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Diego Ghezzi

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Related publications (48)

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All-polymeric transient neural probe for prolonged in-vivo electrophysiological recordings

Diego Ghezzi, Laura Ferlauto, Paola Vagni, Adele Fanelli, Elodie Geneviève Zollinger

Transient bioelectronics has grown fast, opening possibilities never thought before. In medicine, transient implantable devices are interesting because they could eliminate the risks related to surgical retrieval and reduce the chronic foreign body reactio ...

2021

A 20 Mbps, 433 MHz RF ASK Transmitter to Inductively Power a Distributed Network of Miniaturised Neural Implants

Sandro Carrara, Diego Ghezzi, Gian Luca Barbruni

Simultaneous wireless information and power transfer is an emerging technique in neurotechnology. This work presents an efficient transmitter for both power transfer and downlink data communication to multiple, miniaturised and inductively-powered chips. W ...

IEEE2021

Retinal prostheses: progress toward the next generation implants

Diego Ghezzi

In the last decade, various clinical trials proved the capability of visual prostheses, in particular retinal implants, to restore a useful form of vision. These encouraging results promoted the emerging of several strategies for neuronal stimulation aimin ...

Frontiers Research Foundation2015

An Ultra-Miniaturised CMOS Clock and Data Recovery System for Wireless ASK Transmission

Sandro Carrara, Diego Ghezzi, Gian Luca Barbruni

Over the years, several clock and data recovery architectures have been proposed for wireless Amplitude Shift Keying (ASK) transmitted signals. State-of-the-art architectures mainly rely on synchronous phase-locked loop circuits or selfsampling systems, bo ...

IEEE2023

Spatially selective activation of the visual cortex via intraneural stimulation of the optic nerve

Silvestro Micera, Diego Ghezzi, Fiorenzo Artoni, Paola Vagni, Vivien Gaillet

Retinal prostheses can restore a functional form of vision in patients affected by dystrophies of the outer retinal layer. Beyond clinical utility, prostheses for the stimulation of the optic nerve, the visual thalamus or the visual cortex could also serve ...

2020

Design and validation of a foldable and photovoltaic wide-field epiretinal prosthesis

Diego Ghezzi, Kevin Sivula, Marta Jole Ildelfonsa Airaghi Leccardi, Paola Vagni, Laura Ferlauto, Naïg Aurelia Ludmilla Chenais, Michele Bevilacqua

Retinal prostheses have been developed to fight blindness in people affected by outer retinal layer dystrophies. To date, few hundred patients have received a retinal implant. Inspired by intraocular lenses, we have designed a foldable and photovoltaic wid ...

Nature Research2018

Virtual reality validation of naturalistic modulation strategies to counteract fading in retinal stimulation

Diego Ghezzi, Naïg Aurelia Ludmilla Chenais, Sandrine Brikh

Objective. Temporal resolution is a key challenge in artificial vision. Several prosthetic approaches are limited by the perceptual fading of evoked phosphenes upon repeated stimulation from the same electrode. Therefore, implanted patients are forced to p ...

2022

Development and Characterization of PEDOT:PSS/Alginate Soft Microelectrodes for Application in Neuroprosthetics

Diego Ghezzi, Marta Jole Ildelfonsa Airaghi Leccardi, Paola Vagni, Marc Olivier Heuschkel, Laura Ferlauto, Flavio Maurizio Mor, Estelle Annick Cuttaz

Reducing the mechanical mismatch between the stiffness of a neural implant and the softness of the neural tissue is still an open challenge in neuroprosthetics. The emergence of conductive hydrogels in the last few years has considerably widened the spectr ...

2018

All-Printed Electrocorticography Array for In Vivo Neural Recordings

Diego Ghezzi, Laura Ferlauto, Eleonora Borda, Nenad Marjanovic, Fabian Michael Lütolf

Bioelectronic and neuroprosthetic interfaces rely on implanted microelectrode arrays (MEAs) to interact with the human body. Printing techniques, such as inkjet and screen printing, are attractive methods for the manufacturing of MEAs because they allow fl ...

