All-Printed Electrocorticography Array for In Vivo Neural Recordings

Bioelectronic and neuroprosthetic interfaces rely on implanted microelectrode arrays (MEAs) to interact with the human body. Printing techniques, such as inkjet and screen printing, are attractive methods for the manufacturing of MEAs because they allow flexible, room-temperature, scalable, and cost-effective fabrication processes. Herein, the fabrication of all-printed electrocorticography arrays made by inkjet printing of platinum and screen printing of polyimide is shown. Next, mechanical and electrochemical characterizations are performed. As a proof of concept, in vivo visually evoked cortical potentials are recorded in rabbits upon flash stimulation. Lastly, it is shown that the all-printed electrocorticography arrays are not cytotoxic. Altogether, the results enable the use of printed MEAs for neurological applications.