Diego Ghezzi

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Publications associées (49)

Gene Editing Preserves Visual Functions in a Mouse Model of Retinal Degeneration

Naïg Aurelia Ludmilla Chenais, Diego Ghezzi, Paola Vagni, Tommaso Marchetti

Inherited retinal dystrophies (IRDs) are a large and heterogeneous group of degenerative diseases caused by mutations in various genes. Given the favorable anatomical and immunological characteristics of the eye, gene therapy holds great potential for thei ...

2019

Upper stimulation threshold for retinal ganglion cell activation

Diego Ghezzi

Objective. The existence of an upper threshold in electrically stimulated retinal ganglion cells (RGCs) is of interest because of its relevance to the development of visual prosthetic devices, which are designed to restore partial sight to blind patients. ...

2018

Multilayer 3D electrodes for neural implants

Marta Jole Ildelfonsa Airaghi Leccardi, Diego Ghezzi, Paola Vagni

Objective. In many applications, multielectrode arrays employed as neural implants require a high density and a high number of electrodes to precisely record and stimulate the activity of the nervous system while preserving the overall size of the array as ...

2018

A microfabricated nerve-on-a-chip platform for rapid assessment of neural conduction in explanted peripheral nerve fibers

Sandra Gribi, Stéphanie Lacour, Sophie du Bois de Dunilac, Diego Ghezzi

Peripheral nerves are anisotropic and heterogeneous neural tissues. Their complex physiology restricts realistic in vitro models, and high resolution and selective probing of axonal activity. Here, we present a nerve-on-a-chip platform that enables rapid e ...

Nature Research2018

Design and validation of a foldable and photovoltaic wide-field epiretinal prosthesis

Kevin Sivula, Naïg Aurelia Ludmilla Chenais, Samuel Charles Antoine Gilliéron, Marta Jole Ildelfonsa Airaghi Leccardi, Diego Ghezzi, Michele Bevilacqua, Paola Vagni, Laura Ferlauto

Retinal prostheses have been developed to fight blindness in people affected by outer retinal layer dystrophies. To date, few hundred patients have received a retinal implant. Inspired by intraocular lenses, we have designed a foldable and photovoltaic wid ...

Nature Research2018

Development and Characterization of PEDOT:PSS/Alginate Soft Microelectrodes for Application in Neuroprosthetics

Marc Olivier Heuschkel, Flavio Maurizio Mor, Estelle Annick Cuttaz, Marta Jole Ildelfonsa Airaghi Leccardi, Diego Ghezzi, Paola Vagni, Laura Ferlauto

Reducing the mechanical mismatch between the stiffness of a neural implant and the softness of the neural tissue is still an open challenge in neuroprosthetics. The emergence of conductive hydrogels in the last few years has considerably widened the spectr ...

2018

Implantable electrode and method for manufacturing

Marta Jole Ildelfonsa Airaghi Leccardi, Diego Ghezzi

The invention relates to a method for manufacturing an electrode, preferably an implantable electrode array comprising the following steps: Applying (101) a layer of electrically conducting material (4) above a substrate material (1) for forming the electr ...

2018

Polymer-based optoelectronic interface and methods for its manufacture

Marta Jole Ildelfonsa Airaghi Leccardi, Diego Ghezzi, Laura Ferlauto

A polymer-based optoelectronic interface comprises an elastomeric substrate (10) and a plurality of discrete photovoltaic pixel elements (20) disposed on top of the substrate. Each pixel element comprises at least one active layer comprising a semiconducti ...

2018

Retinal prostheses: progress toward the next generation implants

Diego Ghezzi

In the last decade, various clinical trials proved the capability of visual prostheses, in particular retinal implants, to restore a useful form of vision. These encouraging results promoted the emerging of several strategies for neuronal stimulation aimin ...

Frontiers Research Foundation2015

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