2020

Engineering Materials for Neurotechnology

Diego Ghezzi

Neurotechnology applies methods and devices to mitigate the burden of neurological and mental disorders. In particular, neural interfaces establish a long-term, seamless, symbiotic integration between implants and neural tissue. Materials play a pivotal ro ...

WILEY-V C H VERLAG GMBH2023

Editorial: Nanomaterials for Communicating With the Brain

Diego Ghezzi

FRONTIERS MEDIA SA2022

Questions about the role of P3HT nanoparticles in retinal stimulation

Daniel Villy Palanker, Diego Ghezzi

Nature Portfolio2021

A Frequency-Switching Inductive Power Transfer System for Wireless, Miniaturised and Large-Scale Neural Interfaces

Sandro Carrara, Diego Ghezzi, Gian Luca Barbruni

Three-coil inductive power transfer is the state-of-the-art solution to power multiple miniaturised neural implants. However, the maximum delivered power is limited by the efficiency of the powering link and safety constrains. Here we propose a frequency-s ...

Ieee-Inst Electrical Electronics Engineers Inc2024

Implantable electrode and method for manufacturing

Diego Ghezzi, Marta Jole Ildelfonsa Airaghi Leccardi

The invention relates to a method for manufacturing an electrode, preferably an implantable electrode array comprising the following steps: Applying (101) a layer of electrically conducting material (4) above a substrate material (1) for forming the electr ...

2018

Insertion device for inserting deformable prosthesis into an eye

Diego Ghezzi, Charles-Henri Puncho Jérôme Vila

An insertion device (100; 100') for inserting a retinal prosthesis (200) into the eye of a patient comprises: a handle portion (1; 1') arranged to be grasped by a user of the insertion device (100; 100'), a cannula element (12; 12') arranged to be inserted ...

2020

Transient electronics: new opportunities for implantable neurotechnology

Diego Ghezzi, Adele Fanelli

Neurotechnology includes artificial devices integrated with the neural tissue to mitigate the burden of neurological and mental disorders. This field has significantly expanded its range of applications thanks to the development of flexible, stretchable an ...

2021

Conformable neural interface based on off-stoichiometry thiol-ene-epoxy thermosets

Diego Ghezzi, Marta Jole Ildelfonsa Airaghi Leccardi, Eleonora Borda, Danashi Imani Medagoda, Elodie Geneviève Zollinger

Off-stoichiometry thiol-ene-epoxy (OSTE+) thermosets show low permeability to gases and little absorption of dissolved molecules, allow direct low-temperature dry bonding without surface treatments, have a low Young's modulus, and can be manufactured via U ...

ELSEVIER SCI LTD2022

An actor-model framework for visual sensory encoding

Demetri Psaltis, Christophe Moser, Diego Ghezzi, Babak Rahmani, Franklin Leong

A fundamental challenge in neuroengineering is determining a proper artificial input to a sensory system that yields the desired perception. In neuroprosthetics, this process is known as artificial sensory encoding, and it holds a crucial role in prostheti ...

Nature Portfolio2024

Virtual reality simulation of epiretinal stimulation highlights the relevance of the visual angle in prosthetic vision

Diego Ghezzi, Jacob Thomas Thorn

Objective. Retinal prostheses hold the potential to restore artificial vision in blind patients suffering from outer retinal dystrophies. The optimal number, density and coverage of the electrodes that a retinal prosthesis should have to provide adequate a ...

2020

Miniaturised Wireless Power Transfer Systems for Neurostimulation: A Review

Sandro Carrara, Diego Ghezzi, Danilo Demarchi, Gian Luca Barbruni

In neurostimulation, wireless power transfer is an efficient technology to overcome several limitations affecting medical devices currently used in clinical practice. Several methods were developed over the years for wireless power transfer. In this review ...

2020