sciences2012

The neocortical column

Henry Markram

Frontiers Research Foundation2012

Spike-timing-dependent plasticity: a comprehensive overview

Wulfram Gerstner, Henry Markram

2012

Morphological development of thick-tufted layer v pyramidal cells in the rat somatosensory cortex

Henry Markram, Sandrine Romand, Yun Wang

The thick-tufted layer V pyramidal (TTL5) neuron is a key neuron providing output from the neocortex. Although it has been extensively studied, principles governing its dendritic and axonal arborization during development are still not fully quantified. Us ...

2011

Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties

Henry Markram, Felix Schürmann, Sean Lewis Hill, Idan Segev

The thick-tufted layer 5b pyramidal cell extends its dendritic tree to all six layers of the mammalian neocortex and serves as a major building block for the cortical column. L5b pyramidal cells have been the subject of extensive experimental and modeling ...

2011

A synaptic organizing principle for cortical neuronal groups

Henry Markram, Rodrigo de Campos Perin, Thomas Berger

Neuronal circuitry is often considered a clean slate that can be dynamically and arbitrarily molded by experience. However, when we investigated synaptic connectivity in groups of pyramidal neurons in the neocortex, we found that both connectivity and syna ...

2011

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