Publications related to IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases

Related publications (19)

Dual ON/OFF-switch chimeric antigen receptor controlled by two clinically approved drugs

Bruno Emanuel Ferreira De Sousa Correia, Sandrine Madeleine Suzanne Georgeon, Leo Scheller, Sailan Shui

The ability to remotely control the activity of chimeric antigen receptors (CARs) with small molecules can improve the safety and efficacy of gene-modified T cells. Split ON- or OFF-switch CARs involve the dissociation of tumor–antigen binding from T cell ...

National Academy of Sciences2024

Tuberculosis in otherwise healthy adults with inherited TNF deficiency

Alessandro Borghesi

Severe defects in human IFN gamma immunity predispose individuals to both Bacillus Calmette-Gu & eacute;rin disease and tuberculosis, whereas milder defects predispose only to tuberculosis1. Here we report two adults with recurrent pulmonary tuberculosis w ...

NATURE PORTFOLIO2024

Clinically compliant cryopreservation of differentiated retinal pigment epithelial cells

Cheng Zhao, Gioele La Manno, Alex Russell Lederer

Background aims: Age-related macular degeneration (AMD) is the most common cause of blindness in elderly patients within developed countries, affecting more than 190 million worldwide. In AMD, the retinal pigment epithelial (RPE) cell layer progressively d ...

Elsevier Sci Ltd2024

IFNγ-induced stem-like state of cancer cells as a driver of metastatic progression following immunotherapy

Jörg Hülsken, Maxim Norkin, Angela Madurga Alonso, Laurent Nam Ky Beziaud

Despite the remarkable success of immune checkpoint blockade (ICB) therapy, most cancer patients still do not respond. We now find that immunotherapy can induce stem-like properties in tumors. Using mouse models of breast cancer, we observe that cancer ste ...

Elsevier BV2023

The immunopeptidome landscape associated with T cell infiltration, inflammation and immune editing in lung cancer

Didier Trono, Evaristo Jose Planet Letschert, Laia Simo Riudalbas

One key barrier to improving efficacy of personalized cancer immunotherapies that are dependent on the tumor antigenic landscape remains patient stratification. Although patients with CD3+CD8+ T cell-inflamed tumors typically show better response to immune ...

2023

Bio-Enhanced Neoligaments Graft Bearing FE002 Primary Progenitor Tenocytes: Allogeneic Tissue Engineering & Surgical Proofs-of-Concept for Hand Ligament Regenerative Medicine

Corinne Scaletta, Lee Ann Laurent-Applegate, Sandra Jaccoud, Philippe Abdel Sayed, Nathalie Hirt-Burri, Laurent Alexis Clément Vannay

Hand tendon/ligament structural ruptures (tears, lacerations) often require surgical reconstruction and grafting, for the restauration of finger mechanical functions. Clinical-grade human primary progenitor tenocytes (FE002 cryopreserved progenitor cell so ...

MDPI2023

Activin-A impairs CD8 T cell-mediated immunity and immune checkpoint therapy response in melanoma

Daniel Constam, Etienne Meylan, Julien Robert Rémi Faget, Katarina Pinjusic, Olivier Andreas Dubey, Olga Egorova

Background Activin-A, a transforming growth factor beta family member, is secreted by many cancer types and is often associated with poor disease prognosis. Previous studies have shown that Activin-A expression can promote cancer progression and reduce the ...

BMJ PUBLISHING GROUP2022

Molecular Regulation of Muscle Stem Cell Fate during Skeletal Muscle Regeneration and Aging

Sara Ancel

Muscle stem cells (MuSCs) are the primary source of myogenic progenitors during muscle repair and are essential for the long-term regenerative capacity of skeletal muscle. Following myofiber injury, MuSCs transition from a quiescent to an activated state, ...

EPFL2022

The Tumor Microenvironment as a Driving Force of Breast Cancer Stem Cell Plasticity

Albert Santamaria Martinez

Simple Summary Breast cancer stem cells are a subset of transformed cells that sustain tumor growth and can metastasize to secondary organs. Since metastasis accounts for most cancer deaths, it is of paramount importance to understand the cellular and mole ...

2020

Enhanced Phenotype Definition for Precision Isolation of Precursor Exhausted Tumor-Infiltrating CD8 T Cells

Pedro Romero, Amaia Martinez Usatorre

In the context of adoptive T cell transfer (ACT) for cancer treatment, it is crucial to generate in vitro large amounts of tumor-specific CD8 T cells with high potential to persist in vivo. PD-1, Tim3, and CD39 have been proposed as markers of tumor-specif ...

2020

Enteric helminth-induced type I interferon signaling protects against pulmonary virus infection through interaction with the microbiota

Nicola Harris

BACKGROUND: Helminth parasites have been reported to have beneficial immunomodulatory effects in patients with allergic and autoimmune conditions and detrimental consequences in patients with tuberculosis and some viral infections. Their role in coinfectio ...

Elsevier2017

Updates to the ASCE-41-13 Provisions for the Nonlinear Modeling of Steel Wide-Flange Columns for Performance-based Earthquake Engineering

Dimitrios Lignos, Alexander Riley Hartloper

Performance-based earthquake engineering requires numerical models that are able to reliably predict the expected component behavior of buildings under seismic excitations. The nonlinear modeling guidelines provided in ASCE-41-13 have historically been use ...

2017

Bioengineering approaches in immunotherapy : from basic to translational applications

Martina Damo

Vaccination has been regarded to as the most attractive immunotherapy for cancer because of its ability to instruct immune cells to recognize and kill tumor cells. Exosomes are one of the most recent discoveries translated from basic biology into experimen ...

EPFL2016

Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses

Freddy Radtke, Ute Koch, Nicolas Fasnacht

Fibroblast-like cells of secondary lymphoid organs (SLO) are important for tissue architecture. In addition, they regulate lymphocyte compartmentalization through the secretion of chemokines, and participate in the orchestration of appropriate cell-cell in ...

Rockefeller University Press2014

Engineering adjuvants for prophylactic and therapeutic subunit vaccines

Alexandre de Titta

EPFL2014

Experimental peripheral arterial disease: new insights into muscle glucose uptake, macrophage, and T-cell polarization during early and late stages

Rolf Gruetter, Carole Poitry-Yamate

Peripheral arterial disease (PAD) is a common disease with increasing prevalence, presenting with impaired walking ability affecting patient's quality of life. PAD epidemiology is known, however, mechanisms underlying functional muscle impairment remain un ...

2014

Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors

Pierre Vogel, Gerardo Turcatti, Marc Chambon, Somi Reddy Majjigapu

Indoleamine 2,3-dioxygenase 1 (IDO1) is a key regulator of immune responses and therefore an important therapeutic target for the treatment of diseases that involve pathological immune escape, such as cancer. Here, we describe a robust and sensitive high-t ...

Elsevier France-Editions Scientifiques Medicales Elsevier2014

Development of Novel Nanoparticle-Based Vaccines and Immunotherapies : Tuberculosis, Lung Metastasis and Allergy as Models

Marie Ballester

EPFL2013

In situ cell manipulation through enzymatic hydrogel photopatterning

Jeffrey Alan Hubbell, Matthias Lütolf, Katarzyna Mosiewicz, Laura Kolb

The physicochemical properties of hydrogels can be manipulated in both space and time through the controlled application of a light beam. However, methods for hydrogel photopatterning either fail to maintain the bioactivity of fragile proteins and are thus ...

Nature Publishing Group2013