Publications associées à Establishment of a microwell-array-based miniaturized thymic organoid model suitable for high-throughput applications

Publications associées (10)

Exploring the interplay of molecular pattern and valency for selective interactions at the bio-interface

Cell-cell communication is fundamental for immune balance. Multivalent interactions of surface receptors at immune interfaces drive specific communication, with stimulatory and inhibitory signals guiding the immune outcome. Notably, the valency, affinity, ...

EPFL2023

Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14

Kathrin Tomasek

A key attribute of persistent or recurring bacterial infections is the ability of the pathogen to evade the host's immune response. Many Enterobacteriaceae express type 1 pili, a pre-adapted virulence trait, to invade host epithelial cells and establish pe ...

eLIFE SCIENCES PUBL LTD2022

Regulatory T cells engineered with TCR signaling-responsive IL-2 nanogels suppress alloimmunity in sites of antigen encounter

Li Tang, Na Li

Adoptive cell transfer of ex vivo expanded regulatory T cells (T-r(egs)) has shown immense potential in animal models of auto- and alloimmunity. However, the effective translation of such T-reg therapies to the clinic has been slow. Because T-reg homeostas ...

2020

Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose

Jeffrey Alan Hubbell, Melody Swartz, Alexandre de Titta, Marie Ballester, Laura Jeanbart, Ziad Julier

In subunit vaccines, strong CD8(+) T-cell responses are desired, yet they are elusive at reasonable adjuvant doses. We show that targeting adjuvant to the lymph node (LN) via ultrasmall polymeric nanoparticles (NPs), which rapidly drain to the LN after int ...

National Academy of Sciences2013

PPS nanoparticles as versatile delivery system to induce systemic and broad mucosal immunity after intranasal administration

Jeffrey Alan Hubbell, Melody Swartz

Degradable polymer nanoparticles (NPs, 50nm) based on polypropylene sulfide (PPS) were conjugated to thiolated antigen and adjuvant proteins by reversible disulfide bonds and evaluated in mucosal vaccination. Ovalbumin was used as a model antigen, and anti ...

Elsevier2011

Cell viability assessment by flow cytometry using yeast as cell model

Philippe Renaud, Niccolo Piacentini, Nina Buffi

This paper reports the new combination of cell sorting and counting capabilities on a single device. Most state-of-the-art devices combining these technologies use optical techniques requiring complicated experimental setups and labeled samples. The use of ...

Elsevier2011

Epithelial-Mesenchymal Transition-Derived Cells Exhibit Multi-Lineage Differentiation Potential Similar to Mesenchymal Stem Cells

Cathrin Brisken, Ayyakkannu Ayyanan

The epithelial-to-mesenchymal transition (EMT) is an embryonic process that becomes latent in most normal adult tissues. Recently, we have shown that induction of EMT endows breast epithelial cells with stem cell traits. In this report, we have further cha ...

2010

T-cell development occurs in the combined absence of the canonical Wnt signal-transducers beta- and gamma-catenin

Jörg Hülsken, Fabien Kuttler, Ilaria Malanchi

2008

Simultaneous loss of beta- and gamma-catenin does not perturb hematopoiesis or lymphopoiesis

Freddy Radtke, Ute Koch

Hematopietic stem cells (HSCs) maintain life-long hematopoiesis in the bone marrow via their ability to self-renew and to differentiate into all blood lineages. Although a central role for the canonical wnt signaling pathway has been suggested in HSC self- ...

2008

Dynamic simulation of regulatory networks using SQUAD

Giovanni De Micheli, Abhishek Garg

Background The ambition of most molecular biologists is the understanding of the intricate network of molecular interactions that control biological systems. As scientists uncover the components and the connectivity of these networks, it becomes possible t ...

2007