Translating questions to estimands in randomized clinical trials with intercurrent events

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

Reflective writing, a valuable educational practice, helps learners analyze their thoughts and experiences. However, learners often struggle to translate their experiences and thoughts into written form. Recent advancements in large language models (LLMs) ...

Sometimes treatment effects are absent in a subgroup of the population. For example, penicillin has no effect on severe symptoms in individuals infected by resistant Staphylococcus aureus, and codeine has no effect on pain in individuals with certain polym ...

Introduction: COVID-19 remains a significant risk for the immunocompromised given their lower responsiveness to vaccination or infection. Therefore, passive immunity through long-acting monoclonal antibodies (mAbs) offers a needed approach for pre-exposure ...

We conduct two survey experiments to study which information people choose to consume and how it affects their beliefs. In the first experiment, respondents choose between optimistic and pessimistic article headlines related to the COVID-19 pandemic and ar ...

In a context of escalating public health challenges, including the rise of chronic diseases, the impact of climate change, and the COVID-19 pandemic, certain populations bear a disproportionate burden. As a result, there is an urgent need to develop public ...

We consider optimal regimes for algorithm-assisted human decision-making. Such regimes are decision functions of measured pre-treatment variables and, by leveraging natural treatment values, enjoy a superoptimality property whereby they are guaranteed to o ...

The presence of competing events, such as death, makes it challenging to define causal effects on recurrent outcomes. In this thesis, I formalize causal inference for recurrent events, with and without competing events. I define several causal estimands an ...

The development of immune checkpoint inhibitors (ICIs) has revolutionized cancer therapy but only a fraction of patients benefits from this therapy. Model-informed drug development can be used to assess prognostic and predictive clinical factors or biomark ...

We compute three-term semiclassical asymptotic expansions of counting functions and Riesz-means of the eigenvalues of the Laplacian on spheres and hemispheres, for both Dirichlet and Neumann boundary conditions. Specifically for Riesz-means we prove upper ...

Retinoblastoma is the most common pediatric eye cancer. It is currently treated with a limited number of drugs, adapted from other pediatric cancer treatments. Drug toxicity and relapse of the disease warrant new therapeutic strategies for these young pati ...

Retinoblastoma, while relatively rare, stands as the most prevalent intraocular cancer. In Switzerland, the survival rate approaches 100%, but it drops to less than 50% in low-income countries. The current treatment options for retinoblastoma rely on a lim ...

Retinoblastoma is a rare childhood cancer of the eye. Of the small number of drugs are used to treat retinoblastoma, all have been repurposed from drugs developed for other conditions. In order to find drugs or drug combinations better suited to the improv ...

Some implications of absolute geometries in the description of complex systems dynamics, at various scale resolutions are highlighted. In such context, by means of an analytic geometry of 2 x 2 matrices, a generalization of the standard velocities space in ...

The choice of the shape parameter highly effects the behaviour of radial basis function (RBF) approximations, as it needs to be selected to balance between the ill-conditioning of the interpolation matrix and high accuracy. In this paper, we demonstrate ho ...

We prove the abundance theorem for arithmetic klt threefold pairs whose closed point have residue characteristic greater than 5. As a consequence, we give a sufficient condition for the asymptotic invariance of plurigenera for certain families of singular ...

Chronic pain is common after burn injuries, and post-burn neuropathic pain is the most important complication that is difficult to treat. Scrambler therapy (ST) is a non-invasive modality that uses patient-specific electrocutaneous nerve stimulation and is ...

We study a nearest neighbors ferromagnetic classical spin system on the square lattice in which the spin field is constrained to take values in a discretization of the unit circle consisting of N equi-spaced vectors, also known as the N-clock model. We fin ...

Personalizing behavior change (BC) strategies to motivate increased physical activity is especially important for the diverse older adult population. However, there is a lack of knowledge about how to profile older users to most effectively personalize BC ...

The reuse of structural components in new buildings has great potential to reduce the environmental impacts of the construction sector but remains uncommon practice. An obstacle to its wider implementation is the lack of robust assessment methods and decis ...

We investigate finite torsors over big opens of spectra of strongly F-regular germs that do not extend to torsors over the whole spectrum. Let (R, m, k, K) be a strongly F-regular k-germ where k is an algebraically closed field of characteristic p > 0. We ...

Translating questions to estimands in randomized clinical trials with intercurrent events

Chat with Graph Search

User-centric Reflective Writing Assistance: Leveraging RAG for Enhanced Personalized Support

Using Negative Control Populations to Assess Unmeasured Confounding and Direct Effects

A First-in-Human Randomized Study to Assess the Safety, Tolerability, Pharmacokinetics, and Neutralization Profile of Two Investigational Long-Acting Anti-SARS-CoV-2 Monoclonal Antibodies

Biases in Information Selection and Processing: Survey Evidence from the Pandemic

The role of spatial epidemiology to support public health policies : case studies applied to health promotion, noncommunicable and infectious diseases in the canton of Vaud, Switzerland

Optimal regimes for algorithm-assisted human decision-making

Interventionist estimands in event history analysis

Modeling tumor size dynamics based on real-world electronic health records and image data in advanced melanoma patients receiving immunotherapy

Semiclassical Estimates for Eigenvalue Means of Laplacians on Spheres

Translational screening platform to evaluate chemotherapy in combination with focal therapy for retinoblastoma

Optimised three-dimensional in vitro retinoblastoma models tailored for drug discovery and clinical translatability

The predictive capacity of in vitro preclinical models to evaluate drugs for the treatment of retinoblastoma

Some Physical Implications Of Absolute Geometries In The Description Of Complex Systems Dynamics

A new variable shape parameter strategy for RBF approximation using neural networks

Abundance theorem for threefolds in mixed characteristic

Scrambler Therapy for Chronic Pain after Burns and Its Effect on the Cerebral Pain Network: A Prospective, Double-Blinded, Randomized Controlled Trial

The N-Clock Model: Variational Analysis for Fast and Slow Divergence Rates of N

Identifying a Motivational Profile for Older Adults Towards Increased Physical Activity

Decision Framework to Balance Environmental, Technical, Logistical, and Economic Criteria When Designing Structures With Reused Components

Finite torsors over strongly F-regular singularities