Recherche

Afficher tous les résultats pour

Accueil

Personne

Jeffrey Alan Hubbell

Cette personne n’est plus à l’EPFL

À propos
Confidentialité
Mentions légales

Graph Chatbot

Publications associées (229)

Dose- and time-dependent angiogenesis by controlled delivery of matrix-bound VEGF

Mikaël Martino, Jeffrey Alan Hubbell, Elena Groppa, Veronica Sacchi

Wiley-Blackwell2012

Precision Intracellular Delivery Based on Optofluidic Polymersome Rupture

Jeffrey Alan Hubbell, Conlin O'Neil, Demetri Psaltis, Andreas Vasdekis

We present an optical approach for intracellular delivery of molecules contained within oxidation-sensitive polymersomes. The photosensitizer ethyl eosin is associated with the polymersome membrane to oxidatively increase the hydrophilicity of the hydropho ...

American Chemical Society2012

Drug development: longer-lived proteins

Jeffrey Alan Hubbell, Stephane Kontos

Protein therapeutics represent a powerful class of clinically approved drugs for the prevention and treatment of various diseases. Once administered, the biological fate of protein therapeutics is governed by the body's various complex biochemical and biop ...

Royal Society of Chemistry2012

Size- and charge-dependent non-specific uptake of PEGylated nanoparticles by macrophages

Jeffrey Alan Hubbell, Susan Thomas

The assessment of macrophage response to nanoparticles is a central component in the evaluation of new nanoparticle designs for future in vivo application. This work investigates which feature, nanoparticle size or charge, is more predictive of non-specifi ...

2012

Sorting Live Stem Cells Based on Sox2 mRNA Expression

Matthias Lütolf, Jeffrey Alan Hubbell, Peter Frey, Seung Tae Lee, Hans Mattias Larsson

While cell sorting usually relies on cell-surface protein markers, molecular beacons (MBs) offer the potential to sort cells based on the presence of any expressed mRNA and in principle could be extremely useful to sort rare cell populations from primary i ...

Public Library of Science2012

Nanoparticle size influences the magnitude and quality of mucosal immune responses after intranasal immunization

Jeffrey Alan Hubbell, Melody Swartz, Eleonora Simeoni, Armando Stano

Background: The development of nanoparticulate antigen-delivery systems is an important emerging area of vaccinology, being sought to amplify immune responses to recombinant antigens that are poorly immunogenic. Nanoparticle size may play an important role ...

Elsevier2012

Dendritic cell activation and T cell priming with adjuvant- and antigen-loaded oxidation-sensitive polymersomes

Jeffrey Alan Hubbell, Melody Swartz, Armando Stano

While current subunit vaccines successfully induce humoral immune responses, a need exists for vaccine strategies to elicit strong cell-mediated immunity to address diseases such as cancer and chronic viral infection. Polymersomes are stable vesicles compo ...

2012

Longterm cell-demanded release of TG-VEGF for the development of mature vascular networks in vivo

Jeffrey Alan Hubbell, Daniel Eberli, Kristen Lorentz, Martin Ehrbar

Wiley-Blackwell2012

Reduction-Sensitive Tioguanine Prodrug Micelles

Jeffrey Alan Hubbell, Urara Hasegawa

Colloidal drug and prodrug conjugates have unique targeting characteristics for tumor vasculature from the blood and for the lymphatics draining a tissue injection site. Tioguanine and tioguanine-generating prodrugs have been investigated as anticancer and ...

Amer Chemical Soc2012

A collagen-poly(lactic acid-co-epsilon-caprolactone) hybrid scaffold for bladder tissue regeneration

Florian Maria Wurm, Lionel Ambroise Micol, Jeffrey Alan Hubbell, Peter Frey

Scaffold materials should favor cell attachment and proliferation, and provide designable 3D structures with appropriate mechanical strength. Collagen matrices have proven to be beneficial scaffolds for tissue regeneration. However, apart from small intest ...

2011

SPARC-derived protease substrates to enhance the plasmin sensitivity of molecularly engineered PEG hydrogels

Jeffrey Alan Hubbell

Bioactive hydrogels formed from the Michael-type addition reactions of end-functionalized poly (ethylene glycol) macromers with thiol-containing protease-sensitive peptide crosslinkers have previously been described as matrices for cell-induced enzymatic r ...

