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Diego Ghezzi

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Publications associées (49)

Three-dimensional concentric bipolar electrodes for high resolution optic nerve stimulation

Vivien Gaillet, Marta Jole Ildelfonsa Airaghi Leccardi, Diego Ghezzi, Eleonora Borda

ASSOC RESEARCH VISION OPHTHALMOLOGY INC2021

Transient Neurovascular Interface for Minimally Invasive Neural Recording and Stimulation

Philippe Reymond, Diego Ghezzi, Laura Ferlauto, Adele Fanelli, Elodie Geneviève Zollinger

Neural interfaces are used to mitigate the burden of traumatic injuries, neurodegenerative diseases, and mental disorders. However, the transient or permanent placement of an interface in close contact with the neural tissue requires invasive surgery, pote ...

Wiley2021

A machine-learning algorithm correctly classifies cortical evoked potentials from both visual stimulation and electrical stimulation of the optic nerve

Vivien Gaillet, Diego Ghezzi, Eleonora Borda, Elodie Geneviève Zollinger

Objective. Optic nerve's intraneural stimulation is an emerging neuroprosthetic approach to provide artificial vision to totally blind patients. An open question is the possibility to evoke individual non-overlapping phosphenes via selective intraneural op ...

IOP PUBLISHING LTD2021

Photovoltaic retinal prosthesis restores high-resolution responses to single-pixel stimulation in blind retinas

Naïg Aurelia Ludmilla Chenais, Marta Jole Ildelfonsa Airaghi Leccardi, Diego Ghezzi

Retinal prostheses hold the promise of restoring vision in totally blind people. However, a decade of clinical trials highlighted quantitative limitations hampering the possibility of reaching this goal. A key challenge in retinal stimulation is to indepen ...

2021

Organic semiconductors for light-mediated neuromodulation

Diego Ghezzi, Danashi Imani Medagoda

There is growing interest in organic semiconductor devices for light-mediated neuromodulation, such as for retinal stimulation. Here, the key working principles of these devices are discussed, as well as promising applications and outstanding challenges fo ...

SPRINGERNATURE2021

Naturalistic spatiotemporal modulation of epiretinal stimulation increases the response persistence of retinal ganglion cell

Naïg Aurelia Ludmilla Chenais, Marta Jole Ildelfonsa Airaghi Leccardi, Diego Ghezzi

Objective. Retinal stimulation in blind patients evokes the sensation of discrete points of light called phosphenes, which allows them to perform visually guided tasks, such as orientation, navigation, object recognition, object manipulation and reading. H ...

2021

All-polymeric transient neural probe for prolonged in-vivo electrophysiological recordings

Diego Ghezzi, Paola Vagni, Laura Ferlauto, Adele Fanelli, Elodie Geneviève Zollinger

Transient bioelectronics has grown fast, opening possibilities never thought before. In medicine, transient implantable devices are interesting because they could eliminate the risks related to surgical retrieval and reduce the chronic foreign body reactio ...

2021

Questions about the role of P3HT nanoparticles in retinal stimulation

Diego Ghezzi, Daniel Villy Palanker

Nature Portfolio2021

Epiretinal photovoltaic prosthesis with high pixel density

Naïg Aurelia Ludmilla Chenais, Marta Jole Ildelfonsa Airaghi Leccardi, Diego Ghezzi

ASSOC RESEARCH VISION OPHTHALMOLOGY INC2021

Miniaturised Wireless Power Transfer Systems for Neurostimulation: A Review

Sandro Carrara, Diego Ghezzi, Danilo Demarchi, Gian Luca Barbruni

In neurostimulation, wireless power transfer is an efficient technology to overcome several limitations affecting medical devices currently used in clinical practice. Several methods were developed over the years for wireless power transfer. In this review ...

2020

Flow driven robotic navigation of microengineered endovascular probes

Nikolaos Stergiopoulos, Lucio Feo Pancaldi-Giubbini, Pietro Luciano Jakobus Dirix, Diego Ghezzi, Mahmut Selman Sakar, Augusto Martins Lima, Adele Fanelli

Minimally invasive medical procedures, such as endovascular catheterization, have considerably reduced procedure time and associated complications. However, many regions inside the body, such as in the brain vasculature, still remain inaccessible due to th ...

Nature Research2020

Organic electronics for neuroprosthetics

Marta Jole Ildelfonsa Airaghi Leccardi, Diego Ghezzi

2020

Spatially selective activation of the visual cortex via intraneural stimulation of the optic nerve

Vivien Gaillet, Silvestro Micera, Diego Ghezzi, Paola Vagni, Fiorenzo Artoni, Dario Lipucci Di Paola, Ariastity Mega Pratiwi

Retinal prostheses can restore a functional form of vision in patients affected by dystrophies of the outer retinal layer. Beyond clinical utility, prostheses for the stimulation of the optic nerve, the visual thalamus or the visual cortex could also serve ...

2020

All-Printed Electrocorticography Array for In Vivo Neural Recordings

Fabian Michael Lütolf, Diego Ghezzi, Eleonora Borda, Laura Ferlauto, Nenad Marjanovic

Bioelectronic and neuroprosthetic interfaces rely on implanted microelectrode arrays (MEAs) to interact with the human body. Printing techniques, such as inkjet and screen printing, are attractive methods for the manufacturing of MEAs because they allow fl ...

2020

Insertion device for inserting deformable prosthesis into an eye

Charles-Henri Puncho Jérôme Vila, Diego Ghezzi

An insertion device (100; 100') for inserting a retinal prosthesis (200) into the eye of a patient comprises: a handle portion (1; 1') arranged to be grasped by a user of the insertion device (100; 100'), a cannula element (12; 12') arranged to be inserted ...

2020

Photovoltaic organic interface for neuronal stimulation in the near-infrared

Naïg Aurelia Ludmilla Chenais, Marta Jole Ildelfonsa Airaghi Leccardi, Diego Ghezzi, Laura Ferlauto, Elodie Geneviève Zollinger

Organic materials, such as conjugated polymers, are attractive building blocks for bioelectronic interfaces. In particular, organic semiconductors show excellent performance in light-mediated excitation and silencing of neuronal cells and tissues. However, ...

2020

IMPLANTED DEVICES Translation of a photovoltaic retinal prosthesis

Diego Ghezzi

NATURE PUBLISHING GROUP2020

Virtual reality simulation of epiretinal stimulation highlights the relevance of the visual angle in prosthetic vision

Diego Ghezzi, Enrico Migliorini, Jacob Thomas Thorn

Objective. Retinal prostheses hold the potential to restore artificial vision in blind patients suffering from outer retinal dystrophies. The optimal number, density and coverage of the electrodes that a retinal prosthesis should have to provide adequate a ...

2020

Conductive elastomer composites for fully polymeric, flexible bioelectronics

Diego Ghezzi

2019

Capacitive-like photovoltaic epiretinal stimulation enhances and narrows the network-mediated activity of retinal ganglion cells by recruiting the lateral inhibitory network

Naïg Aurelia Ludmilla Chenais, Marta Jole Ildelfonsa Airaghi Leccardi, Diego Ghezzi

Photovoltaic retinal prostheses theoretically offer the possibility of a standalone high-resolution electrical stimulation of the retina. However, achieving focused epiretinal stimulation is particularly challenging, because of axonal activation and electr ...

2019

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