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T-cell development occurs in the combined absence of the canonical Wnt signal-transducers beta- and gamma-catenin

Jörg Hülsken, Fabien Kuttler, Ilaria Malanchi
2008
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Jörg Hülsken, Fabien Kuttler, Ilaria Malanchi
2008
Talks

Source officielle

Publications associées (3)

https://infoscience.epfl.ch/entities/publication/2a9d3e8e-ad8d-4613-83c8-cfbe0161ae52

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Publications associées (3)

Establishment of a microwell-array-based miniaturized thymic organoid model suitable for high-throughput applications

Matthias Lütolf, Tania Hübscher

T cell development depends critically on the thymic stroma—in particular, the diverse array of functionally distinct thymic epithelial cell (TEC) types. However, a robust in vitro thymus model mimicking the native thymus and compatible with medium-/high-th ...

2025

Epithelial-Mesenchymal Transition-Derived Cells Exhibit Multi-Lineage Differentiation Potential Similar to Mesenchymal Stem Cells

Cathrin Brisken, Ayyakkannu Ayyanan

The epithelial-to-mesenchymal transition (EMT) is an embryonic process that becomes latent in most normal adult tissues. Recently, we have shown that induction of EMT endows breast epithelial cells with stem cell traits. In this report, we have further cha ...

2010

Simultaneous loss of beta- and gamma-catenin does not perturb hematopoiesis or lymphopoiesis

Freddy Radtke, Ute Koch

Hematopietic stem cells (HSCs) maintain life-long hematopoiesis in the bone marrow via their ability to self-renew and to differentiate into all blood lineages. Although a central role for the canonical wnt signaling pathway has been suggested in HSC self- ...

2008