2011

Extracellular matrix in angiogenesis: dynamic structures with translational potential

Jeffrey Alan Hubbell

The vascular network is an integral component of most organs. Beyond assuring an adequate supply of oxygen and nutrients for normal tissue function, vascular structures provide also a critical interface in the balance of tissue homoeostasis and immune func ...

2011

Human embryonic stem cell-derived microvascular grafts for cardiac tissue preservation after myocardial infarction

Jeffrey Alan Hubbell

We present use of a synthetic, injectable matrix metalloproteinase (MMP)- responsive, bioactive hydrogel as an in situ forming scaffold to deliver thymosin beta 4 (T beta 4), a pro-angiogenic and pro-survival factor, along with vascular cells derived from ...

2011

Enzymatic- and temperature-sensitive controlled release of ultrasmall superparamagnetic iron oxides (USPIOs)

Jeffrey Alan Hubbell, Conlin O'Neil

Background: Drug and contrast agent delivery systems that achieve controlled release in the presence of enzymatic activity are becoming increasingly important, as enzymatic activity is a hallmark of a wide array of diseases, including cancer and atheroscle ...

2011

PEG-b-PPS-b-PEI micelles and PEG-b-PPS/PEG-b-PPS-b-PEI mixed micelles as non-viral vectors for plasmid DNA: Tumor immunotoxicity in B16F10 melanoma

Jeffrey Alan Hubbell, Melody Swartz, Eleonora Simeoni, Susan Thomas

Cationic micelles formed from poly(ethylene glycol)-bl-poly(propylene sulfide)-bl-poly(ethylene imine) (PEG-b-PPS-b-PEI) and from mixtures of poly(ethylene glycol)-bl-poly(propylene sulfide) (PEG-b-PPS) with PEG-b-PPS-b-PEI were explored as non-viral vecto ...

2011

Nanoparticle conjugation and pulmonary delivery enhance the protective efficacy of Ag85B and CpG against tuberculosis

Jeffrey Alan Hubbell, Melody Swartz, Cyntia De Piano, Alexandre de Titta, Marie Ballester, Miriella Carmela Pasquier, Eleonora Simeoni, John McKinney, Neeraj Dhar

Vaccines that drive robust T-cell immunity against Mycobacterium tuberculosis (Mtb) are needed both for prophylactic and therapeutic purposes. We have recently developed a synthetic vaccine delivery platform with Pluronic-stabilized polypropylene sulfide n ...

2011

PPS nanoparticles as versatile delivery system to induce systemic and broad mucosal immunity after intranasal administration

Mikaël Martino, Jeffrey Alan Hubbell, Melody Swartz, Eleonora Simeoni, Armando Stano

Degradable polymer nanoparticles (NPs, 50nm) based on polypropylene sulfide (PPS) were conjugated to thiolated antigen and adjuvant proteins by reversible disulfide bonds and evaluated in mucosal vaccination. Ovalbumin was used as a model antigen, and anti ...

Elsevier2011

High-density collagen gel tubes as a matrix for primary human bladder smooth muscle cells

Lionel Ambroise Micol, Jeffrey Alan Hubbell, Peter Frey

Tissue-engineered grafts for the urinary tract are being investigated for the potential treatment of several urologic diseases. These grafts, predominantly tubular-shaped, usually require in vitro culture prior to implantation to allow cell engraftment on ...

Elsevier2011

Nanoparticles for immunotherapy

Jeffrey Alan Hubbell, Melody Swartz, Sai Reddy

Nanoparticles that activate complement in the absence of biological molecules are described. The nanoparticles are shown to specifically target antigen presenting cells in specifically in lymph nodes, without the use of a biological molecule for targeting. ...

2011

Tg-aprotinin fusion proteins and matrices thereof

Jeffrey Alan Hubbell, Peter Frey, Kristen Lorentz

Fusion proteins containing a first domain and a second domain, where the first domain contains a crosslinkable substrate domain and the second domain contains a fibrinolysis inhibitor, are provided. In a preferred embodiment, the fibrinolysis inhibitor is ...

2011

Page 7 sur 12