Publications associées à Translating questions to estimands in randomized clinical trials with intercurrent events

Publications associées (38)

User-centric Reflective Writing Assistance: Leveraging RAG for Enhanced Personalized Support

Tanja Christina Käser Jacober, Paola Mejia Domenzain, Seyed Parsa Neshaei, Matea Tashkovska

Reflective writing, a valuable educational practice, helps learners analyze their thoughts and experiences. However, learners often struggle to translate their experiences and thoughts into written form. Recent advancements in large language models (LLMs) ...

ACM2025

Using Negative Control Populations to Assess Unmeasured Confounding and Direct Effects

Mats Julius Stensrud

Sometimes treatment effects are absent in a subgroup of the population. For example, penicillin has no effect on severe symptoms in individuals infected by resistant Staphylococcus aureus, and codeine has no effect on pain in individuals with certain polym ...

Lippincott Williams & Wilkins2024

A First-in-Human Randomized Study to Assess the Safety, Tolerability, Pharmacokinetics, and Neutralization Profile of Two Investigational Long-Acting Anti-SARS-CoV-2 Monoclonal Antibodies

Didier Trono, Norman Lionel Moullan

Introduction: COVID-19 remains a significant risk for the immunocompromised given their lower responsiveness to vaccination or infection. Therefore, passive immunity through long-acting monoclonal antibodies (mAbs) offers a needed approach for pre-exposure ...

2024

Biases in Information Selection and Processing: Survey Evidence from the Pandemic

Andreas Fuster

We conduct two survey experiments to study which information people choose to consume and how it affects their beliefs. In the first experiment, respondents choose between optimistic and pessimistic article headlines related to the COVID-19 pandemic and ar ...

2024

The role of spatial epidemiology to support public health policies : case studies applied to health promotion, noncommunicable and infectious diseases in the canton of Vaud, Switzerland

Anaïs Laurence Ladoy

In a context of escalating public health challenges, including the rise of chronic diseases, the impact of climate change, and the COVID-19 pandemic, certain populations bear a disproportionate burden. As a result, there is an urgent need to develop public ...

EPFL2024

Optimal regimes for algorithm-assisted human decision-making

Mats Julius Stensrud, Aaron Leor Sarvet, Julien David Laurendeau

We consider optimal regimes for algorithm-assisted human decision-making. Such regimes are decision functions of measured pre-treatment variables and, by leveraging natural treatment values, enjoy a superoptimality property whereby they are guaranteed to o ...

2024

Interventionist estimands in event history analysis

Matias Janvin

The presence of competing events, such as death, makes it challenging to define causal effects on recurrent outcomes. In this thesis, I formalize causal inference for recurrent events, with and without competing events. I define several causal estimands an ...

EPFL2023

Modeling tumor size dynamics based on real-world electronic health records and image data in advanced melanoma patients receiving immunotherapy

Federico Amato

The development of immune checkpoint inhibitors (ICIs) has revolutionized cancer therapy but only a fraction of patients benefits from this therapy. Model-informed drug development can be used to assess prognostic and predictive clinical factors or biomark ...

2023

Semiclassical Estimates for Eigenvalue Means of Laplacians on Spheres

Davide Buoso, Joachim Stubbe, Luigi Provenzano

We compute three-term semiclassical asymptotic expansions of counting functions and Riesz-means of the eigenvalues of the Laplacian on spheres and hemispheres, for both Dirichlet and Neumann boundary conditions. Specifically for Riesz-means we prove upper ...

SPRINGER2023

Translational screening platform to evaluate chemotherapy in combination with focal therapy for retinoblastoma

Paul Joseph Dyson, Valentin Simeonov, Fabien Kuttler, Patrik Aouad, Irina Sinenko

Retinoblastoma is the most common pediatric eye cancer. It is currently treated with a limited number of drugs, adapted from other pediatric cancer treatments. Drug toxicity and relapse of the disease warrant new therapeutic strategies for these young pati ...

WILEY2023

Optimised three-dimensional in vitro retinoblastoma models tailored for drug discovery and clinical translatability

Irina Sinenko

Retinoblastoma, while relatively rare, stands as the most prevalent intraocular cancer. In Switzerland, the survival rate approaches 100%, but it drops to less than 50% in low-income countries. The current treatment options for retinoblastoma rely on a lim ...

EPFL2023

The predictive capacity of in vitro preclinical models to evaluate drugs for the treatment of retinoblastoma

Paul Joseph Dyson, Irina Sinenko, Roland Christopher Turnell-Ritson

Retinoblastoma is a rare childhood cancer of the eye. Of the small number of drugs are used to treat retinoblastoma, all have been repurposed from drugs developed for other conditions. In order to find drugs or drug combinations better suited to the improv ...

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD2023

Some Physical Implications Of Absolute Geometries In The Description Of Complex Systems Dynamics

Maria-Alexandra Paun

Some implications of absolute geometries in the description of complex systems dynamics, at various scale resolutions are highlighted. In such context, by means of an analytic geometry of 2 x 2 matrices, a generalization of the standard velocities space in ...

UNIV POLITEHNICA BUCHAREST, SCI BULL2023

A new variable shape parameter strategy for RBF approximation using neural networks

Jan Sickmann Hesthaven

The choice of the shape parameter highly effects the behaviour of radial basis function (RBF) approximations, as it needs to be selected to balance between the ill-conditioning of the interpolation matrix and high accuracy. In this paper, we demonstrate ho ...

PERGAMON-ELSEVIER SCIENCE LTD2023

Abundance theorem for threefolds in mixed characteristic

Fabio Bernasconi

We prove the abundance theorem for arithmetic klt threefold pairs whose closed point have residue characteristic greater than 5. As a consequence, we give a sufficient condition for the asymptotic invariance of plurigenera for certain families of singular ...

2022

Scrambler Therapy for Chronic Pain after Burns and Its Effect on the Cerebral Pain Network: A Prospective, Double-Blinded, Randomized Controlled Trial

Chang-Hyun Park

Chronic pain is common after burn injuries, and post-burn neuropathic pain is the most important complication that is difficult to treat. Scrambler therapy (ST) is a non-invasive modality that uses patient-specific electrocutaneous nerve stimulation and is ...

MDPI2022

The N-Clock Model: Variational Analysis for Fast and Slow Divergence Rates of N

Matthias Benjamin Ruf

We study a nearest neighbors ferromagnetic classical spin system on the square lattice in which the spin field is constrained to take values in a discretization of the unit circle consisting of N equi-spaced vectors, also known as the N-clock model. We fin ...

2022

Identifying a Motivational Profile for Older Adults Towards Increased Physical Activity

Pearl Pu Faltings

Personalizing behavior change (BC) strategies to motivate increased physical activity is especially important for the diverse older adult population. However, there is a lack of knowledge about how to profile older users to most effectively personalize BC ...

2021

Decision Framework to Balance Environmental, Technical, Logistical, and Economic Criteria When Designing Structures With Reused Components

Corentin Jean Dominique Fivet, Numa Joy Bertola, Jan Friedrich Georg Brütting, Célia Marine Küpfer

The reuse of structural components in new buildings has great potential to reduce the environmental impacts of the construction sector but remains uncommon practice. An obstacle to its wider implementation is the lack of robust assessment methods and decis ...

2021

Finite torsors over strongly F-regular singularities

Javier Alonso Carvajal Rojas

We investigate finite torsors over big opens of spectra of strongly F-regular germs that do not extend to torsors over the whole spectrum. Let (R, m, k, K) be a strongly F-regular k-germ where k is an algebraically closed field of characteristic p > 0. We ...

2022