Publications de Isabelle Barde

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Protein turnover critically influences many biological functions, yet methods have been lacking to assess this parameter in vivo. Here, we demonstrate how chemical labeling of SNAP-tag fusion proteins can be exploited to measure the half-life of resident i ...

The KRAB transcriptional repressor domain, commonly found in zinc finger proteins, acts by inducing the formation of heterochromatin. We previously exploited this property to achieve drug-regulated transgenesis and knock down by combining doxycycline-contr ...

Human cytomegalovirus (HCMV) is a highly prevalent pathogen that induces life-long infections notably through the establishment of latency in hematopoietic stem cells (HSC). Bouts of reactivation are normally controlled by the immune system, but can be fat ...

KAP1 is an essential cofactor of KRAB zinc finger proteins, a family of vertebrate-specific epigenetic repressors of largely unknown functions encoded in the hundreds by the mouse and human genomes. So far, KRAB/KAP1-mediated gene regulation has been studi ...

The present invention relates to an agent or composition comprising at least one of: (i) a micro-RNA targeting a mitophagy-associated gene or a variant thereof, (ii) a vector comprising a nucleic acid encoding said micro-RNA or variant thereof, (iii) an in ...

Isabelle Barde

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Measuring In Vivo Protein Half-Life

KRAB can repress lentivirus proviral transcription independently of integration site

Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch

Regulation of Episomal Gene Expression by KRAB/KAP1-Mediated Histone Modifications

Modulation of mitophagy and use thereof

Control of mitophagie by microRNAs - A key step of erythropoiesis

The questions you should ask yourself for efficient CRISPR/Cas9 genome editing