Cathrin Brisken

Expertise Breast cancer; endocrine control mechanisms, precision medicine, patient derived models; estrogen, progesterone,and androgen receptor signaling, Mammary Gland Development, Endocrine Disruptors Mission Cathrin Brisken obtained MD and PhD in Biophysics from the University of Göttingen, Germany, did postdoctoral work at the Whitehead Institute, MIT, Cambridge, USA, and held appointments at the Whitehead Institute, the Cancer Center of the Massachusetts General Hospital, Harvard Medical School and the Swiss Institute for Experimental Cancer Research. She is Associate Professor in Life Sciences at EPFL and Professor at the Institute of Cancer Research London. She was Dean of the EPFL Doctoral School and cofounded the International Cancer Prevention Institute. She has served on many international committees and advisory boards, including AACR Women in Cancer Research Council, International Breast Cancer Study Group Biological Protocol Working Group, Pezcoller Symposia Scientific Committee. Combining mouse genetics with innovative tissue recombination techniques, her laboratory made major contribution to our understanding of reproductive hormone action in vivo. Specific sex hormones, such as estrogens and progesterone impinge directly on a subset of luminal mammary epithelial cells that express the respective hormone receptors and act as sensor cells translating and amplifying systemic signals into local stimuli. Her lab overcame a major hurdle in ER breast cancer research by developing clinically relevant xenograft models. These have opened entirely new perspectives on hormone dependent cancer and provided new insights into tumor dormancy. Doctorants UNIL Ciarloni Laura, Gass Sandra, Beleut Manfred, Schüpbach Sonia, Yalçin Özuysal Özden Enseignement et PhD Doctorant·es actuel·les Lidia Hamed, Karim El-Halabi A dirigé les thèses EPFL de Renuga Devi Rajaram, Duje Buric, Rachel Marcone, Marie Shamseddin, Valentina Scabia, Dalya Ataca, Patrik Aouad, Céline Berthe Constantin, Fabio De Martino, Yueyun Zhang, Andrea Agnoletto, Carlos Henrique Venturi Ronchi, Daria Matvienko Cours Molecular endocrinology: health and environment BIO-450 Nous définirons l'homéostasie, les principes d'action des hormones et leurs mécanismes moléculaires pour illustrer la complexité de la régulation physiologique. Les interactions homme-environnement, les problèmes de santé publique, leurs causes et les stratégies de prévention seront analysés. Practical - Brisken Lab BIO-608 Breast development and cancer.Learn about experimental approaches to study Breast Development and Breast Cancer.