IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases

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The ability to remotely control the activity of chimeric antigen receptors (CARs) with small molecules can improve the safety and efficacy of gene-modified T cells. Split ON- or OFF-switch CARs involve the dissociation of tumor–antigen binding from T cell ...

Background aims: Age-related macular degeneration (AMD) is the most common cause of blindness in elderly patients within developed countries, affecting more than 190 million worldwide. In AMD, the retinal pigment epithelial (RPE) cell layer progressively d ...

Despite the remarkable success of immune checkpoint blockade (ICB) therapy, most cancer patients still do not respond. We now find that immunotherapy can induce stem-like properties in tumors. Using mouse models of breast cancer, we observe that cancer ste ...

One key barrier to improving efficacy of personalized cancer immunotherapies that are dependent on the tumor antigenic landscape remains patient stratification. Although patients with CD3+CD8+ T cell-inflamed tumors typically show better response to immune ...

Hand tendon/ligament structural ruptures (tears, lacerations) often require surgical reconstruction and grafting, for the restauration of finger mechanical functions. Clinical-grade human primary progenitor tenocytes (FE002 cryopreserved progenitor cell so ...

Background Activin-A, a transforming growth factor beta family member, is secreted by many cancer types and is often associated with poor disease prognosis. Previous studies have shown that Activin-A expression can promote cancer progression and reduce the ...

Muscle stem cells (MuSCs) are the primary source of myogenic progenitors during muscle repair and are essential for the long-term regenerative capacity of skeletal muscle. Following myofiber injury, MuSCs transition from a quiescent to an activated state, ...

Simple Summary Breast cancer stem cells are a subset of transformed cells that sustain tumor growth and can metastasize to secondary organs. Since metastasis accounts for most cancer deaths, it is of paramount importance to understand the cellular and mole ...

In the context of adoptive T cell transfer (ACT) for cancer treatment, it is crucial to generate in vitro large amounts of tumor-specific CD8 T cells with high potential to persist in vivo. PD-1, Tim3, and CD39 have been proposed as markers of tumor-specif ...

BACKGROUND: Helminth parasites have been reported to have beneficial immunomodulatory effects in patients with allergic and autoimmune conditions and detrimental consequences in patients with tuberculosis and some viral infections. Their role in coinfectio ...

Performance-based earthquake engineering requires numerical models that are able to reliably predict the expected component behavior of buildings under seismic excitations. The nonlinear modeling guidelines provided in ASCE-41-13 have historically been use ...

Vaccination has been regarded to as the most attractive immunotherapy for cancer because of its ability to instruct immune cells to recognize and kill tumor cells. Exosomes are one of the most recent discoveries translated from basic biology into experimen ...

Fibroblast-like cells of secondary lymphoid organs (SLO) are important for tissue architecture. In addition, they regulate lymphocyte compartmentalization through the secretion of chemokines, and participate in the orchestration of appropriate cell-cell in ...

Peripheral arterial disease (PAD) is a common disease with increasing prevalence, presenting with impaired walking ability affecting patient's quality of life. PAD epidemiology is known, however, mechanisms underlying functional muscle impairment remain un ...

Indoleamine 2,3-dioxygenase 1 (IDO1) is a key regulator of immune responses and therefore an important therapeutic target for the treatment of diseases that involve pathological immune escape, such as cancer. Here, we describe a robust and sensitive high-t ...

The physicochemical properties of hydrogels can be manipulated in both space and time through the controlled application of a light beam. However, methods for hydrogel photopatterning either fail to maintain the bioactivity of fragile proteins and are thus ...

IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases

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Dual ON/OFF-switch chimeric antigen receptor controlled by two clinically approved drugs

Clinically compliant cryopreservation of differentiated retinal pigment epithelial cells

IFNγ-induced stem-like state of cancer cells as a driver of metastatic progression following immunotherapy

The immunopeptidome landscape associated with T cell infiltration, inflammation and immune editing in lung cancer

Bio-Enhanced Neoligaments Graft Bearing FE002 Primary Progenitor Tenocytes: Allogeneic Tissue Engineering & Surgical Proofs-of-Concept for Hand Ligament Regenerative Medicine

Activin-A impairs CD8 T cell-mediated immunity and immune checkpoint therapy response in melanoma

Molecular Regulation of Muscle Stem Cell Fate during Skeletal Muscle Regeneration and Aging

The Tumor Microenvironment as a Driving Force of Breast Cancer Stem Cell Plasticity

Enhanced Phenotype Definition for Precision Isolation of Precursor Exhausted Tumor-Infiltrating CD8 T Cells

Enteric helminth-induced type I interferon signaling protects against pulmonary virus infection through interaction with the microbiota

Updates to the ASCE-41-13 Provisions for the Nonlinear Modeling of Steel Wide-Flange Columns for Performance-based Earthquake Engineering

Bioengineering approaches in immunotherapy : from basic to translational applications

Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses

Engineering adjuvants for prophylactic and therapeutic subunit vaccines

Experimental peripheral arterial disease: new insights into muscle glucose uptake, macrophage, and T-cell polarization during early and late stages

Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors

Development of Novel Nanoparticle-Based Vaccines and Immunotherapies : Tuberculosis, Lung Metastasis and Allergy as Models

In situ cell manipulation through enzymatic hydrogel photopatterning